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UniProtKB/Swiss-Prot entry O95490


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LPHN2_HUMAN
Primary accession number O95490
Secondary accession numbers O94882 Q5VX76 Q9UKY5 Q9UKY6
Integrated into Swiss-Prot on April 26, 2004
Sequence was last modified on April 26, 2004 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 70)
Name and origin of the protein
Protein name Latrophilin-2 [Precursor]
Synonyms Calcium-independent alpha-latrotoxin receptor 2
Latrophilin homolog 1
Lectomedin-1
Gene name
Name: LPHN2
Synonyms: KIAA0786, LEC1, LPHH1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
DOI=10.1038/sj.onc.1202487; PubMed=10030676 [NCBI, ExPASy, EBI, Israel, Japan]
White G.R.M., Varley J.M., Heighway J.;
"Isolation and characterisation of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer.";
Oncogene 17:3513-3519(1998).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/S0167-4781(00)00020-8; PubMed=10760572 [NCBI, ExPASy, EBI, Israel, Japan]
White G.R.M., Varley J.M., Heighway J.;
"Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines.";
Biochim. Biophys. Acta 1491:75-92(2000).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4).
Hayflick J.S.;
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 439-1459 (ISOFORM 1).
TISSUE=Brain;
DOI=10.1093/dnares/5.5.277; PubMed=9872452 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.";
DNA Res. 5:277-286(1998).
[6]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
[7]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-629, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1021/pr8008012; PubMed=19159218 [NCBI, ExPASy, EBI, Israel, Japan]
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.";
J. Proteome Res. 8:651-661(2009).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ131581; CAA10458.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ244492; CAB60229.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ244493; CAB60229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ244494; CAB60229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ244496; CAB60229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ244497; CAB60229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ244498; CAB60229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ244499; CAB60229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ244501; CAB60229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ244502; CAB60229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ244503; CAB60229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ244504; CAB60229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ244505; CAB60229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ244506; CAB60229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ244507; CAB60229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ244510; CAB60229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ244511; CAB60229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ244512; CAB60229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ244516; CAB60229.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF104938; AAD54676.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF104266; AAD54675.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF104939; AAD54677.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL157903; CAI22401.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC113949; CAI22401.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL359705; CAI22401.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL359705; CAH71347.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC113949; CAH71347.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL157903; CAH71347.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB018329; BAA34506.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00017562; -.
IPI00164345; -.
IPI00410232; -.
IPI00410234; -.
RefSeq NP_036434.1; -.
UniGene Hs.24212
3D structure databases
ModBase O95490.
Protein family/group databases
GPCRDB O95490; LPHN2_HUMAN.
PTM databases
PhosphoSite O95490; -.
Organism-specific databases
GeneCards GC01P081588; -.
HGNC HGNC:18582; LPHN2.
GenAtlas LPHN2.
HPA HPA013573; -.
MIM 607018; gene. [NCBI / EBI]
PharmGKB PA38589; -.
HUGE KIAA0786.
Gene expression databases
ArrayExpress O95490; -.
Bgee O95490; -.
CleanEx HS_LPHN2; -.
