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UniProtKB/Swiss-Prot entry O94762


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name RECQ5_HUMAN
Primary accession number O94762
Secondary accession numbers Q9P1W7 Q9UNC8
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on August 30, 2002 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 91)
Name and origin of the protein
Protein name ATP-dependent DNA helicase Q5
Synonyms EC 3.6.1.-
RecQ protein-like 5
RecQ5
Gene name
Name: RECQL5
Synonyms: RECQ5
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
TISSUE=Testis;
DOI=10.1006/geno.1998.5595; PubMed=9878247 [NCBI, ExPASy, EBI, Israel, Japan]
Kitao S., Ohsugi I., Ichikawa K., Goto M., Furuichi Y., Shimamoto A.;
"Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes.";
Genomics 54:443-452(1998).
[2]
NUCLEOTIDE SEQUENCE (ISOFORMS ALPHA AND GAMMA).
DOI=10.1093/nar/27.18.3762; PubMed=10471747 [NCBI, ExPASy, EBI, Israel, Japan]
Sekelsky J.J., Brodsky M.H., Rubin G.M., Hawley R.S.;
"Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing.";
Nucleic Acids Res. 27:3762-3769(1999).
[3]
NUCLEOTIDE SEQUENCE (ISOFORMS ALPHA; BETA AND GAMMA), SUBCELLULAR LOCATION, AND INTERACTION WITH TOP3A AND TOP3B.
TISSUE=Testis;
DOI=10.1093/nar/28.7.1647; PubMed=10710432 [NCBI, ExPASy, EBI, Israel, Japan]
Shimamoto A., Nishikawa K., Kitao S., Furuichi Y.;
"Human RecQ5-beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3-alpha and 3-beta.";
Nucleic Acids Res. 28:1647-1655(2000).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GAMMA).
TISSUE=Duodenum;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-815, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB006533; BAA74454.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF135183; AAD43061.1; -; Unassigned_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF135183; AAD43062.1; -; Unassigned_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB042823; BAA95952.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB042824; BAA95953.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB042825; BAA95954.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC016911; AAH16911.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00185769; -.
IPI00220819; -.
IPI00220820; -.
RefSeq NP_001003715.1; -.
NP_001003716.1; -.
NP_004250.4; -.
UniGene Hs.632229
3D structure databases
ModBase O94762.
Protein-protein interaction databases
IntAct O94762; 14.
PTM databases
PhosphoSite O94762; -.
Organism-specific databases
GeneCards GC17M071134; -.
H-InvDB HIX0014182; -.
HGNC HGNC:9950; RECQL5.
GenAtlas RECQL5.
MIM 603781; gene. [NCBI / EBI]
PharmGKB PA34317; -.
Gene expression databases
ArrayExpress O94762; -.
Bgee O94762; -.
CleanEx HS_RECQL5; -.
GermOnline ENSG00000108469; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (non-traceable author statement from UniProtKB).
GO:0005654; Cellular component: nucleoplasm (non-traceable author statement from UniProtKB).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008026; Molecular function: ATP-dependent helicase activity (inferred from electronic annotation from InterPro).
GO:0003678; Molecular function: DNA helicase activity (non-traceable author statement from UniProtKB).
GO:0003676; Molecular function: nucleic acid binding (inferred from electronic annotation from InterPro).
GO:0006310; Biological process: DNA recombination (inferred from electronic annotation from InterPro).
GO:0006281; Biological process: DNA repair (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR014001; DEAD-like_N.
IPR001650; DNA/RNA_helicase_C.
IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
IPR002464; DNA/RNA_helicase_DEAH_CS.
IPR004589; DNA_helicase_ATP-dep_RecQ.
IPR018329; DNA_helicase_ATP-dep_RecQ_N.
IPR014021; Helicase_SF1/SF2_ATP-bd.
IPR010716; RecQ_helicase-like_5.
Graphical view of domain structure.
PANTHER PTHR13710; RecQ; 1.
Pfam PF00270; DEAD; 1.
PF00271; Helicase_C; 1.
PF06959; RecQ5; 1.
Pfam graphical view of domain structure.
SMART SM00487; DEXDc; 1.
SM00490; HELICc; 1.
SMART graphical view of domain structure.
TIGRFAMs TIGR00614; recQ_fam; 1.
PROSITE PS00690; DEAH_ATP_HELICASE; 1.
PS51192; HELICASE_ATP_BIND_1; 1.
PS51194; HELICASE_CTER; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE O94762; -.
Genome annotation databases
Ensembl ENSG00000108469; Homo sapiens. [Contig view]
GeneID 9400; -.
KEGG hsa:9400; -.
Phylogenomic databases
HOGENOM O94762; -.
HOVERGEN O94762; -.
OMA O94762; DIPPASH.
Other
NextBio 35211; -.
SOURCE RECQL5; Homo sapiens.
ProtoNet O94762.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; ATP-binding; Cytoplasm; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   991  991     ATP-dependent DNA helicase Q5. PRO_0000205055
DOMAIN   39   213  175     Helicase ATP-binding. 
DOMAIN   241   403  163     Helicase C-terminal. 
NP_BIND   52    59  8     ATP (Potential). 
MOTIF   157   160  4     DEAH box. 
MOD_RES   815   815        Phosphoserine. 
VAR_SEQ   411   991        Missing (in isoform Alpha). VSP_005568
VAR_SEQ   411   435        CRHAAIAKYFGDALPACAKGCDHCQ -> RWGRGHGKSLRAAWCSQVVSRHAEL (in isoform Gamma). VSP_005569
VAR_SEQ   436   991        Missing (in isoform Gamma). VSP_005570
VARIANT   480   480  1     D -> G (in dbSNP:rs820196 [NCBI]). VAR_024272 
VARIANT   628   628  1     S -> N (in dbSNP:rs35566780 [NCBI]). VAR_051733 
Sequence information
Length: 991 AA [This is the length of the unprocessed precursor] Molecular weight: 108858 Da [This is the MW of the unprocessed precursor] CRC64: 983668133DED865A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSSHHTTFPF DPERRVRSTL KKVFGFDSFK TPLQESATMA VVKGNKDVFV CMPTGAGKSL 

        70         80         90        100        110        120 
CYQLPALLAK GITIVVSPLI ALIQDQVDHL LTLKVRVSSL NSKLSAQERK ELLADLEREK 

       130        140        150        160        170        180 
PQTKILYITP EMAASSSFQP TLNSLVSRHL LSYLVVDEAH CVSQWGHDFR PDYLRLGALR 

       190        200        210        220        230        240 
SRLGHAPCVA LTATATPQVQ EDVFAALHLK KPVAIFKTPC FRANLFYDVQ FKELISDPYG 

       250        260        270        280        290        300 
NLKDFCLKAL GQEADKGLSG CGIVYCRTRE ACEQLAIELS CRGVNAKAYH AGLKASERTL 

       310        320        330        340        350        360 
VQNDWMEEKV PVIVATISFG MGVDKANVRF VAHWNIAKSM AGYYQESGRA GRDGKPSWCR 

       370        380        390        400        410        420 
LYYSRNDRDQ VSFLIRKEVA KLQEKRGNKA SDKATIMAFD ALVTFCEELG CRHAAIAKYF 

       430        440        450        460        470        480 
GDALPACAKG CDHCQNPTAV RRRLEALERS SSWSKTCIGP SQGNGFDPEL YEGGRKGYGD 

       490        500        510        520        530        540 
FSRYDEGSGG SGDEGRDEAH KREWNLFYQK QMQLRKGKDP KIEEFVPPDE NCPLKEASSR 

       550        560        570        580        590        600 
RIPRLTVKAR EHCLRLLEEA LSSNRQSTRT ADEADLRAKA VELEHETFRN AKVANLYKAS 

       610        620        630        640        650        660 
VLKKVADIHR ASKDGQPYDM GGSAKSCSAQ AEPPEPNEYD IPPASHVYSL KPKRVGAGFP 

       670        680        690        700        710        720 
KGSCPFQTAT ELMETTRIRE QAPQPERGGE HEPPSRPCGL LDEDGSEPLP GPRGEVPGGS 

       730        740        750        760        770        780 
AHYGGPSPEK KAKSSSGGSS LAKGRASKKQ QLLATAAHKD SQSIARFFCR RVESPALLAS 

       790        800        810        820        830        840 
APEAEGACPS CEGVQGPPMA PEKYTGEEDG AGGHSPAPPQ TEECLRERPS TCPPRDQGTP 

       850        860        870        880        890        900 
EVQPTPAKDT WKGKRPRSQQ ENPESQPQKR PRPSAKPSVV AEVKGSVSAS EQGTLNPTAQ 

       910        920        930        940        950        960 
DPFQLSAPGV SLKEAANVVV KCLTPFYKEG KFASKELFKG FARHLSHLLT QKTSPGRSVK 

       970        980        990 
EEAQNLIRHF FHGRARCESE ADWHGLCGPQ R 

O94762 in FASTA format

View entry in raw text format (no links)
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