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UniProtKB/Swiss-Prot entry O94296

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name YOOC_SCHPO
Primary accession number O94296
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on May 1, 1999 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 54)
Name and origin of the protein
Protein name Probable phospholipid-transporting ATPase C887.12
Synonym EC 3.6.3.1
Gene name
ORFNames: SPBC887.12
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
 SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
DOI=10.1038/nbt1222; PubMed=16823372 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.;
"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.";
Nat. Biotechnol. 24:841-847(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CU329671; CAA21897.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T40737; T40737.
RefSeq NP_596486.1; -.
3D structure databases
ModBase O94296.
Organism-specific databases
GeneDB_Spombe SPBC887.12; -.
Gene expression databases
ArrayExpress O94296; -.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005794; Cellular component: Golgi apparatus (inferred from electronic annotation from UniProtKB-KW).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0015662; Molecular function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism (inferred from electronic annotation from InterPro).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from InterPro).
GO:0004012; Molecular function: phospholipid-translocating ATPase activity (inferred from electronic annotation from InterPro).
GO:0008152; Biological process: metabolic process (inferred from electronic annotation from InterPro).
GO:0045332; Biological process: phospholipid translocation (traceable author statement from GeneDB_SPombe).
QuickGo view.
Family and domain databases
InterPro IPR001757; ATPase_P.
IPR005834; Dehalogen-like_hydro.
IPR006539; Flippase.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
Pfam PF00702; Hydrolase; 1.
Pfam graphical view of domain structure.
PRINTS PR00119; CATATPASE.
TIGRFAMs TIGR01652; ATPase-Plipid; 1.
TIGR01494; ATPase_P-type; 4.
PROSITE PS00154; ATPASE_E1_E2; 1.
ProtoNet O94296.
Genome annotation databases
GeneID 2541239; -.
KEGG spo:SPBC887.12; -.
NMPDR fig|4896.1.peg.2352; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Endoplasmic reticulum; Golgi apparatus; Hydrolase; Magnesium; Membrane; Nucleotide-binding; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1258  1258     Probable phospholipid-transporting ATPase C887.12. PRO_0000314112
TOPO_DOM   1    183  183     Cytoplasmic (By similarity). 
TRANSMEM   184    204  21     Potential. 
TOPO_DOM   205    208  4     Lumenal (By similarity). 
TRANSMEM   209    229  21     Potential. 
TOPO_DOM   230    406  177     Cytoplasmic (By similarity). 
TRANSMEM   407    427  21     Potential. 
TOPO_DOM   428    451  24     Lumenal (By similarity). 
TRANSMEM   452    472  21     Potential. 
TOPO_DOM   473    974  502     Cytoplasmic (By similarity). 
TRANSMEM   975    995  21     Potential. 
TOPO_DOM   996    998  3     Lumenal (By similarity). 
TRANSMEM   999   1019  21     Potential. 
TOPO_DOM   1020   1051  32     Cytoplasmic (By similarity). 
TRANSMEM   1052   1072  21     Potential. 
TOPO_DOM   1073   1086  14     Lumenal (By similarity). 
TRANSMEM   1087   1107  21     Potential. 
TOPO_DOM   1108   1115  8     Cytoplasmic (By similarity). 
TRANSMEM   1116   1136  21     Potential. 
TOPO_DOM   1137   1148  12     Lumenal (By similarity). 
TRANSMEM   1149   1169  21     Potential. 
TOPO_DOM   1170   1258  89     Cytoplasmic (By similarity). 
Sequence information
Length: 1258 AA [This is the length of the unprocessed precursor] Molecular weight: 142379 Da [This is the MW of the unprocessed precursor] CRC64: 9128B7BFD692B022 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MARDVDNKQN AKRISRDEDE DEFAGESMVG RTLDNPFLGE DEFEDIFGSE SQYISSSGQN 

        70         80         90        100        110        120 
STNPFLADTR IENSPLGSES KANQLNKQGT NVNHIEIPLR DFNDPTQPES FLPPPKNTFT 

       130        140        150        160        170        180 
SRIKKIKNLF KKEKKQVKPE DLGPRQIILN DYSANHFLHN AVSTCKYSAF TFLPKFLKEQ 

       190        200        210        220        230        240 
FSKYANLFFL FTAVVQQIPG ITPVNRYTTI GPMLIVLSVS GIKEIMEDIK RKKQDQELNE 

       250        260        270        280        290        300 
SPCYVLQGTG FVEKQWKDVV VGDIVKIVSE TFFPADLVLL SSSEPEGLCY IETANLDGET 

       310        320        330        340        350        360 
NLKIKQALPE TAGLLKPVEL GQLSGEVKSE QPNNNLYTFD ATLKLLPSDR ELPLSPDQLL 

       370        380        390        400        410        420 
LRGAQLRNTP WVYGIVVFTG HESKLMKNTT ETPIKRTSVE KQVNSQILFL LCIFVFLCFA 

       430        440        450        460        470        480 
SSLGALIHRS VYGSALSYVK YTSNRAGMFF KGLLTFWILY SNLVPISLFV TFELVRYIQA 

       490        500        510        520        530        540 
QLISSDLDMY NEETDTPAAC RTSSLVEELG QVGYIFSDKT GTLTRNQMEF RQCTIAGVAY 

       550        560        570        580        590        600 
ADVIPEDRQF TSEDLDSDMY IYDFDTLKEN LKHSENASLI HQFLLVLSIC HTVIPEYDES 

       610        620        630        640        650        660 
TNSIKYQASS PDEGALVKGA ASIGYKFLAR KPHLVTVSIF GKDESYELLH ICEFNSTRKR 

       670        680        690        700        710        720 
MSIVFRCPDG KIRLYVKGAD TVIMERLASD NPYLQTTIHH LEDYATVGLR TLCIAMREVP 

       730        740        750        760        770        780 
EDEYQRWSTV FETAASSLVD RAQKLMDAAE EIEKDLILLG ATAIEDRLQD GVPDTISTLQ 

       790        800        810        820        830        840 
TAGIKIWVLT GDRQETAINI GMSCKLIDED MGLVIVNEET KEATAESVMA KLSSIYRNEA 

       850        860        870        880        890        900 
TTGNVESMAL VIDGVSLTYA LDFSLERRFF ELASLCRAVI CCRVSPLQKA LIVKMVKRNT 

       910        920        930        940        950        960 
GEVLLAIGDG ANDVPMIQAA HVGVGISGME GLQAVRSSDF SISQFCYLKK LLLVHGSWCY 

       970        980        990       1000       1010       1020 
QRLSKLILYS FYKNIALYMT QFWYAFCNAF SGQVIFESWS ISLYNVLFTV LPPVVIGIFD 

      1030       1040       1050       1060       1070       1080 
QFVSAGQLFQ YPQLYQLGQR SEFFNLKRFW SWITNGFYHS LLLFLCSIAV FYYDGPNKDG 

      1090       1100       1110       1120       1130       1140 
LASGHWVWGT TLYAAILATV LGKAALISNH WTQYTVIATL GSFLLWIVFM PIYAVAAPAI 

      1150       1160       1170       1180       1190       1200 
GFSKEYYGII PHLYGNLKFW ASLLVLPTIA LMRDFVWKYS SRMYYPEEYH YVQEIQKYNV 

      1210       1220       1230       1240       1250 
TDYRPRIVGF HKAIRKIRQM QRMRKQRGYA FSQGEEDQSR ILDAYDTTHT RGAYGEMR
O94296 in FASTA format

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