NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
DOI=10.1084/jem.188.3.451; PubMed=9687523 [NCBI, ExPASy, EBI, Israel, Japan]
Schaniel C., Pardali E., Sallusto F., Speletas M., Ruedl C., Shimizu T., Seidl T., Andersson J., Melchers F., Rolink A.G., Sideras P.;
"Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells.";
J. Exp. Med. 188:451-463(1998).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Salivary gland;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: Chemotactic for activated T-lymphocytes. May play an important role in the collaboration of dendritic cells and B-lymphocytes with T-cells in immune responses.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed by activated splenic B-lymphocytes and dendritic cells. Low expression in lung, thymocytes, lymph node, and unstimulated splenic cells.
SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF052505; AAC40200.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC012658; AAH12658.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00130912; -.

NP_033163.1; -.

3D structure databases

HSSP

Q98157; 1CM9. [HSSP ENTRY / PDB]

ModBase

O88430.

Organism-specific databases

MGI

MGI:1306779; Ccl22.

Gene expression databases

O88430; -.

O88430; -.

MM_CCL22; -.

ENSMUSG00000031779; Mus musculus.

Ontologies

GO:0005615;	Cellular component: extracellular space (inferred from electronic annotation from UniProtKB-KW).
GO:0008009;	Molecular function: chemokine activity (inferred from electronic annotation from InterPro).
GO:0006935;	Biological process: chemotaxis (inferred from electronic annotation from UniProtKB-KW).
GO:0006955;	Biological process: immune response (inferred from electronic annotation from InterPro).
GO:0006954;	Biological process: inflammatory response (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR002473; C-X-C/Interlkn_8.
IPR000827; CC_chemkine_sml_CS.
IPR001811; Chemokine_IL8.
Graphical view of domain structure.

Pfam

PF00048; IL8; 1.
Pfam graphical view of domain structure.

PRINTS

PR00436; INTERLEUKIN8.

SMART

SM00199; SCY; 1.
SMART graphical view of domain structure.

PROSITE

PS00472; SMALL_CYTOKINES_CC; 1.

Genome annotation databases

Ensembl

ENSMUSG00000031779; Mus musculus. [Contig view]

GeneID

20299; -.

KEGG

mmu:20299; -.

Phylogenomic databases

HOGENOM

O88430; -.

HOVERGEN

O88430; -.

OMA

O88430; VEDSICC.

Other

298033; -.

Ccl22; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Chemotaxis; Cytokine; Disulfide bond; Inflammatory response; Secreted; Signal.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 24`	`24`	`Potential.`
`CHAIN`	`25 92`	`68`	`C-C motif chemokine 22.`	`PRO_0000005228`
`DISULFID`	`36 60`		`By similarity.`
`DISULFID`	`37 76`		`By similarity.`

Sequence information

Length: 92 AA [This is the length of the unprocessed precursor]

Molecular weight: 10302 Da [This is the MW of the unprocessed precursor]

CRC64: 39859881CDAE07CA [This is a checksum on the sequence]

        10         20         30         40         50         60 
MATLRVPLLV ALVLLAVAIQ TSDAGPYGAN VEDSICCQDY IRHPLPSRLV KEFFWTSKSC 

        70         80         90 
RKPGVVLITV KNRDICADPR QVWVKKLLHK LS

O88430 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools