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UniProtKB/Swiss-Prot entry O75912


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DGKI_HUMAN
Primary accession number O75912
Secondary accession numbers A4D1Q9 Q9NZ49
Integrated into Swiss-Prot on January 11, 2001
Sequence was last modified on November 1, 1998 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 81)
Name and origin of the protein
Protein name Diacylglycerol kinase iota
Synonyms DAG kinase iota
EC 2.7.1.107
Diglyceride kinase iota
DGK-iota
Gene name
Name: DGKI
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Retina;
DOI=10.1074/jbc.273.49.32746; PubMed=9830018 [NCBI, ExPASy, EBI, Israel, Japan]
Ding L., Traer E., McIntyre T.M., Zimmerman G.A., Prescott S.M.;
"The cloning and characterization of a novel human diacylglycerol kinase, DGK-iota.";
J. Biol. Chem. 273:32746-32752(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1083423; PubMed=12690205 [NCBI, ExPASy, EBI, Israel, Japan]
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.;
"Human chromosome 7: DNA sequence and biology.";
Science 300:767-772(2003).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 135-1065, AND VARIANT PHE-153.
PubMed=10706894 [NCBI, ExPASy, EBI, Israel, Japan]
Bowne S.J., Sullivan L.S., Ding L., Traer E., Prescott S.M., Birch D.G., Kennan A., Humphries P., Daiger S.P.;
"Evaluation of human diacylglycerol kinase iota, DGKI, a homolog of Drosophila rdgA, in inherited retinopathy mapping to 7q.";
Mol. Vis. 6:6-9(2000).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1049 AND TYR-1053, AND MASS SPECTROMETRY.
DOI=10.2116/analsci.24.161; PubMed=18187866 [NCBI, ExPASy, EBI, Israel, Japan]
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Anal. Sci. 24:161-166(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF061936; AAC62010.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH236950; EAL24051.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219939; AAF43006.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219907; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219908; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219909; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219910; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219911; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219912; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219913; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219914; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219915; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219916; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219917; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219918; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219919; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219920; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219921; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219922; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219923; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219924; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219925; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219926; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219927; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219928; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219929; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219930; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219931; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219932; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219933; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219934; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219935; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219936; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219937; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF219938; AAF43006.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00027380; -.
RefSeq NP_004708.1; -.
UniGene Hs.242947
3D structure databases
ModBase O75912.
Protein-protein interaction databases
IntAct O75912; 2.
PTM databases
PhosphoSite O75912; -.
Enzyme and pathway databases
BRENDA 2.7.1.107; 247.
Organism-specific databases
GeneCards GC07M136724; -.
H-InvDB HIX0078758; -.
HIX0078873; -.
HGNC HGNC:2855; DGKI.
GenAtlas DGKI.
MIM 604072; gene. [NCBI / EBI]
PharmGKB PA27316; -.
Gene expression databases
ArrayExpress O75912; -.
Bgee O75912; -.
CleanEx HS_DGKI; -.
GermOnline ENSG00000157680; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (traceable author statement from ProtInc).
GO:0005634; Cellular component: nucleus (traceable author statement from ProtInc).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004143; Molecular function: diacylglycerol kinase activity (traceable author statement from ProtInc).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0007205; Biological process: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway (inferred from electronic annotation from InterPro).
GO:0007242; Biological process: intracellular signaling cascade (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR002110; ANK.
IPR002219; DAG_PE_bd.
IPR000756; Diacylglycerol_kinase_access.
IPR001206; Diacylglycerol_kinase_cat.
Graphical view of domain structure.
Gene3D G3DSA:1.25.40.20; ANK; 1.
Pfam PF00023; Ank; 2.
PF00130; C1_1; 1.
PF00609; DAGK_acc; 1.
PF00781; DAGK_cat; 1.
Pfam graphical view of domain structure.
ProDom PD002939; DAGKa; 1.
PD005043; DAGKc; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00248; ANK; 2.
SM00109; C1; 2.
SM00045; DAGKa; 1.
SM00046; DAGKc; 1.
SMART graphical view of domain structure.
PROSITE PS50297; ANK_REP_REGION; 1.
PS50088; ANK_REPEAT; 2.
PS00479; ZF_DAG_PE_1; FALSE_NEG.
PS50081; ZF_DAG_PE_2; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE O75912; -.
Genome annotation databases
Ensembl ENSG00000157680; Homo sapiens. [Contig view]
GeneID 9162; -.
KEGG hsa:9162; -.
Phylogenomic databases
HOGENOM O75912; -.
HOVERGEN O75912; -.
OMA O75912; HKAACQR.
Other
NextBio 34367; -.
SOURCE DGKI; Homo sapiens.
ProtoNet O75912.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ANK repeat; ATP-binding; Cytoplasm; Kinase; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Repeat; Transferase; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1065  1065     Diacylglycerol kinase iota. PRO_0000218466
DOMAIN   376    500  125     DAGKc. 
REPEAT   958    990  33     ANK 1. 
REPEAT   997   1026  30     ANK 2. 
ZN_FING   178    232  55     Phorbol-ester/DAG-type 1. 
ZN_FING   251    309  59     Phorbol-ester/DAG-type 2. 
COMPBIAS   20     31  12     Poly-Ala. 
COMPBIAS   69     74  6     Poly-Ser. 
COMPBIAS   95    102  8     Poly-Ala. 
MOD_RES   1049   1049        Phosphoserine. 
MOD_RES   1053   1053        Phosphotyrosine. 
VARIANT   153    153  1     L -> F. VAR_010190 
CONFLICT   160    160        A -> P (in Ref. 3; AAF43006). 
Sequence information
Length: 1065 AA [This is the length of the unprocessed precursor] Molecular weight: 116997 Da [This is the MW of the unprocessed precursor] CRC64: B84971AA7630A799 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDAAGRGCHL LPLPAARGPA RAPAAAAAAA ASPPGPCSGA ACAPSAAAGA GAMNPSSSAG 

