NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH PAM, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
STRAIN=Sprague-Dawley;
DOI=10.1074/jbc.273.50.33524; PubMed=9837933 [NCBI, ExPASy, EBI, Israel, Japan]
Chen L., Johnson R.C., Milgram S.L.;
"P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes.";
J. Biol. Chem. 273:33524-33532(1998).

Comments

FUNCTION: May play a role in regulating vesicuar trafficking in cells.
SUBUNIT: Interacts with PAM.
INTERACTION:
P14925:Pam; NbExp=1; IntAct=EBI-1395057, EBI-1395008;
SUBCELLULAR LOCATION: Endosome. Note=Accumulates on perinuclear endosomes.
TISSUE SPECIFICITY: Testis, kidney, skeletal muscle, liver, lung, brain, heart, pituitary gland, adrenal gland and ovary.
SIMILARITY: Contains 1 Ras-associating domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF056208; AAD03249.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_075248.1; -.

UniGene

Rn.30013

3D structure databases

ModBase

O88869.

Protein-protein interaction databases

IntAct

O88869; -.

Organism-specific databases

RGD

621329; Pamci.

GeneLynx

Pamci; Rattus norvegicus.

Gene expression databases

ArrayExpress

O88869; -.

Ontologies

GO:0005515;	Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.

Family and domain databases

InterPro

IPR000159; Ras-assoc.
Graphical view of domain structure.

SMART

SM00314; RA; 1.
SMART graphical view of domain structure.

PROSITE

PS50200; RA; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

O88869.

Genome annotation databases

Ensembl

ENSRNOG00000038574; Rattus norvegicus. [Contig view]

GeneID

65053; -.

KEGG

rno:65053; -.

Phylogenomic databases

HOVERGEN

O88869; -.

Other

ProtoNet

O88869.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Coiled coil; Endosome.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 435`	`435`	`Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor.`	`PRO_0000299454`
`DOMAIN`	`25 119`	`95`	`Ras-associating.`
`COILED`	`195 291`	`97`	`Potential.`

Sequence information

Length: 435 AA [This is the length of the unprocessed precursor]

Molecular weight: 49545 Da [This is the MW of the unprocessed precursor]

CRC64: 582AF0C52176E9B1 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAPFGRNLLK TRHKNRSPTK DMDPEEKEIV VWVCQEEKIV CGLTKRTTSI DVIQALLEEH 

        70         80         90        100        110        120 
EATFGEKRFL LGKASDYCIV EKWRGSERAL PPLTRILKLW KAWGDEQPNM QFVLVKTDAF 

       130        140        150        160        170        180 
LPVPLWRTAE TKLVQNNEKP WELSPANYMK TLPPDKQKRI VRKTFRKLAK IRQDTGSHDR 

       190        200        210        220        230        240 
DNMECLVHLI ISQDHTIHQQ VQRMKELDME IEKCEAKIHL DRIGNDGADY VQEAYLMPRS 

       250        260        270        280        290        300 
SEEEQKLDFQ SEDNQTLEDL NDGEGVSQLE EQLQYYRALI DKLSAEIERE VKGAGTDGSE 

       310        320        330        340        350        360 
DMEGAAACEL ENSDLESVKC DLEKSMKAGL KIHSHLSGIQ REIKYSDSLL QMKAREYELL 

       370        380        390        400        410        420 
AKEFSSLHIS SKDGCQGKEN RGKEAEASSS NGEIPPLTQR VFNTYTNDTD SDTGISSNHS 

       430 
QDSETTLGDV LLLAT

O88869 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools