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UniProtKB/Swiss-Prot entry O75061


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AUXI_HUMAN
Primary accession number O75061
Secondary accession numbers Q32M66 Q4G0K1 Q5T614 Q5T615
Integrated into Swiss-Prot on June 27, 2006
Sequence was last modified on June 27, 2006 (Sequence version 3)
Annotations were last modified on    May 5, 2009 (Entry version 67)
Name and origin of the protein
Protein name Putative tyrosine-protein phosphatase auxilin
Synonyms EC 3.1.3.48
DnaJ homolog subfamily C member 6
Gene name
Name: DNAJC6
Synonyms: KIAA0473
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
DOI=10.1093/dnares/4.5.345; PubMed=9455484 [NCBI, ExPASy, EBI, Israel, Japan]
Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.;
"Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.";
DNA Res. 4:345-349(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-563; SER-566; THR-567 AND SER-570, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB007942; BAA32318.2; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL139294; CAI18997.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL355487; CAI18997.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC119800; CAI18997.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL139294; CAI18999.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL355487; CAI18999.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC119800; CAI18999.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL355487; CAI23547.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC119800; CAI23547.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL139294; CAI23547.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL355487; CAI23548.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC119800; CAI23548.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL139294; CAI23548.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC051722; AAH51722.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC109279; AAI09280.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC109280; AAI09281.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00184119; -.
IPI00639806; -.
IPI00760699; -.
RefSeq NP_055602.1; -.
UniGene Hs.647643
3D structure databases
HSSP Q27974; 1NZ6. [HSSP ENTRY / PDB]
SMR O75061; 733-913.
ModBase O75061.
PTM databases
PhosphoSite O75061; -.
Enzyme and pathway databases
BRENDA 3.1.3.48; 247.
Reactome REACT_11123; Membrane Trafficking.
Organism-specific databases
GeneCards GC01P065487; -.
HGNC HGNC:15469; DNAJC6.
GenAtlas DNAJC6.
MIM 608375; gene. [NCBI / EBI]
PharmGKB PA27423; -.
HUGE KIAA0473.
Gene expression databases
ArrayExpress O75061; -.
Bgee O75061; -.
CleanEx HS_DNAJC6; -.
GermOnline ENSG00000116675; Homo sapiens.
Ontologies
GO
GO:0031072; Molecular function: heat shock protein binding (inferred from electronic annotation from InterPro).
GO:0004725; Molecular function: protein tyrosine phosphatase activity (inferred from electronic annotation from EC).
GO:0017124; Molecular function: SH3 domain binding (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001623; DnaJ_N.
IPR018253; Heat_shock_DnaJ_CS.
IPR014019; Phosphatase_tensin-typ.
IPR014020; Tensin_phosphatase_C2-dom.
Graphical view of domain structure.
Gene3D G3DSA:1.10.287.110; DnaJ_N; 1.
Pfam PF00226; DnaJ; 1.
PF10409; PTEN_C2; 1.
Pfam graphical view of domain structure.
SMART SM00271; DnaJ; 1.
SMART graphical view of domain structure.
PROSITE PS51182; C2_TENSIN; 1.
PS00636; DNAJ_1; FALSE_NEG.
PS50076; DNAJ_2; 1.
PS51181; PPASE_TENSIN; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE O75061; -.
Genome annotation databases
Ensembl ENSG00000116675; Homo sapiens. [Contig view]
GeneID 9829; -.
KEGG hsa:9829; -.
Phylogenomic databases
HOVERGEN O75061; -.
OMA O75061; CTDFERM.
Other
NextBio 37030; -.
SOURCE DNAJC6; Homo sapiens.
ProtoNet O75061.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Chaperone; Hydrolase; Phosphoprotein; Polymorphism; Protein phosphatase; Repeat; SH3-binding.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   913  913     Putative tyrosine-protein phosphatase auxilin. PRO_0000244516
REPEAT   36    39  4     1. 
REPEAT   40    43  4     2. 
REPEAT   44    47  4     3. 
DOMAIN   55   222  168     Phosphatase tensin-type. 
DOMAIN   228   366  139     C2 tensin-type. 
DOMAIN   849   913  65     J. 
REGION   36    47  12     3 X 4 AA approximate tandem repeats. 
MOTIF   409   417  9     SH3-binding (Potential). 
COMPBIAS   466   760  295     Pro-rich. 
COMPBIAS   529   532  4     Poly-Gly. 
ACT_SITE   164   164        Phosphocysteine intermediate (Potential). 
MOD_RES   563   563        Phosphoserine. 
MOD_RES   566   566        Phosphoserine. 
MOD_RES   567   567        Phosphothreonine. 
MOD_RES   570   570        Phosphoserine. 
VAR_SEQ   1    13        Missing (in isoform 3). VSP_019579
VAR_SEQ   1     7        MKDSENK -> MSLLGSYRKKTSNDGYESLQLVDSNGDLSAGSGGVGGKQR VNAGAAARSPARQPPDRASTMDSS (in isoform 2). VSP_019580
VAR_SEQ   456   913        Missing (in isoform 3). VSP_019581
VARIANT   671   671  1     S -> N (in dbSNP:rs4915691 [NCBI]). VAR_026908 
CONFLICT   425   425        F -> S (in Ref. 3; AAH51722). 
Sequence information
Length: 913 AA [This is the length of the unprocessed precursor] Molecular weight: 99997 Da [This is the MW of the unprocessed precursor] CRC64: 7B7187AAC8ADF2E4 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKDSENKGAS SPDMEPSYGG GLFDMVKGGA GRLFSNLKDN LKDTLKDTSS RVIQSVTSYT 

        70         80         90        100        110        120 
KGDLDFTYVT SRIIVMSFPL DNVDIGFRNQ VDDIRSFLDS RHLDHYTVYN LSPKSYRTAK 

       130        140        150        160        170        180 
FHSRVSECSW PIRQAPSLHN LFAVCRNMYN WLLQNPKNVC VVHCLDGRAA SSILVGAMFI 

       190        200        210        220        230        240 
FCNLYSTPGP AIRLLYAKRP GIGLSPSHRR YLGYMCDLLA DKPYRPHFKP LTIKSITVSP 

       250        260        270        280        290        300 
IPFFNKQRNG CRPYCDVLIG ETKIYSTCTD FERMKEYRVQ DGKIFIPLNI TVQGDVVVSM 

       310        320        330        340        350        360 
YHLRSTIGSR LQAKVTNTQI FQLQFHTGFI PLDTTVLKFT KPELDACDVP EKYPQLFQVT 

       370        380        390        400        410        420 
LDVELQPHDK VIDLTPPWEH YCTKDVNPSI LFSSHQEHQD TLALGGQAPI DIPPDNPRHY 

       430        440        450        460        470        480 
GQSGFFASLC WQDQKSEKSF CEEDHAALVN QESEQSDDEL LTLSSPHGNA NGDKPHGVKK 

       490        500        510        520        530        540 
PSKKQQEPAA PPPPEDVDLL GLEGSAMSNS FSPPAAPPTN SELLSDLFGG GGAAGPTQAG 

       550        560        570        580        590        600 
QSGVEDVFHP SGPASTQSTP RRSATSTSAS PTLRVGEGAT FDPFGAPSKP SGQDLLGSFL 

       610        620        630        640        650        660 
NTSSASSDPF LQPTRSPSPT VHASSTPAVN IQPDVSGGWD WHAKPGGFGM GSKSAATSPT 

       670        680        690        700        710        720 
GSSHGTPTHQ SKPQTLDPFA DLGTLGSSSF ASKPTTPTGL GGGFPPLSSP QKASPQPMGG 

       730        740        750        760        770        780 
GWQQGGAYNW QQPQPKPQPS MPHSSPQNRP NYNVSFSAMP GGQNERGKGS SNLEGKQKAA 

       790        800        810        820        830        840 
DFEDLLSGQG FNAHKDKKGP RTIAEMRKEE MAKEMDPEKL KILEWIEGKE RNIRALLSTM 

       850        860        870        880        890        900 
HTVLWAGETK WKPVGMADLV TPEQVKKVYR KAVLVVHPDK ATGQPYEQYA KMIFMELNDA 

       910 
WSEFENQGQK PLY 

O75061 in FASTA format

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