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UniProtKB/Swiss-Prot entry O75937


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DNJC8_HUMAN
Primary accession number O75937
Secondary accession numbers Q6IBA4 Q8N4Z5 Q9P051 Q9P067
Integrated into Swiss-Prot on September 19, 2002
Sequence was last modified on April 26, 2005 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 58)
Name and origin of the protein
Protein name DnaJ homolog subfamily C member 8
Synonym Splicing protein spf31
Gene name
Name: DNAJC8
Synonyms: SPF31
ORFNames: HSPC315, HSPC331
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
King A., Ajuh P., Schrotz-King P., Lamond A., Mann M.;
"spf31: a protein involved in splicing.";
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 96-253.
TISSUE=Umbilical cord blood;
Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.;
"Human partial CDS from CD34+ stem cells.";
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0611217104; PubMed=17287340 [NCBI, ExPASy, EBI, Israel, Japan]
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.";
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
[7]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF083190; AAC35352.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR456900; CAG33181.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL353354; CAI20826.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL353622; CAI20826.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL353622; CAI19135.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL353354; CAI19135.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC033159; AAH33159.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF161433; AAF28993.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF161449; AAF29009.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00003438; -.
RefSeq NP_055095.2; -.
UniGene Hs.433540
3D structure databases
HSSP P08622; 1BQZ. [HSSP ENTRY / PDB]
ModBase O75937.
Protein-protein interaction databases
IntAct O75937; 1.
Enzyme and pathway databases
Reactome REACT_1675; mRNA Processing.
REACT_71; Gene Expression.
Organism-specific databases
GeneCards GC01M028399; -.
HGNC HGNC:15470; DNAJC8.
GenAtlas DNAJC8.
PharmGKB PA27425; -.
Gene expression databases
ArrayExpress O75937; -.
Bgee O75937; -.
CleanEx HS_DNAJC8; -.
GermOnline ENSG00000126698; Homo sapiens.
Ontologies
GO
GO:0031072; Molecular function: heat shock protein binding (inferred from electronic annotation from InterPro).
GO:0000398; Biological process: nuclear mRNA splicing, via spliceosome (inferred from experiment from Reactome).
QuickGo view.
Family and domain databases
InterPro IPR001623; DnaJ_N.
IPR018253; Heat_shock_DnaJ_CS.
Graphical view of domain structure.
Gene3D G3DSA:1.10.287.110; DnaJ_N; 1.
Pfam PF00226; DnaJ; 1.
Pfam graphical view of domain structure.
SMART SM00271; DnaJ; 1.
SMART graphical view of domain structure.
PROSITE PS00636; DNAJ_1; FALSE_NEG.
PS50076; DNAJ_2; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE O75937; -.
Genome annotation databases
Ensembl ENSG00000126698; Homo sapiens. [Contig view]
GeneID 22826; -.
KEGG hsa:22826; -.
Phylogenomic databases
HOGENOM O75937; -.
HOVERGEN O75937; -.
OMA O75937; TYFNLNP.
Other
NextBio 43232; -.
ProtoNet O75937.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Chaperone; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   253  253     DnaJ homolog subfamily C member 8. PRO_0000071060
DOMAIN   57   124  68     J. 
MOD_RES   215   215        Phosphoserine. 
CONFLICT   253   253        E -> D (in Ref. 2; CAG33181). 
Sequence information
Length: 253 AA [This is the length of the unprocessed precursor] Molecular weight: 29842 Da [This is the MW of the unprocessed precursor] CRC64: C69D6189D69D1588 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAASGESGTS GGGGSTEEAF MTFYSEVKQI EKRDSVLTSK NQIERLTRPG SSYFNLNPFE 

        70         80         90        100        110        120 
VLQIDPEVTD EEIKKRFRQL SILVHPDKNQ DDADRAQKAF EAVDKAYKLL LDQEQKKRAL 

       130        140        150        160        170        180 
DVIQAGKEYV EHTVKERKKQ LKKEGKPTIV EEDDPELFKQ AVYKQTMKLF AELEIKRKER 

       190        200        210        220        230        240 
EAKEMHERKR QREEEIEAQE KAKREREWQK NFEESRDGRV DSWRNFQANT KGKKEKKNRT 

       250 
FLRPPKVKME QRE 

O75937 in FASTA format

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