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UniProtKB/Swiss-Prot entry O95622


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADCY5_HUMAN
Primary accession number O95622
Secondary accession numbers Q7RTV7 Q8NFM3
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on November 28, 2006 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 71)
Name and origin of the protein
Protein name Adenylate cyclase type 5
Synonyms EC 4.6.1.1
Adenylate cyclase type V
ATP pyrophosphate-lyase 5
Adenylyl cyclase 5
Gene name
Name: ADCY5
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04728; PubMed=16641997 [NCBI, ExPASy, EBI, Israel, Japan]
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
"The DNA sequence, annotation and analysis of human chromosome 3.";
Nature 440:1194-1198(2006).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 368-1261.
TISSUE=Heart;
DOI=10.1081/RRS-120014589; PubMed=12503609 [NCBI, ExPASy, EBI, Israel, Japan]
Ludwig M.G., Seuwen K.;
"Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.";
J. Recept. Signal Transduct. Res. 22:79-110(2002).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 560-664.
TISSUE=Heart muscle;
DOI=10.1016/S0009-8981(99)00067-4; PubMed=10481931 [NCBI, ExPASy, EBI, Israel, Japan]
Raimundo S., Giray J., Volff J.-N., Schwab M., Altenbuchner J., Ratge D., Wisser H.;
"Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues.";
Clin. Chim. Acta 285:155-161(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AC025571; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AF497517; AAM94374.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U65473; AAD00121.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BK000371; DAA00057.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_899200.1; -.
UniGene Hs.593293
3D structure databases
HSSP P30803; 1AZS. [HSSP ENTRY / PDB]
SMR O95622; 454-643.
ModBase O95622.
PTM databases
PhosphoSite O95622; -.
Organism-specific databases
H-InvDB HIX0003612; -.
HGNC HGNC:236; ADCY5.
GenAtlas ADCY5.
HPA HPA017730; -.
MIM 600293; gene. [NCBI / EBI]
PharmGKB PA24563; -.
GeneCards O95622.
Gene expression databases
ArrayExpress O95622; -.
CleanEx HS_ADCY5; -.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0004016; Molecular function: adenylate cyclase activity (inferred from electronic annotation from InterPro).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006171; Biological process: cAMP biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0007242; Biological process: intracellular signaling cascade (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001054; A/G_cyclase.
IPR009398; Aden_cycl_like.
Graphical view of domain structure.
Gene3D G3DSA:3.30.70.1230; A/G_cyclase; 2.
Pfam PF06327; DUF1053; 1.
PF00211; Guanylate_cyc; 2.
Pfam graphical view of domain structure.
SMART SM00044; CYCc; 2.
SMART graphical view of domain structure.
PROSITE PS00452; GUANYLATE_CYCLASE_1; 2.
PS50125; GUANYLATE_CYCLASE_2; 2.
PROSITE graphical view of domain structure (profiles).
ProtoNet O95622.
Genome annotation databases
Ensembl ENSG00000173175; Homo sapiens. [Contig view]
GeneID 111; -.
KEGG hsa:111; -.
Phylogenomic databases
HOGENOM O95622; -.
HOVERGEN O95622; -.
Other
NextBio 427; -.
SOURCE ADCY5; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
cAMP biosynthesis; Glycoprotein; Lyase; Magnesium; Membrane; Metal-binding; Phosphoprotein; Repeat; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1261  1261     Adenylate cyclase type 5. PRO_0000195694
TOPO_DOM   1    195  195     Cytoplasmic (Potential). 
TRANSMEM   196    216  21     Potential. 
TRANSMEM   242    262  21     Potential. 
TRANSMEM   268    288  21     Potential. 
TRANSMEM   299    319  21     Potential. 
TRANSMEM   325    345  21     Potential. 
TRANSMEM   349    369  21     Potential. 
TRANSMEM   374    394  21     Potential. 
TOPO_DOM   395    769  375     Cytoplasmic (Potential). 
TRANSMEM   770    790  21     Potential. 
TRANSMEM   792    812  21     Potential. 
TRANSMEM   836    856  21     Potential. 
TOPO_DOM   857    909  53     Extracellular (Potential). 
TRANSMEM   910    930  21     Potential. 
TRANSMEM   935    955  21     Potential. 
TRANSMEM   984   1004  21     Potential. 
TOPO_DOM   1005   1261  257     Cytoplasmic (Potential). 
DOMAIN   469    596  128     Guanylate cyclase 1. 
DOMAIN   1071   1210  140     Guanylate cyclase 2. 
METAL   474    474        Magnesium 1 (By similarity). 
METAL   474    474        Magnesium 2 (By similarity). 
METAL   475    475        Magnesium 2; via carbonyl oxygen (By similarity). 
METAL   518    518        Magnesium 1 (By similarity). 
METAL   518    518        Magnesium 2 (By similarity). 
MOD_RES   8      8        Phosphoserine (By similarity). 
CARBOHYD   870    870        N-linked (GlcNAc...) (Potential). 
CARBOHYD   887    887        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 1261 AA [This is the length of the unprocessed precursor] Molecular weight: 138908 Da [This is the MW of the unprocessed precursor] CRC64: C50492A0B053694F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSGSKSVSPP GYAAQKTAAP APRGGPEHRS AWGEADSRAN GYPHAPGGSA RGSTKKPGGA 

