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UniProtKB/Swiss-Prot entry O75165


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DJC13_HUMAN
Primary accession number O75165
Secondary accession numbers Q3L0T1 Q6PI82 Q6UJ77 Q6ZSW1 Q6ZUT5 Q86XG3 Q96DC1 Q9BWK9
Integrated into Swiss-Prot on April 13, 2004
Sequence was last modified on November 25, 2008 (Sequence version 4)
Annotations were last modified on    May 5, 2009 (Entry version 66)
Name and origin of the protein
Protein name DnaJ homolog subfamily C member 13
Synonyms Required for receptor-mediated endocytosis 8
RME-8
Gene name
Name: DNAJC13
Synonyms: KIAA0678, RME8
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALA-1463.
DOI=10.1074/jbc.M505036200; PubMed=16179350 [NCBI, ExPASy, EBI, Israel, Japan]
Girard M., Poupon V., Blondeau F., McPherson P.S.;
"The DnaJ-domain protein RME-8 functions in endosomal trafficking.";
J. Biol. Chem. 280:40135-40143(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1093/dnares/5.3.169; PubMed=9734811 [NCBI, ExPASy, EBI, Israel, Japan]
Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.";
DNA Res. 5:169-176(1998).
[3]
SEQUENCE REVISION.
TISSUE=Aortic endothelium;
Ohara O., Nagase T., Kikuno R., Ishikawa K., Suyama M.;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-747 AND 1819-2243.
TISSUE=Cervix, Placenta, and Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 617-2243.
TISSUE=Brain;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 672-1098.
Chang H.C., Hull M.J., Mellman I.;
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1843, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0404720101; PubMed=15302935 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1701, AND MASS SPECTROMETRY.
DOI=10.2116/analsci.24.161; PubMed=18187866 [NCBI, ExPASy, EBI, Israel, Japan]
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Anal. Sci. 24:161-166(2008).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2151, AND MASS SPECTROMETRY.
DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan]
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
[10]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
Comments
  • SIMILARITY: Contains 1 J domain.
  • SEQUENCE CAUTION:
    • Sequence=AAH43583.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 748
    • Sequence=BAC86835.1; Type=Erroneous termination; Positions=1651; Note=Translated as Glu
    • Sequence=BAC86835.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY779857; AAV41096.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB014578; BAA31653.2; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000164; AAH00164.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC009630; AAH09630.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC040638; AAH40638.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC043583; AAH43583.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK125330; BAC86133.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK127112; BAC86835.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY369172; AAQ57271.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00307259; -.
PIR T00361; T00361.
RefSeq NP_056083.3; -.
UniGene Hs.12707
3D structure databases
ModBase O75165.
PTM databases
PhosphoSite O75165; -.
Organism-specific databases
GeneCards GC03P133665; -.
HGNC HGNC:30343; DNAJC13.
GenAtlas DNAJC13.
PharmGKB PA134947358; -.
HUGE KIAA0678.
Gene expression databases
ArrayExpress O75165; -.
Bgee O75165; -.
CleanEx HS_DNAJC13; -.
GermOnline ENSG00000138246; Homo sapiens.
Ontologies
GO
GO:0031072; Molecular function: heat shock protein binding (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001623; DnaJ_N.
IPR018253; Heat_shock_DnaJ_CS.
IPR015609; Hsp40/DnaJ_Rel.
Graphical view of domain structure.
Gene3D G3DSA:1.10.287.110; DnaJ_N; 1.
PANTHER PTHR11821; Hsp40/DnaJ_Rel; 1.
Pfam PF00226; DnaJ; 1.
Pfam graphical view of domain structure.
SMART SM00271; DnaJ; 1.
SMART graphical view of domain structure.
PROSITE PS00636; DNAJ_1; FALSE_NEG.
PS50076; DNAJ_2; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE O75165; -.
Genome annotation databases
Ensembl ENSG00000138246; Homo sapiens. [Contig view]
GeneID 23317; -.
KEGG hsa:23317; -.
Phylogenomic databases
HOVERGEN O75165; -.
Other
ProtoNet O75165.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Chaperone; Phosphoprotein; Polymorphism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   2243  2243     DnaJ homolog subfamily C member 13. PRO_0000071072
DOMAIN   1301   1366  66     J. 
MOD_RES   1701   1701        Phosphothreonine. 
MOD_RES   1843   1843        Phosphoserine. 
MOD_RES   2151   2151        Phosphoserine. 
VARIANT   1463   1463  1     S -> A (in dbSNP:rs3762672 [NCBI]). VAR_047458 
VARIANT   1487   1487  1     F -> C (in dbSNP:rs4405917 [NCBI]). VAR_047459 
VARIANT   1995   1995  1     V -> I (in dbSNP:rs10935014 [NCBI]). VAR_047460 
CONFLICT   476    476        D -> E (in Ref. 3; BAA31653). 
CONFLICT   562    562        N -> D (in Ref. 4; AAH43583). 
CONFLICT   1097   1097        I -> T (in Ref. 5; BAC86133). 
CONFLICT   1148   1148        T -> I (in Ref. 5; BAC86835). 
CONFLICT   1227   1227        Q -> H (in Ref. 3; BAA31653). 
CONFLICT   1230   1230        T -> A (in Ref. 5; BAC86835). 
CONFLICT   1269   1269        D -> N (in Ref. 5; BAC86133). 
CONFLICT   2041   2041        L -> P (in Ref. 5; BAC86835). 
CONFLICT   2091   2091        T -> A (in Ref. 5; BAC86835). 
Sequence information
Length: 2243 AA [This is the length of the unprocessed precursor] Molecular weight: 254431 Da [This is the MW of the unprocessed precursor] CRC64: 5EF0378B6E5FF807 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNIIRENKDL ACFYTTKHSW RGKYKRVFSV GTHAITTYNP NTLEVTNQWP YGDICSISPV 

