[1]	NUCLEOTIDE SEQUENCE [MRNA]. Hyndman D.J., Flynn T.G.; "Partial sequence of Chinese hamster aldehyde reductase."; Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the NADPH-dependent reduction of a variety of aldehydes to their corresponding alcohols (By similarity).
CATALYTIC ACTIVITY: An alcohol + NADP⁺ = an aldehyde + NADPH.
SUBUNIT: Monomer (By similarity).
SIMILARITY: Belongs to the aldo/keto reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF060820; AAC15760.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P14550; 2ALR. [HSSP ENTRY / PDB]

SMR

O70473; 1-228.

ModBase

O70473.

Family and domain databases

InterPro

IPR001395; Aldo/ket_red.
Graphical view of domain structure.

Gene3D

G3DSA:3.20.20.100; Aldo/ket_red; 1.

PANTHER

PTHR11732; Aldo/ket_red; 1.

Pfam

PF00248; Aldo_ket_red; 1.
Pfam graphical view of domain structure.

PRINTS

PR00069; ALDKETRDTASE.

ProDom

PD000288; Aldo/ket_red; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00798; ALDOKETO_REDUCTASE_1; 1.
PS00062; ALDOKETO_REDUCTASE_2; 1.

BLOCKS

O70473.

Phylogenomic databases

HOVERGEN

O70473; -.

Other

ProtoNet

O70473.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 >228`	`>228`	`Alcohol dehydrogenase [NADP+].`	`PRO_0000124616`
`NP_BIND`	`196 228`	`33`	`NADP (By similarity).`
`ACT_SITE`	`35 35`		`Proton donor (By similarity).`
`BINDING`	`98 98`		`Substrate (By similarity).`
`SITE`	`65 65`	`1`	`Lowers pKa of active site Tyr (By similarity).`
`NON_TER`	`1 1`
`NON_TER`	`228 228`

Sequence information

Length: 228 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 25450 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 90C5625FD810DA93 [This is a checksum on the sequence]

        10         20         30         40         50         60 
LIGLGTWKSN PGQVKAAIKY ALSVGYRHID CAAVYGNEIE IGEALKENVG PGKAVPREEL 

        70         80         90        100        110        120 
FVTSKLWNTK HHPEDVEAAL RKTLADLQLE YLDLYLMHWP YAFERGDNPF PKNDDGTIRY 

       130        140        150        160        170        180 
DSTHYKETWK ALEALVAKGL VKALGLSNFN SRQIDDILSV ASVRPAVLQV ECHPYLAQNE 

       190        200        210        220 
LIAHCQARGL EVTAYSPLGS SDRAWRHPDE PVLLEEPVVL ALAEKHGR

O70473 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools