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UniProtKB/Swiss-Prot entry O95273


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CCDB1_HUMAN
Primary accession number O95273
Secondary accession numbers A8K3Q0 A8K3U2 Q6ZQN9 Q7Z519 Q8NBS7 Q8NBY2 Q9NS19 Q9NYH3 Q9UHX9
Integrated into Swiss-Prot on March 18, 2008
Sequence was last modified on March 18, 2008 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 34)
Name and origin of the protein
Protein name Cyclin-D1-binding protein 1
Synonyms Grap2 and cyclin-D-interacting protein
Human homolog of Maid
Gene name
Name: CCNDBP1
Synonyms: DIP1, GCIP, HHM
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CCND1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND PHOSPHORYLATION.
DOI=10.1006/excr.2000.4884; PubMed=10854051 [NCBI, ExPASy, EBI, Israel, Japan]
Yao Y., Doki Y., Jiang W., Imoto M., Venkatraj V.S., Warburton D., Santella R.M., Lu B., Yan L., Sun X.-H., Su T., Luo J., Weinstein I.B.;
"Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins.";
Exp. Cell Res. 257:22-32(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH TCF3, AND TISSUE SPECIFICITY.
TISSUE=Liver;
DOI=10.1053/jhep.2000.9092; PubMed=10915743 [NCBI, ExPASy, EBI, Israel, Japan]
Terai S., Aoki H., Thorgeirsson S.S.;
"Human homologue of maid: a dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression.";
Hepatology 32:357-366(2000).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CCND1 AND GRAP2, AND TISSUE SPECIFICITY.
TISSUE=Liver;
DOI=10.1074/jbc.M002598200; PubMed=10801854 [NCBI, ExPASy, EBI, Israel, Japan]
Xia C., Bao Z., Tabassam F., Ma W., Qiu M., Hua S., Liu M.;
"GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity.";
J. Biol. Chem. 275:20942-20948(2000).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Gao J., Yu L., Mao N.H., Wan Y.Z., Yang Y.M., Zhao S.Y.;
"Cloning and characterization of a novel human cDNA homologous to murine Maid mRNA.";
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
TISSUE=Hypothalamus;
DOI=10.1073/pnas.160270997; PubMed=10931946 [NCBI, ExPASy, EBI, Israel, Japan]
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.;
"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.";
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
TISSUE=Hair follicle dermal papilla, Lung, Retinoblastoma, and Trachea;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Placenta;
DOI=10.1093/dnares/12.2.117; PubMed=16303743 [NCBI, ExPASy, EBI, Israel, Japan]
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y., Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.;
"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.";
DNA Res. 12:117-126(2005).
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[10]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Pancreas;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[11]
INTERACTION WITH SYF2.
DOI=10.1006/bbrc.2000.3992; PubMed=11118353 [NCBI, ExPASy, EBI, Israel, Japan]
Chang M.-S., Chang C.-L., Huang C.-J., Yang Y.-C.;
"p29, a novel GCIP-interacting protein, localizes in the nucleus.";
Biochem. Biophys. Res. Commun. 279:732-737(2000).
[12]
TISSUE SPECIFICITY, AND INTERACTION WITH COPS5.
DOI=10.1053/j.gastro.2005.03.014; PubMed=15887118 [NCBI, ExPASy, EBI, Israel, Japan]
Takami T., Terai S., Yokoyama Y., Tanimoto H., Tajima K., Uchida K., Yamasaki T., Sakaida I., Nishina H., Thorgeirsson S.S., Okita K.;
"Human homologue of maid is a useful marker protein in hepatocarcinogenesis.";
Gastroenterology 128:1369-1380(2005).
[13]
INTERACTION WITH SIRT6, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
DOI=10.1002/jcb.21140; PubMed=17131381 [NCBI, ExPASy, EBI, Israel, Japan]
Ma W., Stafford L.J., Li D., Luo J., Li X., Ning G., Liu M.;
"GCIP/CCNDBP1, a helix-loop-helix protein, suppresses tumorigenesis.";
J. Cell. Biochem. 100:1376-1386(2007).
[14]
INTERACTION WITH RPLP0, AND SUBCELLULAR LOCATION.
DOI=10.1038/sj.onc.1210651; PubMed=17621266 [NCBI, ExPASy, EBI, Israel, Japan]
Chang T.-W., Chen C.-C., Chen K.-Y., Su J.-H., Chang J.-H., Chang M.-C.;
"Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells.";
Oncogene 27:332-338(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF082569; AAD11777.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF132034; AAF77613.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF246144; AAF67182.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF087852; AAP97163.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF113535; AAF14872.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR450331; CAG29327.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK075296; BAC11530.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK128849; BAC87645.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK290665; BAF83354.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK290707; BAF83396.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK075146; BAC11433.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471125; EAW92588.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471125; EAW92590.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC009689; AAH09689.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_036274.2; -.
NP_411241.1; -.
UniGene Hs.36794
3D structure databases
ModBase O95273.
Protein-protein interaction databases
IntAct O95273; -.
PTM databases
PhosphoSite O95273; -.
Organism-specific databases
HGNC HGNC:1587; CCNDBP1.
GenAtlas CCNDBP1.
MIM 607089; gene. [NCBI / EBI]
PharmGKB PA26154; -.
GeneCards O95273.
Gene expression databases
ArrayExpress O95273; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0005634; Cellular component: nucleus (inferred from direct assay from MGI).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0007049; Biological process: cell cycle (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
ProtoNet O95273.
Genome annotation databases
Ensembl ENSG00000166946; Homo sapiens. [Contig view]
GeneID 23582; -.
KEGG hsa:23582; -.
Phylogenomic databases
HOVERGEN O95273; -.
Other
NextBio 46190; -.
SOURCE CCNDBP1; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cell cycle; Cytoplasm; Nucleus; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   360  360     Cyclin-D1-binding protein 1. PRO_0000323372
REGION   1   208  208     Required for interaction with CCND1. 
REGION   1   190  190     Interaction with RPLP0. 
REGION   1   184  184     Interaction with TCF3. 
REGION   150   360  211     Interaction with TCF3. 
REGION   240   360  121     Interaction with RPLP0. 
VAR_SEQ   1   128        Missing (in isoform 3 and isoform 4). VSP_032012
VAR_SEQ   308   333        SAKLVSVLKKALEITKASHVTPQPED -> VSTGFEGIATEQMGRISLITSISCK (in isoform 4). VSP_032013
VAR_SEQ   308   309        SA -> EP (in isoform 2). VSP_032014
VAR_SEQ   310   360        Missing (in isoform 2). VSP_032015
VAR_SEQ   334   360        Missing (in isoform 4). VSP_032016
CONFLICT   40    40        A -> D (in Ref. 1; AAD11777). 
CONFLICT   41    41        Q -> R (in Ref. 4; AAP97163). 
CONFLICT   74    74        F -> S (in Ref. 8; BAC11433). 
CONFLICT   211   211        N -> S (in Ref. 8; BAC11433). 
CONFLICT   235   235        E -> G (in Ref. 7; BAF83396). 
CONFLICT   267   267        K -> R (in Ref. 7; BAC87645). 
CONFLICT   274   274        L -> M (in Ref. 1; AAD11777 and 3; AAF67182). 
CONFLICT   310   310        K -> R (in Ref. 7; BAC11530). 
CONFLICT   334   334        S -> I (in Ref. 7; BAF83354). 
Sequence information
Length: 360 AA [This is the length of the unprocessed precursor] Molecular weight: 40262 Da [This is the MW of the unprocessed precursor] CRC64: 40C7C3686632F6A7 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MASATAPAAA VPTLASPLEQ LRHLAEELRL LLPRVRVGEA QETTEEFNRE MFWRRLNEAA 

        70         80         90        100        110        120 
VTVSREATTL TIVFSQLPLP SPQETQKFCE QVHAAIKAFI AVYYLLPKDQ GITLRKLVRG 

       130        140        150        160        170        180 
ATLDIVDGMA QLMEVLSVTP TQSPENNDLI SYNSVWVACQ QMPQIPRDNK AAALLMLTKN 

       190        200        210        220        230        240 
VDFVKDAHEE MEQAVEECDP YSGLLNDTEE NNSDNHNHED DVLGFPSNQD LYWSEDDQEL 

       250        260        270        280        290        300 
IIPCLALVRA SKACLKKIRM LVAENGKKDQ VAQLDDIVDI SDEISPSVDD LALSIYPPMC 

       310        320        330        340        350        360 
HLTVRINSAK LVSVLKKALE ITKASHVTPQ PEDSWIPLLI NAIDHCMNRI KELTQSELEL 

O95273 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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