        70         80         90        100        110        120 
GKGQGTEFNL TFRKGSGKKS ETLKFSTEHR TELLTEALRF RTDFSEGKIT GRRYNCYKHH 

       130        140        150        160        170        180 
WSDSRKPVIL EVTPGGFDQI NPATNRVLCS YDYRNIEGFV DLSDYQGGFC ILYGGFSRLH 

       190        200        210        220        230        240 
LFASEQREEI IKSAIDHAGN YIGISLRIRK EPLEFEQYLN LRFGKYSTDE SITSLAEFVV 

       250        260        270        280        290        300 
QKISPRHSEP VKRVLALTET CLVERDPATY NIATLKPLGE VFALVCDSEN PQLFTIEFIK 

       310        320        330        340        350        360 
GQVRKYSSTE RDSLLASLLD GVRASGNRDV CVKMTPTHKG QRWGLLSMPV DEEVESLHLR 

       370        380        390        400        410        420 
FLATPPNGNF ADAVFRFNAN ISYSGVLHAV TQDGLFSENK EKLINNAITA LLSQEGDVVA 

       430        440        450        460        470        480 
SNAELESQFQ AVRRLVASKA GFLAFTQLPK FRERLGVKVV KALKRSNNGI IHAAVDMLCA 

       490        500        510        520        530        540 
LMCPMHDDYD LRQEQLNKAS LLSSKKFLEN LLEKFNSHVD HGTGALVISS LLDFLTFALC 

       550        560        570        580        590        600 
APYSETTEGQ QFDMLLEMVA SNGRTLFKLF QHPSMAIIKG AGLVMKAIIE EGDKEIATKM 

       610        620        630        640        650        660 
QELALSEGAL PRHLHTAMFT ISSDQRMLTN RQLSRHLVGL WTADNATATN LLKRILPPGL 

       670        680        690        700        710        720 
LAYLESSDLV PEKDADRMHV RDNVKIAMDQ YGKFNKVPEW QRLAGKAAKE VEKFAKEKVD 

       730        740        750        760        770        780 
LVLMHWRDRM GIAQKENINQ KPVVLRKRRQ RIKIEANWDL FYYRFGQDHA RSNLIWNFKT 

       790        800        810        820        830        840 
REELKDTLES EMRAFNIDRE LGSANVISWN HHEFEVKYEC LAEEIKIGDY YLRLLLEEDE 

       850        860        870        880        890        900 
NEESGSIKRS YEFFNELYHR FLLTPKVNMK CLCLQALAIV YGRCHEEIGP FTDTRYIIGM 

       910        920        930        940        950        960 
LERCTDKLER DRLILFLNKL ILNKKNVKDL MDSNGIRILV DLLTLAHLHV SRATVPLQSN 

