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UniProtKB/Swiss-Prot entry O67480

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH_AQUAE
Primary accession number O67480
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 52)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP]
Synonyms IDH
EC 1.1.1.42
Oxalosuccinate decarboxylase
NADP(+)-specific ICDH
IDP
Gene name
Name: icd
OrderedLocusNames: aq_1512
From
Aquifex aeolicus [TaxID: 63363] [HAMAP proteome]
Taxonomy Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=VF5;
DOI=10.1038/32831; PubMed=9537320 [NCBI, ExPASy, EBI, Israel, Japan]
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
Nature 392:353-358(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000657; AAC07444.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR F70431; F70431.
RefSeq NP_214045.1; -.
3D structure databases
HSSP P08200; 1ISO. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
ModBase O67480.
Enzyme and pathway databases
BioCyc AAEO224324:AQ_1512-MON; -.
Family and domain databases
InterPro IPR004439; IsoCit_DHase_NADP_prok.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF1; NADP_IDH_prok; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS O67480.
Genome annotation databases
GeneID 1193103; -.
GenomeReviews AE000657_GR; aq_1512.
KEGG aae:aq_1512; -.
NMPDR fig|224324.1.peg.1060; -.
Phylogenomic databases
HOGENOM O67480; -.
Genome annotation databases
CMR O67480; aq_1512.
Other
ProtoNet O67480.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   426  426     Isocitrate dehydrogenase [NADP]. PRO_0000083548
METAL   312   312        Magnesium or manganese (By similarity). 
BINDING   123   123        Substrate (By similarity). 
BINDING   125   125        Substrate (By similarity). 
BINDING   129   129        Substrate (By similarity). 
BINDING   139   139        Substrate (By similarity). 
BINDING   162   162        Substrate (By similarity). 
SITE   169   169  1     Critical for catalysis (By similarity). 
SITE   239   239  1     Critical for catalysis (By similarity). 
MOD_RES   123   123        Phosphoserine (By similarity). 
Sequence information
Length: 426 AA [This is the length of the unprocessed precursor] Molecular weight: 46925 Da [This is the MW of the unprocessed precursor] CRC64: 06E47E36D844432A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNKTTFENVY YWEGKAQIPQ EGQFIKLKED KTLEVPDNPI IPFIEGDGIG PEITQAMLLI 

        70         80         90        100        110        120 
INTAVEKTYN GSKKIYWVEL LAGDKAEEKT GERLPQETLD VLKESIVGIK GPLGTPVGKG 

       130        140        150        160        170        180 
VRSINSALRR AFDYYSAVRP VYWMGQATPI PNPERVDLVV FRENTDDVYA GVEFFAGTPE 

       190        200        210        220        230        240 
AKKVREFLIK EMGAKEEGFP EDVGITVKPM SEFKTKRHVR KALRYALENN KKNVAVIGKG 

       250        260        270        280        290        300 
NIMKATEGAF INWAFEVAEE PEFKGKVVTD PEAEPGEGQV KLTKVITDQM LMQLVLKPEA 

       310        320        330        340        350        360 
WDVIIAQNLN GDYVSDLAAS LIGGPGFVPS GNIGDGYALF ESTHGTAWDI AGKGIANPLS 

       370        380        390        400        410        420 
LTLSGAMMLE YIGWKEAAQK VYDAVRRTLA EHIGTPDIAS GFQKQGIEAK AVGTMEFAEE 


ISKRIE
O67480 in FASTA format

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