GermOnline ENSG00000117114; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (non-traceable author statement from UniProtKB).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004930; Molecular function: G-protein coupled receptor activity (traceable author statement from GDB).
GO:0016524; Molecular function: latrotoxin receptor activity (non-traceable author statement from UniProtKB).
GO:0005529; Molecular function: sugar binding (inferred from electronic annotation from UniProtKB-KW).
GO:0007218; Biological process: neuropeptide signaling pathway (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR017981; GPCR_2-like.
IPR001879; GPCR_2_extracellular.
IPR003924; GPCR_2_latrophilin.
IPR003334; GPCR_2_latrophilin_rcpt_C.
IPR000832; GPCR_2_secretin-like.
IPR017983; GPCR_2_secretin-like_CS.
IPR000922; Lectin_gal_bd.
IPR003112; Olfac-like.
IPR000203; PKD_cys_rich.
Graphical view of domain structure.
Pfam PF00002; 7tm_2; 1.
PF02140; Gal_Lectin; 1.
PF01825; GPS; 1.
PF02793; HRM; 1.
PF02354; Latrophilin; 1.
PF02191; OLF; 1.
Pfam graphical view of domain structure.
PRINTS PR00249; GPCRSECRETIN.
PR01444; LATROPHILIN.
ProDom PD005612; Gal_lectin; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00303; GPS; 1.
SM00008; HormR; 1.
SM00284; OLF; 1.
SMART graphical view of domain structure.
PROSITE PS00649; G_PROTEIN_RECEP_F2_1; FALSE_NEG.
PS00650; G_PROTEIN_RECEP_F2_2; 1.
PS50227; G_PROTEIN_RECEP_F2_3; 1.
PS50261; G_PROTEIN_RECEP_F2_4; 1.
PS50221; GPS; 1.
PS51132; OLF; 1.
PS50228; SUEL_LECTIN; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE O95490; -.
Genome annotation databases
Ensembl ENSG00000117114; Homo sapiens. [Contig view]
GeneID 23266; -.
KEGG hsa:23266; -.
Phylogenomic databases
HOVERGEN O95490; -.
Other
NextBio 45018; -.
SOURCE LPHN2; Homo sapiens.
GPCRDB-Snakes O95490.
ProtoNet O95490.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; Lectin; Membrane; Phosphoprotein; Receptor; Signal; Transducer; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
SIGNAL   1     25  25     Potential. 
CHAIN   26   1459  1434     Latrophilin-2. PRO_0000012910
TOPO_DOM   39    851  813     Extracellular (Potential). 
TRANSMEM   852    872  21     1 (Potential). 
TOPO_DOM   873    880  8     Cytoplasmic (Potential). 
TRANSMEM   881    901  21     2 (Potential). 
TOPO_DOM   902    907  6     Extracellular (Potential). 
TRANSMEM   908    928  21     3 (Potential). 
TOPO_DOM   929    952  24     Cytoplasmic (Potential). 
TRANSMEM   953    973  21     4 (Potential). 
TOPO_DOM   974    990  17     Extracellular (Potential). 
TRANSMEM   991   1011  21     5 (Potential). 
TOPO_DOM   1012   1037  26     Cytoplasmic (Potential). 
TRANSMEM   1038   1058  21     6 (Potential). 
TOPO_DOM   1059   1062  4     Extracellular (Potential). 
TRANSMEM   1063   1083  21     7 (Potential). 
TOPO_DOM   1084   1459  376     Cytoplasmic (Potential). 
DOMAIN   41    130  90     SUEL-type lectin. 
DOMAIN   135    394  260     Olfactomedin-like. 
DOMAIN   784    836  53     GPS. 
SITE   824    825  2     Cleavage (By similarity). 
MOD_RES   1381   1381        Phosphoserine (By similarity). 
MOD_RES   1387   1387        Phosphoserine (By similarity). 
CARBOHYD   99     99        N-linked (GlcNAc...) (Potential). 
CARBOHYD   331    331        N-linked (GlcNAc...) (Potential). 
CARBOHYD   520    520        N-linked (GlcNAc...) (Potential). 
CARBOHYD   629    629        N-linked (GlcNAc...). 
CARBOHYD   731    731        N-linked (GlcNAc...) (Potential). 
CARBOHYD   744    744        N-linked (GlcNAc...) (Potential). 
CARBOHYD   787    787        N-linked (GlcNAc...) (Potential). 
CARBOHYD   792    792        N-linked (GlcNAc...) (Potential). 
CARBOHYD   813    813        N-linked (GlcNAc...) (Potential). 
DISULFID   136    318        By similarity. 
VAR_SEQ   595    607        Missing (in isoform 2, isoform 3 and isoform 4). VSP_010104
VAR_SEQ   1134   1136        SRI -> DIH (in isoform 3). VSP_010105
VAR_SEQ   1137   1459        Missing (in isoform 3). VSP_010106
VAR_SEQ   1167   1209        Missing (in isoform 2 and isoform 4). VSP_010107
VAR_SEQ   1210   1233        HSLNNARDTSAMDTLPLNGNFNNS -> LTSHGLRAHLQDLYHLELLLGQIA (in isoform 4). VSP_010108
VAR_SEQ   1234   1459        Missing (in isoform 4). VSP_010109
Sequence information
Length: 1459 AA [This is the length of the unprocessed precursor] Molecular weight: 163349 Da [This is the MW of the unprocessed precursor] CRC64: 30707B7C3C069029 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVSSGCRMRS LWFIIVISFL PNTEGFSRAA LPFGLVRREL SCEGYSIDLR CPGSDVIMIE 

        70         80         90        100        110        120 
SANYGRTDDK ICDADPFQME NTDCYLPDAF KIMTQRCNNR TQCIVVTGSD VFPDPCPGTY 

       130        140        150        160        170        180 
KYLEVQYECV PYIFVCPGTL KAIVDSPCIY EAEQKAGAWC KDPLQAADKI YFMPWTPYRT 

       190        200        210        220        230        240 
DTLIEYASLE DFQNSRQTTT YKLPNRVDGT GFVVYDGAVF FNKERTRNIV KFDLRTRIKS 

       250        260        270        280        290        300 
GEAIINYANY HDTSPYRWGG KTDIDLAVDE NGLWVIYATE QNNGMIVISQ LNPYTLRFEA 

       310        320        330        340        350        360 
TWETVYDKRA ASNAFMICGV LYVVRSVYQD NESETGKNSI DYIYNTRLNR GEYVDVPFPN 

       370        380        390        400        410        420 
QYQYIAAVDY NPRDNQLYVW NNNFILRYSL EFGPPDPAQV PTTAVTITSS AELFKTIIST 

       430        440        450        460        470        480 
TSTTSQKGPM STTVAGSQEG SKGTKPPPAV STTKIPPITN IFPLPERFCE ALDSKGIKWP 

       490        500        510        520        530        540 
QTQRGMMVER PCPKGTRGTA SYLCMISTGT WNPKGPDLSN CTSHWVNQLA QKIRSGENAA 

       550        560        570        580        590        600 
SLANELAKHT KGPVFAGDVS SSVRLMEQLV DILDAQLQEL KPSEKDSAGR SYNKLQKREK 

       610        620        630        640        650        660 
TCRAYLKAIV DTVDNLLRPE ALESWKHMNS SEQAHTATML LDTLEEGAFV LADNLLEPTR 

       670        680        690        700        710        720 
VSMPTENIVL EVAVLSTEGQ IQDFKFPLGI KGAGSSIQLS ANTVKQNSRN GLAKLVFIIY 

       730        740        750        760        770        780 
RSLGQFLSTE NATIKLGADF IGRNSTIAVN SHVISVSINK ESSRVYLTDP VLFTLPHIDP 

       790        800        810        820        830        840 
DNYFNANCSF WNYSERTMMG YWSTQGCKLV DTNKTRTTCA CSHLTNFAIL MAHREIAYKD 

       850        860        870        880        890        900 
GVHELLLTVI TWVGIVISLV CLAICIFTFC FFRGLQSDRN TIHKNLCINL FIAEFIFLIG 

       910        920        930        940        950        960 
IDKTKYAIAC PIFAGLLHFF FLAAFAWMCL EGVQLYLMLV EVFESEYSRK KYYYVAGYLF 

       970        980        990       1000       1010       1020 
PATVVGVSAA IDYKSYGTEK ACWLHVDNYF IWSFIGPVTF IILLNIIFLV ITLCKMVKHS 

      1030       1040       1050       1060       1070       1080 
NTLKPDSSRL ENIKSWVLGA FALLCLLGLT WSFGLLFINE ETIVMAYLFT IFNAFQGVFI 

      1090       1100       1110       1120       1130       1140 
FIFHCALQKK VRKEYGKCFR HSYCCGGLPT ESPHSSVKAS TTRTSARYSS GTQSRIRRMW 

      1150       1160       1170       1180       1190       1200 
NDTVRKQSES SFISGDINST STLNQGMTGN YLLTNPLLRP HGTNNPYNTL LAETVVCNAP 

      1210       1220       1230       1240       1250       1260 
SAPVFNSPGH SLNNARDTSA MDTLPLNGNF NNSYSLHKGD YNDSVQVVDC GLSLNDTAFE 

      1270       1280       1290       1300       1310       1320 
KMIISELVHN NLRGSSKTHN LELTLPVKPV IGGSSSEDDA IVADASSLMH SDNPGLELHH 

      1330       1340       1350       1360       1370       1380 
KELEAPLIPQ RTHSLLYQPQ KKVKSEGTDS YVSQLTAEAE DHLQSPNRDS LYTSMPNLRD 

      1390       1400       1410       1420       1430       1440 
SPYPESSPDM EEDLSPSRRS ENEDIYYKSM PNLGAGHQLQ MCYQISRGNS DGYIIPINKE 

      1450 
GCIPEGDVRE GQMQLVTSL 

O95490 in FASTA format

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