        70         80         90        100        110        120 
EEKGATGGSS SSGSGAGSCC LGAEGGADPR GAGSAAAAGA AALDEPAAAG QKEKDEALEE 

       130        140        150        160        170        180 
KLRNLTFRKQ VSYRKAISRA GLQHLAPAHP LSLPVANGPA KEPRATLDWS ENAVNGEHLW 

       190        200        210        220        230        240 
LETNVSGDLC YLGEENCQVR FAKSALRRKC AVCKIVVHTA CIEQLEKINF RCKPTFREGG 

       250        260        270        280        290        300 
SRSPRENFVR HHWVHRRRQE GKCKQCGKGF QQKFSFHSKE IVAISCSWCK QAFHNKVTCF 

       310        320        330        340        350        360 
MLHHIEEPCS LGAHAAVIVP PTWIIKVKKP QNSLKASNRK KKRTSFKRKA SKRGMEQENK 

       370        380        390        400        410        420 
GRPFVIKPIS SPLMKPLLVF VNPKSGGNQG TKVLQMFMWY LNPRQVFDLS QEGPKDALEL 

       430        440        450        460        470        480 
YRKVPNLRIL ACGGDGTVGW ILSILDELQL SPQPPVGVLP LGTGNDLART LNWGGGYTDE 

       490        500        510        520        530        540 
PVSKILCQVE DGTVVQLDRW NLHVERNPDL PPEELEDGVC KLPLNVFNNY FSLGFDAHVT 

       550        560        570        580        590        600 
LEFHESREAN PEKFNSRFRN KMFYAGAAFS DFLQRSSRDL SKHVKVVCDG TDLTPKIQEL 

       610        620        630        640        650        660 
KFQCIVFLNI PRYCAGTMPW GNPGDHHDFE PQRHDDGYIE VIGFTMASLA ALQVGGHGER 

       670        680        690        700        710        720 
LHQCREVMLL TYKSIPMQVD GEPCRLAPAM IRISLRNQAN MVQKSKRRTS MPLLNDPQSV 

       730        740        750        760        770        780 
PDRLRIRVNK ISLQDYEGFH YDKEKLREAS ISDWLRTIAG ELVQSFGAIP LGILVVRGDC 

       790        800        810        820        830        840 
DLETCRMYID RLQEDLQSVS SGSQRVHYQD HETSFPRALS AQRLSPRWCF LDDRSQEHLH 

       850        860        870        880        890        900 
FVMEISQDEI FILDPDMVVS QPAGTPPGMP DLVVEQASGI SDWWNPALRK RMLSDSGLGM 

       910        920        930        940        950        960 
IAPYYEDSDL KDLSHSRVLQ SPVSSEDHAI LQAVIAGDLM KLIESYKNGG SLLIQGPDHC 

       970        980        990       1000       1010       1020 
SLLHYAAKTG NGEIVKYILD HGPSELLDMA DSETGETALH KAACQRNRAV CQLLVDAGAS 

      1030       1040       1050       1060 
LRKTDSKGKT PQERAQQAGD PDLAAYLESR QNYKVIGHED LETAV 

O75912 in FASTA format

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