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UniProtKB/Swiss-Prot entry O87840

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SUCC2_STRCO
Primary accession number O87840
Secondary accession numbers None
Integrated into Swiss-Prot on May 27, 2002
Sequence was last modified on November 1, 1998 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 57)
Name and origin of the protein
Protein name Succinyl-CoA ligase [ADP-forming] subunit beta-2
Synonyms EC 6.2.1.5
Succinyl-CoA synthetase subunit beta-2
SCS-beta-2
Gene name
Name: sucC2
Synonyms: sucC
OrderedLocusNames: SCO6585
ORFNames: SC8A6.06
From
Streptomyces coelicolor [TaxID: 1902] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Streptomycineae; Streptomycetaceae; Streptomyces.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-471 / A3(2) / M145;
DOI=10.1038/417141a; PubMed=12000953 [NCBI, ExPASy, EBI, Israel, Japan]
Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).";
Nature 417:141-147(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL939128; CAA19778.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T35773; T35773.
RefSeq NP_630664.1; -.
3D structure databases
HSSP P07460; 1JKJ. [HSSP ENTRY / PDB]
ModBase O87840.
Enzyme and pathway databases
BioCyc SCOE100226:SCO6585-MON; -.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030145; Molecular function: manganese ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004775; Molecular function: succinate-CoA ligase (ADP-forming) activity (inferred from electronic annotation from HAMAP).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00558; -; 1.
PBIL [Tree]
InterPro IPR011761; ATP-grasp.
IPR013650; ATP-grasp_succ-CoA_synth-type.
IPR013816; ATP_grasp_subdomain_2.
IPR005809; CoA_lig_beta.
IPR005811; CoA_ligase.
IPR016102; Succinyl-CoA_synth-like.
Graphical view of domain structure.
Gene3D G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
G3DSA:3.40.50.261; Succinyl-CoA_synth-like; 1.
PANTHER PTHR11815; CoA_lig_beta; 1.
Pfam PF08442; ATP-grasp_2; 1.
PF00549; Ligase_CoA; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01016; sucCoAbeta; 1.
PROSITE PS50975; ATP_GRASP; 1.
PS01217; SUCCINYL_COA_LIG_3; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
GeneID 1102024; -.
GenomeReviews AL645882_GR; SCO6585.
KEGG sco:SCO6585; -.
NMPDR fig|100226.1.peg.6523; -.
Phylogenomic databases
HOGENOM O87840; -.
Genome annotation databases
CMR O87840; SCO6585.
Other
ProtoNet O87840.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Ligase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   383  383     Succinyl-CoA ligase [ADP-forming] subunit beta-2. PRO_0000102870
DOMAIN   9   231  223     ATP-grasp. 
NP_BIND   35   100  66     ATP (By similarity). 
METAL   185   185        Magnesium or manganese (By similarity). 
METAL   187   187        Magnesium or manganese (By similarity). 
Sequence information
Length: 383 AA [This is the length of the unprocessed precursor] Molecular weight: 40162 Da [This is the MW of the unprocessed precursor] CRC64: 5A3D05C0FD11DD03 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDLYEHQARE LFKEHGIVVP RAEVTDSPER AREIARALGG RAVVKAQVKT GGRGKAGGVR 

        70         80         90        100        110        120 
LAADPAEAEE AARHILGMDI RGHTVDTVML AEPCEIEREF YVSYVLDRAS GGFLAIASAE 

       130        140        150        160        170        180 
GGTEIEEVAA RRPEAVARIP VDPATGVHTA TAVRIADAAG LPPQTVDTLV RLWKVLVRED 

       190        200        210        220        230        240 
ALLVEVNPLV RTAEGRIVAL DGKVTLDDNA RFRQSRWGET RQEDADSLEA RAGAKGLNYV 

       250        260        270        280        290        300 
KLDGEVGVIG NGAGLVMSTL DVVAGCGARP ANFLDIGGGA SARVMADGLS VVLSDPDVRS 

       310        320        330        340        350        360 
VLVNVFGGIT ACDAVADGIV RALDEVRLTK PLVVRLDGNN AARGRALLDA RAHPLVEQAT 

       370        380 
TMDGAARRAA RLATAASTAG QAG
O87840 in FASTA format

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