[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Brain; DOI=10.1016/S0014-5793(98)00497-9; PubMed=9645480 [NCBI, ExPASy, EBI, Israel, Japan] Nakayama T., Yaoi T., Yasui M., Kuwajima G.; "N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression."; FEBS Lett. 428:80-84(1998).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain; Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.; Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties. May have a role in synaptic plasticity (By similarity).
SIMILARITY: Belongs to the copine family.
SIMILARITY: Contains 2 C2 domains.
SIMILARITY: Contains 1 VWFA domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB009288; BAA75899.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AK222675; BAD96395.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC018046; AAH18046.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_006023.1; -.

UniGene

Hs.6132

3D structure databases

HSSP

P10688; 1DJH. [HSSP ENTRY / PDB]

ModBase

O95741.

Protein-protein interaction databases

IntAct

O95741; -.

PTM databases

PhosphoSite

O95741; -.

Organism-specific databases

HGNC:2319; CPNE6.

605688; gene. [NCBI / EBI]

PharmGKB

PA26836; -.

GeneCards

O95741.

Gene expression databases

ArrayExpress

O95741; -.

CleanEx

HS_CPNE6; -.

GermOnline

ENSG00000100884; Homo sapiens.

Ontologies

GO:0005509;	Molecular function: calcium ion binding (traceable author statement from ProtInc).
GO:0005215;	Molecular function: transporter activity (traceable author statement from ProtInc).
GO:0006629;	Biological process: lipid metabolic process (traceable author statement from ProtInc).
GO:0007399;	Biological process: nervous system development (traceable author statement from ProtInc).
GO:0007268;	Biological process: synaptic transmission (traceable author statement from ProtInc).
GO:0016192;	Biological process: vesicle-mediated transport (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR000008; C2_Ca-dep.
IPR010734; Copine.
IPR002035; VWF_A.
Graphical view of domain structure.

Pfam

PF00168; C2; 2.
PF07002; Copine; 1.
Pfam graphical view of domain structure.

PRINTS

PR00360; C2DOMAIN.

SMART

SM00239; C2; 2.
SM00327; VWA; 1.
SMART graphical view of domain structure.

PROSITE

PS50004; C2; 1.
PS50234; VWFA; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

O95741; -.

Genome annotation databases

Ensembl

ENSG00000100884; Homo sapiens. [Contig view]

GeneID

9362; -.

KEGG

hsa:9362; -.

Phylogenomic databases

HOGENOM

O95741; -.

HOVERGEN

O95741; -.

Other

NextBio

35059; -.

SOURCE

CPNE6; Homo sapiens.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Phosphoprotein; Repeat.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 557`	`557`	`Copine-6.`	`PRO_0000144845`
`DOMAIN`	`24 111`	`88`	`C2 1.`
`DOMAIN`	`138 243`	`106`	`C2 2.`
`DOMAIN`	`306 526`	`221`	`VWFA.`
`MOD_RES`	`65 65`		`Phosphoserine (By similarity).`
`CONFLICT`	`13 13`		`P -> Q (in Ref. 3; AAH18046).`
`CONFLICT`	`87 87`		`L -> V (in Ref. 3; AAH18046).`
`CONFLICT`	`331 331`		`P -> H (in Ref. 2; BAD96395).`

Sequence information

Length: 557 AA [This is the length of the unprocessed precursor]

Molecular weight: 61991 Da [This is the MW of the unprocessed precursor]

CRC64: CA1ECA3560926FC2 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSDPEMGWVP EPPTMTLGAS RVELRVSCHG LLDRDTLTKP HPCVLLKLYS DEQWVEVERT 

        70         80         90        100        110        120 
EVLRSCSSPV FSRVLALEYF FEEKQPLQFH VFDAEDGATS PRNDTFLGST ECTLGQIVSQ 

       130        140        150        160        170        180 
TKVTKPLLLK NGKTAGKSTI TIVAEEVSGT NDYVQLTFRA YKLDNKDLFS KSDPFMEIYK 

       190        200        210        220        230        240 
TNEDQSDQLV WRTEVVKNNL NPSWEPFRLS LHSLCSCDVH RPLKFLVYDY DSSGKHDFIG 

       250        260        270        280        290        300 
EFTSTFQEMQ EGTANPGQEM QWDCINPKYR DKKKNYKSSG TVVLAQCTVE KVHTFLDYIM 

       310        320        330        340        350        360 
GGCQISFTVA IDFTASNGDP RSSQSLHCLS PRQPNHYLQA LRAVGGICQD YDSDKRFPAF 

       370        380        390        400        410        420 
GFGARIPPNF EVSHDFAINF DPENPECEEI SGVIASYRRC LPQIQLYGPT NVAPIINRVA 

       430        440        450        460        470        480 
EPAQREQSTG QATKYSVLLV LTDGVVSDMA ETRTAIVRAS RLPMSIIIVG VGNADFSDMR 

       490        500        510        520        530        540 
LLDGDDGPLR CPRGVPAARD IVQFVPFRDF KDAAPSALAK CVLAEVPRQV VEYYASQGIS 

       550 
PGAPRPCTLA TTPSPSP

O95741 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools