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UniProtKB/Swiss-Prot entry O95196


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CSPG5_HUMAN
Primary accession number O95196
Secondary accession numbers Q71M39 Q71M40
Integrated into Swiss-Prot on September 27, 2005
Sequence was last modified on May 5, 2009 (Sequence version 3)
Annotations were last modified on    June 16, 2009 (Entry version 67)
Name and origin of the protein
Protein name Chondroitin sulfate proteoglycan 5 [Precursor]
Synonyms Neuroglycan C
Acidic leucine-rich EGF-like domain-containing brain protein
Gene name
Name: CSPG5
Synonyms: CALEB, NGC
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND VARIANT VAL-188.
TISSUE=Brain;
DOI=10.1016/S0168-0102(98)00098-4; PubMed=9950058 [NCBI, ExPASy, EBI, Israel, Japan]
Yasuda Y., Tokita Y., Aono S., Matsui F., Ono T., Sonta S., Watanabe E., Nakanishi Y., Oohira A.;
"Cloning and chromosomal mapping of the human gene of neuroglycan C (NGC), a neural transmembrane chondroitin sulfate proteoglycan with an EGF module.";
Neurosci. Res. 32:313-322(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), AND VARIANT VAL-188.
Aono S., Tokita Y., Yamauchi S., Shuo T., Matsui F., Yasuda Y., Keino H., Shimada A., Kishikawa M., Asai M., Oohira A.;
"Expression of neuroglycan C (NGC), a transmembrane chondroitin sulfate proteoglycan with an EGF module, in the human brain.";
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04728; PubMed=16641997 [NCBI, ExPASy, EBI, Israel, Japan]
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
"The DNA sequence, annotation and analysis of human chromosome 3.";
Nature 440:1194-1198(2006).
[4]
INTERACTION WITH GOPC.
DOI=10.1074/jbc.M305577200; PubMed=12885772 [NCBI, ExPASy, EBI, Israel, Japan]
Hassel B., Schreff M., Stuebe E.-M., Blaich U., Schumacher S.;
"CALEB/NGC interacts with the Golgi-associated protein PIST.";
J. Biol. Chem. 278:40136-40143(2003).
[5]
INTERACTION WITH ERBB3, AND FUNCTION.
DOI=10.1016/j.bbrc.2004.07.066; PubMed=15358134 [NCBI, ExPASy, EBI, Israel, Japan]
Kinugasa Y., Ishiguro H., Tokita Y., Oohira A., Ohmoto H., Higashiyama S.;
"Neuroglycan C, a novel member of the neuregulin family.";
Biochem. Biophys. Res. Commun. 321:1045-1049(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF059274; AAC69612.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF461087; AAQ04774.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF461088; AAQ04775.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF461089; AAQ04776.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC099778; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AC112512; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
IPI IPI00008586; -.
IPI00651663; -.
IPI00651705; -.
RefSeq NP_006565.2; -.
UniGene Hs.45127
3D structure databases
ModBase O95196.
Protein-protein interaction databases
IntAct O95196; 1.
Organism-specific databases
GeneCards GC03M047578; -.
H-InvDB HIX0003276; -.
HGNC HGNC:2467; CSPG5.
GenAtlas CSPG5.
MIM 606775; gene. [NCBI / EBI]
PharmGKB PA26965; -.
Gene expression databases
ArrayExpress O95196; -.
Bgee O95196; -.
CleanEx HS_CSPG5; -.
GermOnline ENSG00000114646; Homo sapiens.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0030660; Cellular component: Golgi-associated vesicle membrane (inferred from direct assay from UniProtKB).
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0005624; Cellular component: membrane fraction (traceable author statement from ProtInc).
GO:0008083; Molecular function: growth factor activity (traceable author statement from UniProtKB).
GO:0030154; Biological process: cell differentiation (inferred from electronic annotation from UniProtKB-KW).
GO:0046907; Biological process: intracellular transport (traceable author statement from UniProtKB).
GO:0007399; Biological process: nervous system development (traceable author statement from UniProtKB).
GO:0040008; Biological process: regulation of growth (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR010555; Chon_Sulph_att.
IPR006210; EGF-like.
IPR013032; EGF-like_reg_CS.
IPR009505; Neural_ProG_Cyt.
Graphical view of domain structure.
Pfam PF06566; Chon_Sulph_att; 1.
PF06567; Neural_ProG_Cyt; 1.
Pfam graphical view of domain structure.
SMART SM00181; EGF; 1.
SMART graphical view of domain structure.
PROSITE PS00022; EGF_1; FALSE_NEG.
PS01186; EGF_2; FALSE_NEG.
PS50026; EGF_3; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
Ensembl ENSG00000114646; Homo sapiens. [Contig view]
GeneID 10675; -.
KEGG hsa:10675; -.
Phylogenomic databases
HOGENOM O95196; -.
HOVERGEN O95196; -.
Other
NextBio 40593; -.
SOURCE CSPG5; Homo sapiens.
ProtoNet O95196.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cell membrane; Developmental protein; Differentiation; Disulfide bond; EGF-like domain; Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Growth regulation; Membrane; Neurogenesis; Phosphoprotein; Polymorphism; Proteoglycan; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    30  30     Potential. 
CHAIN   31   566  536     Chondroitin sulfate proteoglycan 5. PRO_0000042151
TOPO_DOM   31   423  393     Extracellular (Potential). 
TRANSMEM   424   444  21     Potential. 
TOPO_DOM   445   566  122     Cytoplasmic (Potential). 
DOMAIN   371   413  43     EGF-like. 
REGION   264   301  38     Interaction with TNC and TNR (By similarity). 
REGION   442   460  19     Interaction with GOPC. 
CARBOHYD   57    57        N-linked (GlcNAc...) (Potential). 
CARBOHYD   59    59        O-linked (GalNAc...) (Potential). 
CARBOHYD   76    76        O-linked (GalNAc...) (Potential). 
CARBOHYD   117   117        O-linked (Xyl...) (chondroitin sulfate) (By similarity). 
CARBOHYD   147   147        O-linked (GalNAc...) (Potential). 
CARBOHYD   150   150        O-linked (GalNAc...) (Potential). 
CARBOHYD   154   154        O-linked (GalNAc...) (Potential). 
CARBOHYD   156   156        O-linked (GalNAc...) (Potential). 
CARBOHYD   162   162        O-linked (GalNAc...) (Potential). 
CARBOHYD   234   234        O-linked (GalNAc...) (Potential). 
CARBOHYD   313   313        O-linked (GalNAc...) (Potential). 
CARBOHYD   317   317        O-linked (GalNAc...) (Potential). 
CARBOHYD   328   328        O-linked (GalNAc...) (Potential). 
CARBOHYD   367   367        N-linked (GlcNAc...) (Potential). 
DISULFID   374   387        By similarity. 
DISULFID   381   397        By similarity. 
DISULFID   399   412        By similarity. 
VAR_SEQ   1   138        Missing (in isoform 3). VSP_015760
VAR_SEQ   487   513        Missing (in isoform 2 and isoform 3). VSP_015761
VARIANT   188   188  1     G -> V (in dbSNP:rs3732530 [NCBI]). VAR_055089 
VARIANT   417   417  1     T -> P (in dbSNP:rs34016925 [NCBI]). VAR_055090 
Sequence information
Length: 566 AA [This is the length of the unprocessed precursor] Molecular weight: 60016 Da [This is the MW of the unprocessed precursor] CRC64: DD8DA045C1BE31E5 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGRAGGGGPG RGPPPLLLFL GAALVLASGA VPAREAGSAV EAEELVKGSP AWEPPANDTR 

        70         80         90        100        110        120 
EEAGPPAAGE DEASWTAPGG ELAGPEEVLQ ESAAVTGTAW LEADSPGLGG VTAEAGSGDA 

       130        140        150        160        170        180 
QALPATLQAP HEVLGQSIMP PAIPEATEAS GPPSPTPGDK LSPASELPKE SPLEVWLNLG 

       190        200        210        220        230        240 
GSTPDPQGPE LTYPFQGTLE PQPASDIIDI DYFEGLDGEG RGADLGSFPG SPGTSENHPD 

       250        260        270        280        290        300 
TEGETPSWSL LDLYDDFTPF DESDFYPTTS FYDDLDEEEE EEEDDKDAVG GGDLEDENEL 

       310        320        330        340        350        360 
LVPTGKPGLG PGTGQPTSRW HAVPPQHTLG SVPGSSIALR PRPGEPGRDL ASSENGTECR 

       370        380        390        400        410        420 
SGFVRHNGSC RSVCDLFPSY CHNGGQCYLV ENIGAFCRCN TQDYIWHKGM RCESIITDFQ 

       430        440        450        460        470        480 
VMCVAVGSAA LVLLLLFMMT VFFAKKLYLL KTENTKLRRT NKFRTPSELH NDNFSLSTIA 

       490        500        510        520        530        540 
EGSHPNVRKL CNTPRTSSPH ARALAHYDNV ICQDDPSAPH KIQEVLKSCL KEEESFNIQN 

       550        560 
SMSPKLEGGK GDQADLDVNC LQNNLT 

O95196 in FASTA format

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