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UniProtKB/Swiss-Prot entry O95777


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LSM8_HUMAN
Primary accession number O95777
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    November 4, 2008 (Entry version 76)
Name and origin of the protein
Protein name U6 snRNA-associated Sm-like protein LSm8
Synonyms None
Gene name
Name: LSM8
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE, AND PARTIAL PROTEIN SEQUENCE.
DOI=10.1093/emboj/18.20.5789; PubMed=10523320 [NCBI, ExPASy, EBI, Israel, Japan]
Achsel T., Brahms H., Kastner B., Bachi A., Wilm M., Luehrmann R.;
"A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro.";
EMBO J. 18:5789-5802(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature01782; PubMed=12853948 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.;
"The DNA sequence of human chromosome 7.";
Nature 424:157-164(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, and Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PROTEIN SEQUENCE OF 2-11; 29-44 AND 88-96, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT THR-2, AND MASS SPECTROMETRY.
TISSUE=B-cell lymphoma;
Bienvenut W.V.;
Submitted (JUL-2005) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF182294; AAD56232.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC006389; AAD15542.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC002742; AAH02742.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC022440; AAH22440.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_057284.1; -.
UniGene Hs.657737
3D structure databases
HSSP O26745; 1JBM. [HSSP ENTRY / PDB]
ModBase O95777.
Protein-protein interaction databases
IntAct O95777; -.
Organism-specific databases
H-InvDB HIX0007025; -.
HGNC HGNC:20471; LSM8.
GenAtlas LSM8.
MIM 607288; gene. [NCBI / EBI]
PharmGKB PA134930584; -.
GeneCards O95777.
Gene expression databases
ArrayExpress O95777; -.
CleanEx HS_LSM8; -.
GermOnline ENSG00000128534; Homo sapiens.
Ontologies
GO
GO:0005634; Cellular component: nucleus (non-traceable author statement from UniProtKB).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0017070; Molecular function: U6 snRNA binding (non-traceable author statement from UniProtKB).
GO:0000398; Biological process: nuclear mRNA splicing, via spliceosome (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR006649; Euk_arc_LSM_core.
IPR001163; LSM_snRNP_core.
Graphical view of domain structure.
Pfam PF01423; LSM; 1.
Pfam graphical view of domain structure.
ProDom PD020287; snRNP; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00651; Sm; 1.
SMART graphical view of domain structure.
BLOCKS O95777.
ProtoNet O95777.
Proteomic databases
PeptideAtlas O95777; -.
Genome annotation databases
Ensembl ENSG00000128534; Homo sapiens. [Contig view]
GeneID 51691; -.
KEGG hsa:51691; -.
Phylogenomic databases
HOGENOM O95777; -.
HOVERGEN O95777; -.
Other
NextBio 55698; -.
SOURCE LSM8; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Ribonucleoprotein; RNA-binding.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
INIT_MET   1    1        Removed. 
CHAIN   2   96  95     U6 snRNA-associated Sm-like protein LSm8. PRO_0000125582
MOD_RES   2    2        N-acetylthreonine. 
Sequence information
Length: 96 AA [This is the length of the unprocessed precursor] Molecular weight: 10403 Da [This is the MW of the unprocessed precursor] CRC64: 15D26E6B75AA2EE1 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTSALENYIN RTVAVITSDG RMIVGTLKGF DQTINLILDE SHERVFSSSQ GVEQVVLGLY 

        70         80         90 
IVRGDNVAVI GEIDEETDSA LDLGNIRAEP LNSVAH 

O95777 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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