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UniProtKB/Swiss-Prot entry O74201


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name UBC2_CANAL
Primary accession number O74201
Secondary accession number Q5A0A0
Integrated into Swiss-Prot on July 15, 1999
Sequence was last modified on November 1, 1998 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 50)
Name and origin of the protein
Protein name Ubiquitin-conjugating enzyme E2 2
Synonyms EC 6.3.2.19
Ubiquitin-protein ligase UBC2
Ubiquitin carrier protein UBC2
Radiation sensitivity protein 6
Gene name
Name: UBC2
Synonyms: RAD6
ORFNames: CaO19.7195
From
Candida albicans (Yeast) [TaxID: 5476] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales; Candida.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=3153A;
Leng P., Brown A.J.P.;
"Molecular cloning and characterisation of CaRAD6 gene from Candida albicans.";
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
STRAIN=3153A;
PubMed=10712706 [NCBI, ExPASy, EBI, Israel, Japan]
Leng P., Sudbery P.E., Brown A.J.P.;
"Rad6p represses yeast-hypha morphogenesis in the human fungal pathogen Candida albicans.";
Mol. Microbiol. 35:1264-1275(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=SC5314;
DOI=10.1073/pnas.0401648101; PubMed=15123810 [NCBI, ExPASy, EBI, Israel, Japan]
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.;
"The diploid genome sequence of Candida albicans.";
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF036707; AAC24765.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF118145; AAD45241.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AACQ01000089; EAK96213.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_715243.1; -.
3D structure databases
HSSP P06104; 1AYZ. [HSSP ENTRY / PDB]
SMR O74201; 2-154.
ModBase O74201.
Organism-specific databases
CGD CAL0003164; RAD6.
Family and domain databases
InterPro IPR016135; UBQ-conjugat/RWD-like.
IPR000608; UBQ-conjugat_E2.
Graphical view of domain structure.
Gene3D G3DSA:3.10.110.10; UBQ-conjugat_E2; 1.
PANTHER PTHR11621; UBQ-conjugat_E2; 1.
Pfam PF00179; UQ_con; 1.
Pfam graphical view of domain structure.
ProDom PD000461; UBQ_conjugat; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00212; UBCc; 1.
SMART graphical view of domain structure.
PROSITE PS00183; UBIQUITIN_CONJUGAT_1; 1.
PS50127; UBIQUITIN_CONJUGAT_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS O74201.
Genome annotation databases
GeneID 3643143; -.
KEGG cal:CaO19.7195; -.
Other
ProtoNet O74201.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Chromatin regulator; Cytoplasm; DNA damage; DNA repair; Ligase; Nucleus; Sporulation; Transcription; Transcription regulation; Ubl conjugation pathway.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   179  179     Ubiquitin-conjugating enzyme E2 2. PRO_0000082528
REGION   151   179  29     Acidic tail. 
ACT_SITE   88    88        Glycyl thioester intermediate (By similarity). 
Sequence information
Length: 179 AA [This is the length of the unprocessed precursor] Molecular weight: 20576 Da [This is the MW of the unprocessed precursor] CRC64: 24A081B5F8E4D316 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSTPARRRLM RDFKRMQQDP PSGVSASPLP DNVMKWNAVI IGPSDTPFED GTFRLLLSFD 

        70         80         90        100        110        120 
EQYPNKPPQV KFISEMFHPN VYASGELCLD ILQNRWSPTY DVSSILTSVQ SLLNDPNISS 

       130        140        150        160        170 
PANVEAANLY KDHRSLYVKR VRETVENSWN DDDDEEEEEE DEDEAEDEDD DDDDNIDED 

O74201 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

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