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- FUNCTION: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity).
- CATALYTIC ACTIVITY: Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains.
- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
- SUBUNIT: Interacts with MAD2L1 and MUC1 (By similarity).
- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).
- DOMAIN: Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR (By similarity).
- PTM: The precursor is cleaved by a furin endopeptidase (By similarity).
- PTM: Phosphorylated (By similarity).
- SIMILARITY: Contains 1 peptidase M12B domain [view classification].
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 112 AA [This is the length of the partial sequence of the unprocessed precursor] |
Molecular weight: 12201 Da [This is the MW of the partial sequence of the unprocessed precursor] |
CRC64: B840FBE7C2EE69FC [This is a checksum on the sequence] |
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10 20 30 40 50 60
MLREQFSFDI AEEASKVCLA HLFTYQDFDM GTLGLAYVGS PRANSHGGVC PKAYYSPIGK
70 80 90 100 110
KNIYLNSGLT STKNYGKTIL TKEADLVTTH ELGHNFGAEH DPDGLAECAP NE
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O77636 in FASTA format |
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