[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. DOI=10.1038/sj.onc.1202510; PubMed=10321732 [NCBI, ExPASy, EBI, Israel, Japan] Hatakeyama S., Osawa M., Omine M., Ishikawa F.; "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation."; Oncogene 18:2085-2090(1999).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Mammary cancer, and Prostatic carcinoma; PubMed=10762645 [NCBI, ExPASy, EBI, Israel, Japan] Platica O., Chen S., Ivan E., Lopingco M.C., Holland J.F., Platica M.; "PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells."; Int. J. Oncol. 16:1055-1061(2000).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain; Mei G., Yu W., Gibbs R.A.; Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
[4]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Cervix, Lung, and Skin; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Expressed in all normal human tissues studied but overexpressed in most of their malignant counterparts.
SIMILARITY: Belongs to the JTB family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB016492; BAA33735.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB016488; BAA33731.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB016493; BAA33736.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF115850; AAD09822.2; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF131797; AAD20045.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000499; AAH00499.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000996; AAH00996.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC001363; AAH01363.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC001667; AAH01667.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC019277; AAH19277.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00008833; -.

NP_006685.1; -.

3D structure databases

ModBase

O76095.

Organism-specific databases

GC01M152213; -.

HGNC:6201; JTB.

JTB.

HPA006514; -.

604671; gene. [NCBI / EBI]

PharmGKB

PA30003; -.

Gene expression databases

Bgee

O76095; -.

CleanEx

HS_JTB; -.

GermOnline

ENSG00000143543; Homo sapiens.

Ontologies

GO:0005856;	Cellular component: cytoskeleton (inferred from direct assay from HPA).
GO:0005887;	Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0043231;	Cellular component: intracellular membrane-bounded organelle (inferred from direct assay from HPA).
GO:0005624;	Cellular component: membrane fraction (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR008657; JTB.
Graphical view of domain structure.

PANTHER

PTHR13041; JTB; 1.

Pfam

PF05439; JTB; 1.
Pfam graphical view of domain structure.

Proteomic databases

PRIDE

O76095; -.

Genome annotation databases

Ensembl

ENSG00000143543; Homo sapiens. [Contig view]

GeneID

10899; -.

KEGG

hsa:10899; -.

Phylogenomic databases

HOGENOM

O76095; -.

HOVERGEN

O76095; -.

OMA

O76095; TPECGST.

Other

41391; -.

JTB; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Membrane; Polymorphism; Signal; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 30`	`30`	`Potential.`
`CHAIN`	`31 146`	`116`	`Protein JTB.`	`PRO_0000021535`
`TOPO_DOM`	`31 105`	`75`	`Extracellular (Potential).`
`TRANSMEM`	`106 126`	`21`	`Potential.`
`TOPO_DOM`	`127 146`	`20`	`Cytoplasmic (Potential).`
`VARIANT`	`16 16`	`1`	`L -> F (in dbSNP:rs34686244 [NCBI]).`	`VAR_033994`

Sequence information

Length: 146 AA [This is the length of the unprocessed precursor]

Molecular weight: 16358 Da [This is the MW of the unprocessed precursor]

CRC64: CA7080543591C319 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLAGAGRPGL PQGRHLCWLL CAFTLKLCQA EAPVQEEKLS ASTSNLPCWL VEEFVVAEEC 

        70         80         90        100        110        120 
SPCSNFRAKT TPECGPTGYV EKITCSSSKR NEFKSCRSAL MEQRLFWKFE GAVVCVALIF 

       130        140 
ACLVIIRQRQ LDRKALEKVR KQIESI

O76095 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools