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UniProtKB/Swiss-Prot entry O75317


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name UBP12_HUMAN
Primary accession number O75317
Secondary accession numbers Q5VZV3 Q8TC49
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on November 28, 2006 (Sequence version 2)
Annotations were last modified on    December 16, 2008 (Entry version 68)
Name and origin of the protein
Protein name Ubiquitin carboxyl-terminal hydrolase 12
Synonyms EC 3.1.2.15
Ubiquitin thioesterase 12
Ubiquitin-specific-processing protease 12
Deubiquitinating enzyme 12
Ubiquitin-hydrolyzing enzyme 1
Gene name
Name: USP12
Synonyms: UBH1, USP12L1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1006/geno.1998.5275; PubMed=9615226 [NCBI, ExPASy, EBI, Israel, Japan]
Hansen-Hagge T.E., Janssen J.W.G., Hameister H., Papa F.R., Zechner U., Seriu T., Jauch A., Becke D., Hochstrasser M., Bartram C.R.;
"An evolutionarily conserved gene on human chromosome 5q33-q34, UBH1, encodes a novel deubiquitinating enzyme.";
Genomics 49:411-418(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02379; PubMed=15057823 [NCBI, ExPASy, EBI, Israel, Japan]
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
"The DNA sequence and analysis of human chromosome 13.";
Nature 428:522-528(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF022789; AAC23551.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL158062; CAH70555.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL355473; CAH70555.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL355473; CAI16331.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL158062; CAI16331.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC026072; AAH26072.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
UniGene Hs.42400
3D structure databases
HSSP Q93009; 1NBF. [HSSP ENTRY / PDB]
ModBase O75317.
Protein family/group databases
MEROPS C19.020; -.
C19.062; -.
Organism-specific databases
GeneCards GC13M026540; -.
H-InvDB HIX0011190; -.
HGNC HGNC:20485; USP12.
GenAtlas USP12.
MIM 603091; gene. [NCBI / EBI]
PharmGKB PA27522; -.
GeneCards O75317.
Gene expression databases
ArrayExpress O75317; -.
CleanEx HS_USP12; -.
GermOnline ENSG00000152484; Homo sapiens.
Ontologies
GO
GO:0008234; Molecular function: cysteine-type peptidase activity (inferred from electronic annotation from UniProtKB-KW).
GO:0004221; Molecular function: ubiquitin thiolesterase activity (traceable author statement from UniProtKB).
GO:0006464; Biological process: protein modification process (non-traceable author statement from UniProtKB).
GO:0006511; Biological process: ubiquitin-dependent protein catabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001394; Peptidase_C19.
Graphical view of domain structure.
Pfam PF00443; UCH; 1.
Pfam graphical view of domain structure.
PROSITE PS00972; UCH_2_1; 1.
PS00973; UCH_2_2; 1.
PS50235; UCH_2_3; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
Ensembl ENSG00000152484; Homo sapiens. [Contig view]
KEGG hsa:219333; -.
Phylogenomic databases
HOGENOM O75317; -.
HOVERGEN O75317; -.
Other
LinkHub O75317; -.
NextBio 90574; -.
SOURCE USP12; Homo sapiens.
ProtoNet O75317.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Hydrolase; Protease; Thiol protease; Ubl conjugation pathway.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   370  370     Ubiquitin carboxyl-terminal hydrolase 12. PRO_0000080634
ACT_SITE   48    48        By similarity. 
ACT_SITE   308   308        By similarity. 
ACT_SITE   317   317        By similarity. 
CONFLICT   173   173        H -> D (in Ref. 3; AAH26072). 
Sequence information
Length: 370 AA [This is the length of the unprocessed precursor] Molecular weight: 42858 Da [This is the MW of the unprocessed precursor] CRC64: 267EE6A3674F6440 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEILMTVSKF ASICTMGANA SALEKEIGPE QFPVNEHYFG LVNFGNTCYC NSVLQALYFC 

        70         80         90        100        110        120 
RPFREKVLAY KSQPRKKESL LTCLADLFHS IATQKKKVGV IPPKKFITRL RKENELFDNY 

       130        140        150        160        170        180 
MQQDAHEFLN YLLNTIADIL QEERKQEKQN GRLPNGNIDN ENNNSTPDPT WVHEIFQGTL 

       190        200        210        220        230        240 
TNETRCLTCE TISSKDEDFL DLSVDVEQNT SITHCLRGFS NTETLCSEYK YYCEECRSKQ 

       250        260        270        280        290        300 
EAHKRMKVKK LPMILALHLK RFKYMDQLHR YTKLSYRVVF PLELRLFNTS GDATNPDRMY 

       310        320        330        340        350        360 
DLVAVVVHCG SGPNRGHYIA IVKSHDFWLL FDDDIVEKID AQAIEEFYGL TSDISKNSES 

       370 
GYILFYQSRD 

O75317 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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