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UniProtKB/Swiss-Prot entry O94671


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHOM_SCHPO
Primary accession number O94671
Secondary accession numbers None
Integrated into Swiss-Prot on September 26, 2001
Sequence was last modified on May 1, 1999 (Sequence version 1)
Annotations were last modified on    July 1, 2008 (Entry version 53)
Name and origin of the protein
Protein name Probable homoserine dehydrogenase
Synonyms EC 1.1.1.3
HDH
Gene name
ORFNames: SPBC776.03
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201, AND MASS SPECTROMETRY.
DOI=10.1021/pr7006335; PubMed=18257517 [NCBI, ExPASy, EBI, Israel, Japan]
Wilson-Grady J.T., Villen J., Gygi S.P.;
"Phosphoproteome analysis of fission yeast.";
J. Proteome Res. 7:1088-1097(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CU329671; CAA22876.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T40673; T40673.
RefSeq NP_596318.1; -.
3D structure databases
HSSP P31116; 1EBF. [HSSP ENTRY / PDB]
ModBase O94671.
Enzyme and pathway databases
BioCyc SPOM-XXX-01:SPOM-XXX-01-004336-MON; -.
Organism-specific databases
GeneDB_Spombe SPBC776.03; -.
Gene expression databases
ArrayExpress O94671; -.
Family and domain databases
InterPro IPR005106; Asp/hSer_DHase_NAD-bd.
IPR001342; hSer_DHase_cat.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00742; Homoserine_dh; 1.
PF03447; NAD_binding_3; 1.
Pfam graphical view of domain structure.
PROSITE PS01042; HOMOSER_DHGENASE; 1.
BLOCKS O94671.
Genome annotation databases
GeneID 2541148; -.
KEGG spo:SPBC776.03; -.
NMPDR fig|4896.1.peg.2184; -.
Other
ProtoNet O94671.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Isoleucine biosynthesis; Methionine biosynthesis; NADP; Oxidoreductase; Phosphoprotein; Threonine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   376  376     Probable homoserine dehydrogenase. PRO_0000066706
NP_BIND   13    20  8     NADP (By similarity). 
ACT_SITE   231   231        Proton donor (Potential). 
BINDING   99    99        NADP (By similarity). 
BINDING   123   123        NADP (By similarity). 
BINDING   216   216        Substrate (By similarity). 
MOD_RES   201   201        Phosphoserine. 
Sequence information
Length: 376 AA [This is the length of the unprocessed precursor] Molecular weight: 40037 Da [This is the MW of the unprocessed precursor] CRC64: 3A2BC3A2CBA9263C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSASRTNVNV AIVGTGNIGG ELLNQIKGFN ENASTNGTTS FNVVAISSME GHYVSKDYQP 

        70         80         90        100        110        120 
INLSEWKNLT SQNQGAYSLD ALVDFLAKSP LPAILVDNTA SEAIAQSYPK FLSKKINIAT 

       130        140        150        160        170        180 
PNKKAFSASN DVYQNIIKAS KESGALLMHE ASVGAGLPII STLKELIATG DEIIKIEGIF 

       190        200        210        220        230        240 
SGTLSYIFNV WSPNGKKGTA SFSDIVKIAK QNGYTEPDPR DDLNGMDVAR KVTILSRIAG 

       250        260        270        280        290        300 
VHVESASSFP VKSLIPEPLK SAVNAEEFLA GLPNFDSEFA SMREEAEKEG KVVRFVGEAD 

       310        320        330        340        350        360 
VANKTTLVKL EKYDASHPFA NLQSSDNIIS FTTKRYHTRP LVVIGAGAGA AVTAAGVLGD 

       370 
MIKIMSQVRA SDAPSA 

O94671 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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