        70         80         90        100        110        120 
VTPQQQQRLA SRWRSDDDDD PPLSGDDPLA GGFGFSFRSK SAWQERGGDD CGRGSRRQRR 

       130        140        150        160        170        180 
GAASGGSTRA PPAGGGGGSA AAAASAGGTE VRPRSVEVGL EERRGKGRAA DELEAGAVEG 

       190        200        210        220        230        240 
GEGSGDGGSS ADSGSGAGPG AVLSLGACCL ALLQIFRSKK FPSDKLERLY QRYFFRLNQS 

       250        260        270        280        290        300 
SLTMLMAVLV LVCLVMLAFH AARPPLQLPY LAVLAAAVGV ILIMAVLCNR AAFHQDHMGL 

       310        320        330        340        350        360 
ACYALIAVVL AVQVVGLLLP QPRSASEGIW WTVFFIYTIY TLLPVRMRAA VLSGVLLSAL 

       370        380        390        400        410        420 
HLAIALRTNA QDQFLLKQLV SNVLIFSCTN IVGVCTHYPA EVSQRQAFQE TRECIQARLH 

       430        440        450        460        470        480 
SQRENQQQER LLLSVLPRHV AMEMKADINA KQEDMMFHKI YIQKHDNVSI LFADIEGFTS 

       490        500        510        520        530        540 
LASQCTAQEL VMTLNELFAR FDKLAAENHC LRIKILGDCY YCVSGLPEAR ADHAHCCVEM 

       550        560        570        580        590        600 
GMDMIEAISL VREVTGVNVN MRVGIHSGRV HCGVLGLRKW QFDVWSNDVT LANHMEAGGK 

       610        620        630        640        650        660 
AGRIHITKAT LNYLNGDYEV EPGCGGERNA YLKEHSIETF LILRCTQKRK EEKAMIAKMN 

       670        680        690        700        710        720 
RQRTNSIGHN PPHWGAERPF YNHLGGNQVS KEMKRMGFED PKDKNAQESA NPEDEVDEFL 

       730        740        750        760        770        780 
GRAIDARSID RLRSEHVRKF LLTFREPDLE KKYSKQVDDR FGAYVACASL VFLFICFVQI 

       790        800        810        820        830        840 
TIVPHSIFML SFYLTCSLLL TLVVFVSVIY SCVKLFPSPL QTLSRKIVRS KMNSTLVGVF 

       850        860        870        880        890        900 
TITLVFLAAF VNMFTCNSRD LLGCLAQEHN ISASQVNACH VAESAVNYSL GDEQGFCGSP 

       910        920        930        940        950        960 
WPNCNFPEYF TYSVLLSLLA CSVFLQISCI GKLVLMLAIE LIYVLIVEVP GVTLFDNADL 

       970        980        990       1000       1010       1020 
LVTANAIDFF NNGTSQCPEH ATKVALKVVT PIIISVFVLA LYLHAQQVES TARLDFLWKL 

      1030       1040       1050       1060       1070       1080 
QATEEKEEME ELQAYNRRLL HNILPKDVAA HFLARERRND ELYYQSCECV AVMFASIANF 

      1090       1100       1110       1120       1130       1140 
SEFYVELEAN NEGVECLRLL NEIIADFDEI ISEDRFRQLE KIKTIGSTYM AASGLNDSTY 

      1150       1160       1170       1180       1190       1200 
DKVGKTHIKA LADFAMKLMD QMKYINEHSF NNFQMKIGLN IGPVVAGVIG ARKPQYDIWG 

      1210       1220       1230       1240       1250       1260 
NTVNVASRMD STGVPDRIQV TTDMYQVLAA NTYQLECRGV VKVKGKGEMM TYFLNGGPPL 


S 

O95622 in FASTA format

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