ID   NUDC_PSEAE              Reviewed;         278 AA.
AC   O86062; Q9I2S2;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2001, sequence version 2.
DT   22-JUL-2008, entry version 56.
DE   RecName: Full=NADH pyrophosphatase;
DE            EC=3.6.1.22;
GN   Name=nudC; OrderedLocusNames=PA1823;
OS   Pseudomonas aeruginosa.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 29260 / PA103;
RA   Comolli J., Kang P.J., Engel J.N.;
RT   "fimL, a new gene involved in pilin biogenesis and function in
RT   Pseudomonas aeruginosa.";
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
RX   MEDLINE=20437337; PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T.,
RA   Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an
RT   opportunistic pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- CATALYTIC ACTIVITY: NAD(+) + H(2)O = AMP + NMN.
CC   -!- COFACTOR: Divalent ions. Magnesium or manganese (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family. NudC subfamily.
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DR   EMBL; AF083252; AAC34568.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG05212.1; -; Genomic_DNA.
DR   PIR; A83419; A83419.
DR   RefSeq; NP_250514.1; -.
DR   GeneID; 880282; -.
DR   GenomeReviews; AE004091_GR; PA1823.
DR   KEGG; pae:PA1823; -.
DR   NMPDR; fig|208964.1.peg.1824; -.
DR   PseudoCAP; PA1823; -.
DR   HOGENOM; O86062; -.
DR   BioCyc; PAER208964:PA1823-MON; -.
DR   LinkHub; O86062; -.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:HAMAP.
DR   GO; GO:0000210; F:NAD+ diphosphatase activity; IEA:HAMAP.
DR   HAMAP; MF_00297; -; 1.
DR   InterPro; IPR015375; NADH_PPase-like_N.
DR   InterPro; IPR000086; NUDIX_hydrolase_core.
DR   InterPro; IPR015376; Znr_NADH_PPase.
DR   Gene3D; G3DSA:3.90.79.10; NUDIX_hydrolase; 1.
DR   Pfam; PF00293; NUDIX; 1.
DR   Pfam; PF09296; NUDIX-like; 1.
DR   Pfam; PF09297; zf-NADH-PPase; 1.
DR   PRINTS; PR00502; NUDIXFAMILY.
DR   PROSITE; PS00893; NUDIX; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Magnesium; Manganese; NAD.
FT   CHAIN         1    278       NADH pyrophosphatase.
FT                                /FTId=PRO_0000056973.
FT   MOTIF       175    196       Nudix box.
FT   CONFLICT      2      2       A -> V (in Ref. 1; AAC34568).
FT   CONFLICT      5      5       F -> S (in Ref. 1; AAC34568).
FT   CONFLICT      9      9       A -> V (in Ref. 1; AAC34568).
FT   CONFLICT     74     74       E -> D (in Ref. 1; AAC34568).
SQ   SEQUENCE   278 AA;  31356 MW;  3CEBD80225D8753A CRC64;
     MAGEFRWQAG RPATAQVGGW VLAHCQQRFL QDDNGLLFPR EWLKRQELPL LAEHGVGHWQ
     GEPVYVLELD EPIELPGMAW APLRQFMLHG DFDQFCMLGY ASQIGIWARH NRFCGNCGTR
     MQAQDHERVM QCPQCGLHQY PRLSPSMIVL VTRGDEVLLA RSPRFVPGVY STLAGFVEAG
     ESVEQCVVRE VREEVGVEVA NLEYIGSQNW PFPHSLMLGF HAEYVSGEIV PQEDEIEDAQ
     WFSLDALPPL PAQRSIARHL IDLYLARRSG AAEPVLPG
//