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UniProtKB/Swiss-Prot entry O68282

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G6PD_PSEAE
Primary accession number O68282
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 56)
Name and origin of the protein
Protein name Glucose-6-phosphate 1-dehydrogenase
Synonyms G6PD
EC 1.1.1.49
Gene name
Name: zwf
OrderedLocusNames: PA3183
From
Pseudomonas aeruginosa [TaxID: 287] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
PubMed=9537370 [NCBI, ExPASy, EBI, Israel, Japan]
Ma J.-F., Hager P.W., Howell M.L., Phibbs P.V. Jr., Hassett D.J.;
"Cloning and characterization of the Pseudomonas aeruginosa zwf gene encoding glucose-6-phosphate dehydrogenase, an enzyme important in resistance to methyl viologen (paraquat).";
J. Bacteriol. 180:1741-1749(1998).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
DOI=10.1038/35023079; PubMed=10984043 [NCBI, ExPASy, EBI, Israel, Japan]
Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.";
Nature 406:959-964(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF029673; AAC38311.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE004091; AAG06571.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A83248; A83248.
RefSeq NP_251873.1; -.
3D structure databases
HSSP P11413; 1QKI. [HSSP ENTRY / PDB]
ModBase O68282.
Enzyme and pathway databases
BioCyc PAER208964:PA3183-MON; -.
Organism-specific databases
PseudoCAP PA3183; -.
Family and domain databases
InterPro IPR001282; Glc-6-P_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23429; G6PDH; 1.
Pfam PF02781; G6PD_C; 1.
PF00479; G6PD_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000110; G6PD; 1.
PRINTS PR00079; G6PDHDRGNASE.
ProDom PD001129; G6PD; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00871; zwf; 1.
PROSITE PS00069; G6P_DEHYDROGENASE; 1.
BLOCKS O68282.
Genome annotation databases
GeneID 882681; -.
GenomeReviews AE004091_GR; PA3183.
KEGG pae:PA3183; -.
Phylogenomic databases
HOGENOM O68282; -.
Genome annotation databases
CMR O68282; PA3183.
Other
ProtoNet O68282.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Carbohydrate metabolism; Complete proteome; Glucose metabolism; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   489  489     Glucose-6-phosphate 1-dehydrogenase. PRO_0000068131
ACT_SITE   237   237        Proton acceptor (By similarity). 
BINDING   17    17        NADP (By similarity). 
BINDING   49    49        NADP (By similarity). 
BINDING   175   175        Substrate (By similarity). 
BINDING   179   179        Substrate (By similarity). 
BINDING   342   342        Substrate (By similarity). 
Sequence information
Length: 489 AA [This is the length of the unprocessed precursor] Molecular weight: 55620 Da [This is the MW of the unprocessed precursor] CRC64: 755849EB33BF9486 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPDVRVLPCT LALFGALGDL ALRKLFPALY QLDRENLLHR DTRVLALARD EGAPAEHLAT 

        70         80         90        100        110        120 
LEQRLRLAVP AKEWDDVVWQ RFRERLDYLS MDFLDPQAYV GLREAVDDEL PLVAYFATPA 

       130        140        150        160        170        180 
SVFGGICENL AAAGLAERTR VVLEKPIGHD LESSREVNEA VARFFPESRI YRIDHYLGKE 

       190        200        210        220        230        240 
TVQNLIALRF ANSLFETQWN QNHISHVEIT VAEKVGIEGR WGYFDQAGQL RDMVQNHLLQ 

       250        260        270        280        290        300 
LLCLIAMDPP SDLSADSIRD EKVKVLRALE PIPAEQLASR VVRGQYTAGF SDGKAVPGYL 

       310        320        330        340        350        360 
EEEHANRDSD AETFVALRVD IRNWRWSGVP FYLRTGKRMP QKLSQIVIHF KEPPHYIFAP 

       370        380        390        400        410        420 
EQRSLISNRL IIRLQPDEGI SLQVMTKDQG LGKGMQLRTG PLQLSFSETY HAARIPDAYE 

       430        440        450        460        470        480 
RLLLEVTQGN QYLFVRKDEV EFAWKWCDQL IAGWERLSEA PKPYPAGSWG PVASVALVAR 


DGRSWYGDF
O68282 in FASTA format

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