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UniProtKB/Swiss-Prot entry O74833


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DNL4_SCHPO
Primary accession number O74833
Secondary accession numbers None
Integrated into Swiss-Prot on February 7, 2006
Sequence was last modified on May 1, 2000 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 45)
Name and origin of the protein
Protein name DNA ligase 4
Synonyms EC 6.5.1.1
DNA ligase IV
Polydeoxyribonucleotide synthase [ATP] 4
Gene name
Name: lig4
ORFNames: SPCC1183.05c
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
FUNCTION.
PubMed=11029034 [NCBI, ExPASy, EBI, Israel, Japan]
Baumann P., Cech T.R.;
"Protection of telomeres by the Ku protein in fission yeast.";
Mol. Biol. Cell 11:3265-3275(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CU329672; CAA21085.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T40845; T40845.
RefSeq NP_587888.1; -.
3D structure databases
ModBase O74833.
Organism-specific databases
GeneDB_Spombe SPCC1183.05c; -.
Gene expression databases
ArrayExpress O74833; -.
Ontologies
GO
GO:0032807; Cellular component: DNA ligase IV complex (traceable author statement from GeneDB_SPombe).
GO:0005524; Molecular function: ATP binding (inferred by curator from GeneDB_SPombe).
GO:0006303; Biological process: double-strand break repair via nonhomologous end joining (inferred from mutant phenotype from GeneDB_SPombe).
QuickGo view.
Family and domain databases
InterPro IPR001357; BRCT.
IPR000977; DNA_ligase.
IPR012309; DNA_ligase_A_C.
IPR012310; DNA_ligase_A_M.
IPR016059; DNA_ligase_CS.
IPR012340; NA-bd_OB-fold.
Graphical view of domain structure.
Gene3D G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
Pfam PF00533; BRCT; 1.
PF04679; DNA_ligase_A_C; 1.
PF01068; DNA_ligase_A_M; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00574; dnl1; 1.
PROSITE PS50172; BRCT; 1.
PS00697; DNA_LIGASE_A1; 1.
PS00333; DNA_LIGASE_A2; FALSE_NEG.
PS50160; DNA_LIGASE_A3; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS O74833.
Genome annotation databases
GeneID 2539042; -.
KEGG spo:SPCC1183.05c; -.
NMPDR fig|4896.1.peg.226; -.
Other
ProtoNet O74833.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding; Nucleus.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   923  923     DNA ligase 4. PRO_0000059581
DOMAIN   674   767  94     BRCT. 
ACT_SITE   295   295        N6-AMP-lysine intermediate (By similarity). 
Sequence information
Length: 923 AA [This is the length of the unprocessed precursor] Molecular weight: 107259 Da [This is the MW of the unprocessed precursor] CRC64: 6ED79683AB57DCE0 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDEAKETVFT KPQNHSSTLE FYDFVTTLLE PLSRIGKTRK SKTSNLDPYE LKRKILLDYF 

        70         80         90        100        110        120 
NKWRQHVGPD LYPLLRLSNL IFLDRERGSY GFKEFGLGKL FIRAMHLSPT SEDAKSLKNW 

       130        140        150        160        170        180 
RGSESKHTGD FSTMLQDILQ RRAYRTFPGA FTVGDVNALL DQLADASSEY VLNFLPYLTL 

       190        200        210        220        230        240 
IRDTRVNILE QFYRSLSPLE LRWLIPILLK VRKYGTSEKF ILSVFHPDAA RLYRLCSSLK 

       250        260        270        280        290        300 
RICWELYDPS RSLDETETDV EVFSCFQPQL ANFKKKDLHQ TLEAMGNKPF WIEEKLDGER 

       310        320        330        340        350        360 
IQLHMSSGKF QFYSRNARSY TYAYGSSYFD EQSRLTQYII GAFDKRISQI ILDGEMVTWD 

       370        380        390        400        410        420 
PVLETVIPYG SLRSIFEDSS SHSSYSPYYV VFDILYLNGK SLVKYSLESR RRILEKVIVR 

       430        440        450        460        470        480 
ESHRMSILPY KVGSTIEDIE AELRNVIQEG SEGLVIKKPS GSYHLGERMD DWIKVKPYYL 

       490        500        510        520        530        540 
QGFGEDLDCL ILGGYFGRGK QSGKINSFLC GLRMDYTPKD HSEKFQSFVR VGGGFTYFDR 

       550        560        570        580        590        600 
DIIRKETEGK WLPWSSDALE YMELAGTKQD FEKPDMWIHP KDSLVLQIKA AEVVVSNRFK 

       610        620        630        640        650        660 
TNYTLRFPRL EKVRLDRSWK DALTINEFFT LKNAVEKQDN VSFHVNKKRK VSQKREKQKK 

       670        680        690        700        710        720 
FLYDEPTFKK EASPHSDVLK NLHFVVLPPT ELHETKAGLQ QIIIENGGLI HQGVGNFGKE 

       730        740        750        760        770        780 
RLFLVADRVS TRVSIERSKN MCTIIRSQWV MDSVNNQRLM PQWSYLLFSK DEKYSWKTAL 

       790        800        810        820        830        840 
ESLSAKSLSN LLVELKQLDL SKEYSKISDD TSILNLTISK EEASFVGAFP FLKFTVFLDL 

       850        860        870        880        890        900 
KGIENSELYD VRMGQYRLTK CILLWNGATI EKDISSKKLT HVVMFVEDST RLEQLTKACE 

       910        920 
LTQHRKFTQP SYFQRYGGSF CIP 

O74833 in FASTA format

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View entry in raw text format (no links)
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