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UniProtKB/Swiss-Prot entry O95757


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HS74L_HUMAN
Primary accession number O95757
Secondary accession numbers Q4W5M5 Q8IWA2
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on May 23, 2003 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 68)
Name and origin of the protein
Protein name Heat shock 70 kDa protein 4L
Synonyms Osmotic stress protein 94
Heat shock 70-related protein APG-1
Gene name
Name: HSPA4L
Synonyms: APG1, OSP94
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Testis;
DOI=10.1016/S0378-1119(99)00325-X; PubMed=10524232 [NCBI, ExPASy, EBI, Israel, Japan]
Nonoguchi K., Itoh K., Xue J.H., Tokuchi H., Nishiyama H., Kaneko Y., Tatsumi K., Okuno H., Tomiwa K., Fujita J.;
"Cloning of human cDNAs for Apg-1 and Apg-2, members of the Hsp110 family, and chromosomal assignment of their genes.";
Gene 237:21-28(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT LEU-211.
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-211.
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-761, AND MASS SPECTROMETRY.
DOI=10.1126/science.1140321; PubMed=17525332 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.";
Science 316:1160-1166(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB023421; BAA75063.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC093591; AAY40975.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC040560; AAH40560.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_055093.2; -.
UniGene Hs.135554
3D structure databases
HSSP P08107; 1HJO. [HSSP ENTRY / PDB]
ModBase O95757.
Protein-protein interaction databases
IntAct O95757; -.
PTM databases
PhosphoSite O95757; -.
2D gel databases
REPRODUCTION-2DPAGE IPI00295485; -.
Organism-specific databases
HGNC HGNC:17041; HSPA4L.
GenAtlas HSPA4L.
PharmGKB PA134905749; -.
GeneCards O95757.
Gene expression databases
ArrayExpress O95757; -.
CleanEx HS_HSPA4L; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from sequence or structural similarity from UniProtKB).
GO:0005634; Cellular component: nucleus (inferred from sequence or structural similarity from UniProtKB).
GO:0005524; Molecular function: ATP binding (inferred from sequence or structural similarity from UniProtKB).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0006457; Biological process: protein folding (inferred from sequence or structural similarity from UniProtKB).
GO:0006986; Biological process: response to unfolded protein (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001023; Hsp70.
IPR013126; Hsp_70.
Graphical view of domain structure.
PANTHER PTHR19375; Hsp70; 1.
Pfam PF00012; HSP70; 1.
Pfam graphical view of domain structure.
PRINTS PR00301; HEATSHOCK70.
ProDom PD000089; Hsp70; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00297; HSP70_1; FALSE_NEG.
PS00329; HSP70_2; 1.
PS01036; HSP70_3; 1.
BLOCKS O95757.
Genome annotation databases
Ensembl ENSG00000164070; Homo sapiens. [Contig view]
GeneID 22824; -.
KEGG hsa:22824; -.
Phylogenomic databases
HOGENOM O95757; -.
HOVERGEN O95757; -.
Other
LinkHub O95757; -.
ProtoNet O95757.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Stress response.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   839  839     Heat shock 70 kDa protein 4L. PRO_0000078280
MOD_RES   74    74        Phosphoserine (By similarity). 
MOD_RES   761   761        Phosphothreonine. 
VARIANT   211   211  1     S -> L (in dbSNP:rs1380154 [NCBI]). VAR_025405 
VARIANT   216   216  1     N -> T (in dbSNP:rs12507229 [NCBI]). VAR_031214 
CONFLICT   806   806        H -> R (in Ref. 1; BAA75063). 
Sequence information
Length: 839 AA [This is the length of the unprocessed precursor] Molecular weight: 94486 Da [This is the MW of the unprocessed precursor] CRC64: AB9936A3F32AAE8E [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSVVGIDLGF LNCYIAVARS GGIETIANEY SDRCTPACIS LGSRTRAIGN AAKSQIVTNV 

        70         80         90        100        110        120 
RNTIHGFKKL HGRSFDDPIV QTERIRLPYE LQKMPNGSAG VKVRYLEEER PFAIEQVTGM 

       130        140        150        160        170        180 
LLAKLKETSE NALKKPVADC VISIPSFFTD AERRSVMAAA QVAGLNCLRL MNETTAVALA 

       190        200        210        220        230        240 
YGIYKQDLPP LDEKPRNVVF IDMGHSAYQV SVCAFNKGKL KVLATTFDPY LGGRNFDEAL 

       250        260        270        280        290        300 
VDYFCDEFKT KYKINVKENS RALLRLYQEC EKLKKLMSAN ASDLPLNIEC FMNDLDVSSK 

       310        320        330        340        350        360 
MNRAQFEQLC ASLLARVEPP LKAVMEQANL QREDISSIEI VGGATRIPAV KEQITKFFLK 

       370        380        390        400        410        420 
DISTTLNADE AVARGCALQC AILSPAFKVR EFSITDLVPY SITLRWKTSF EDGSGECEVF 

       430        440        450        460        470        480 
CKNHPAPFSK VITFHKKEPF ELEAFYTNLH EVPYPDARIG SFTIQNVFPQ SDGDSSKVKV 

       490        500        510        520        530        540 
KVRVNIHGIF SVASASVIEK QNLEGDHSDA PMETETSFKN ENKDNMDKMQ VDQEEGHQKC 

       550        560        570        580        590        600 
HAEHTPEEEI DHTGAKTKSA VSDKQDRLNQ TLKKGKVKSI DLPIQSSLCR QLGQDLLNSY 

       610        620        630        640        650        660 
IENEGKMIMQ DKLEKERNDA KNAVEEYVYD FRDRLGTVYE KFITPEDLSK LSAVLEDTEN 

       670        680        690        700        710        720 
WLYEDGEDQP KQVYVDKLQE LKKYGQPIQM KYMEHEERPK ALNDLGKKIQ LVMKVIEAYR 

       730        740        750        760        770        780 
NKDERYDHLD PTEMEKVEKC ISDAMSWLNS KMNAQNKLSL TQDPVVKVSE IVAKSKELDN 

       790        800        810        820        830 
FCNPIIYKPK PKAEVPEDKP KANSEHNGPM DGQSGTETKS DSTKDSSQHT KSSGEMEVD 

O95757 in FASTA format

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