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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Leukemic T-cell;
DOI=10.1074/jbc.274.2.781; PubMed=9873016 [NCBI, ExPASy, EBI, Israel, Japan]
Takayama S.,
Xie Z.,
Reed J.C.;
"An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators.";
J. Biol. Chem. 274:781-786(1999).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH TNFRSF1A AND TNFRSF12.
TISSUE=Leukemic T-cell;
DOI=10.1126/science.283.5401.543; PubMed=9915703 [NCBI, ExPASy, EBI, Israel, Japan]
Jiang Y.,
Woronicz J.D.,
Liu W.,
Goeddel D.V.;
"Prevention of constitutive TNF receptor 1 signaling by silencer of death domains.";
Science 283:543-546(1999).
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[3]
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ERRATUM.
Jiang Y.,
Woronicz J.D.,
Liu W.,
Goeddel D.V.;
Science 283:1852-1852(1999).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[5]
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STRUCTURE BY NMR OF 376-457, INTERACTION WITH HSP70, AND MUTAGENESIS OF GLU-414; ASP-424; 438-ARG-LYS-439 AND GLN-446.
DOI=10.1074/jbc.M202792200; PubMed=12058034 [NCBI, ExPASy, EBI, Israel, Japan]
Briknarova K.,
Takayama S.,
Homma S.,
Baker K.,
Cabezas E.,
Hoyt D.W.,
Li Z.,
Satterthwait A.C.,
Ely K.R.;
"BAG4/SODD protein contains a short BAG domain.";
J. Biol. Chem. 277:31172-31178(2002).
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- FUNCTION: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling.
- SUBUNIT: Binds to the ATPase domain of HSP70/HSC chaperones. Binds to the death domain of TNFRSF1A in the absence of TNF and thereby prevents binding of adapter molecules such as TRADD or TRAF2. Binds to the death domain of TNFRSF12.
- SUBCELLULAR LOCATION: Cytoplasm.
- TISSUE SPECIFICITY: Ubiquitous.
- SIMILARITY: Contains 1 BAG domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 457 AA [This is the length of the unprocessed precursor] |
Molecular weight: 49594 Da [This is the MW of the unprocessed precursor] |
CRC64: B89D59E8118684A3 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MSALRRSGYG PSDGPSYGRY YGPGGGDVPV HPPPPLYPLR PEPPQPPISW RVRGGGPAET
70 80 90 100 110 120
TWLGEGGGGD GYYPSGGAWP EPGRAGGSHQ EQPPYPSYNS NYWNSTARSR APYPSTYPVR
130 140 150 160 170 180
PELQGQSLNS YTNGAYGPTY PPGPGANTAS YSGAYYAPGY TQTSYSTEVP STYRSSGNSP
190 200 210 220 230 240
TPVSRWIYPQ QDCQTEAPPL RGQVPGYPPS QNPGMTLPHY PYGDGNRSVP QSGPTVRPQE
250 260 270 280 290 300
DAWASPGAYG MGGRYPWPSS APSAPPGNLY MTESTSPWPS SGSPQSPPSP PVQQPKDSSY
310 320 330 340 350 360
PYSQSDQSMN RHNFPCSVHQ YESSGTVNND DSDLLDSQVQ YSAEPQLYGN ATSDHPNNQD
370 380 390 400 410 420
QSSSLPEECV PSDESTPPSI KKIIHVLEKV QYLEQEVEEF VGKKTDKAYW LLEEMLTKEL
430 440 450
LELDSVETGG QDSVRQARKE AVCKIQAILE KLEKKGL
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O95429 in FASTA format |
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ExPASy Home page
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