       970        980        990       1000       1010       1020 
VIEAAPDMKR ESEKEWYFGN ADKERSGPYG FHEMQELWTK GMLNAKTRCW AQGMDGWRPL 

      1030       1040       1050       1060       1070       1080 
QSIPQLKWCL LASGQAVLNE TDLATLILNM LITMCGYFPS RDQDNAIIRP LPKVKRLLSD 

      1090       1100       1110       1120       1130       1140 
STCLPHIIQL LLTFDPILVE KVAILLYHIM QDNPQLPRLY LSGVFFFIMM YTGSNVLPVA 

      1150       1160       1170       1180       1190       1200 
RFLKYTHTKQ AFKSEETKGQ DIFQRSILGH ILPEAMVCYL ENYEPEKFSE IFLGEFDTPE 

      1210       1220       1230       1240       1250       1260 
AIWSSEMRRL MIEKIAAHLA DFTPRLQSNT RALYQYCPIP IINYPQLENE LFCNIYYLKQ 

      1270       1280       1290       1300       1310       1320 
LCDTLRFPDW PIKDPVKLLK DTLDAWKKEV EKKPPMMSID DAYEVLNLPQ GQGPHDESKI 

      1330       1340       1350       1360       1370       1380 
RKAYFRLAQK YHPDKNPEGR DMFEKVNKAY EFLCTKSAKI VDGPDPENII LILKTQSILF 

      1390       1400       1410       1420       1430       1440 
NRHKEDLQPY KYAGYPMLIR TITMETSDDL LFSKESPLLP AATELAFHTV NCSALNAEEL 

      1450       1460       1470       1480       1490       1500 
RRENGLEVLQ EAFSRCVAVL TRSSKPSDMS VQVCGYISKC YSVAAQFEEC REKITEMPSI 

      1510       1520       1530       1540       1550       1560 
IKDLCRVLYF GKSIPRVAAL GVECVSSFAV DFWLQTHLFQ AGILWYLLGF LFNYDYTLEE 

      1570       1580       1590       1600       1610       1620 
SGIQKSEETN QQEVANSLAK LSVHALSRLG GYLAEEQATP ENPTIRKSLA GMLTPYVARK 

      1630       1640       1650       1660       1670       1680 
LAVASVTEIL KMLNSNTESP YLIWNNSTRA ELLEFLESQQ ENMIKKGDCD KTYGSEFVYS 

      1690       1700       1710       1720       1730       1740 
DHAKELIVGE IFVRVYNEVP TFQLEVPKAF AASLLDYIGS QAQYLHTFMA ITHAAKVESE 

      1750       1760       1770       1780       1790       1800 
QHGDRLPRVE MALEALRNVI KYNPGSESEC IGHFKLIFSL LRVHGAGQVQ QLALEVVNIV 

      1810       1820       1830       1840       1850       1860 
TSNQDCVNNI AESMVLSSLL ALLHSLPSSR QLVLETLYAL TSSTKIIKEA MAKGALIYLL 

      1870       1880       1890       1900       1910       1920 
DMFCNSTHPQ VRAQTAELFA KMTADKLIGP KVRITLMKFL PSVFMDAMRD NPEAAVHIFE 

      1930       1940       1950       1960       1970       1980 
GTHENPELIW NDNSRDKVST TVREMMLEHF KNQQDNPEAN WKLPEDFAVV FGEAEGELAV 

      1990       2000       2010       2020       2030       2040 
GGVFLRIFIA QPAWVLRKPR EFLIALLEKL TELLEKNNPH GETLETLTMA TVCLFSAQPQ 

      2050       2060       2070       2080       2090       2100 
LADQVPPLGH LPKVIQAMNH RNNAIPKSAI RVIHALSENE LCVRAMASLE TIGPLMNGMK 

      2110       2120       2130       2140       2150       2160 
KRADTVGLAC EAINRMFQKE QSELVAQALK ADLVPYLLKL LEGIGLENLD SPAATKAQIV 

      2170       2180       2190       2200       2210       2220 
KALKAMTRSL QYGEQVNEIL CRSSVWSAFK DQKHDLFISE SQTAGYLTGP GVAGYLTAGT 

      2230       2240 
STSVMSNLPP PVDHEAGDLG YQT 

O75165 in FASTA format

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