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UniProtKB/Swiss-Prot entry O66806

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DDL_AQUAE
Primary accession number O66806
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 61)
Name and origin of the protein
Protein name D-alanine--D-alanine ligase
Synonyms EC 6.3.2.4
D-alanylalanine synthetase
D-Ala-D-Ala ligase
Gene name
Name: ddl
Synonyms: ddlA
OrderedLocusNames: aq_521
From
Aquifex aeolicus [TaxID: 63363] [HAMAP proteome]
Taxonomy Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=VF5;
DOI=10.1038/32831; PubMed=9537320 [NCBI, ExPASy, EBI, Israel, Japan]
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
Nature 392:353-358(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000657; AAC06765.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B70347; B70347.
RefSeq NP_213366.1; -.
3D structure databases
HSSP P07862; 1IOV. [HSSP ENTRY / PDB]
ModBase O66806.
Enzyme and pathway databases
BioCyc AAEO224324:AQ_521-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0008716; Molecular function: D-alanine-D-alanine ligase activity (inferred from electronic annotation from HAMAP).
GO:0009252; Biological process: peptidoglycan biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00047; -; 1.
PBIL [Tree]
InterPro IPR011761; ATP-grasp.
IPR013816; ATP_grasp_subdomain_2.
IPR000291; D-Ala_lig_Van_CS.
IPR005905; D_ala_D_ala.
IPR011095; Dala_Dala_lig_C.
IPR011127; Dala_Dala_lig_N.
IPR013817; Pre-ATP_grasp.
Graphical view of domain structure.
Gene3D G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
G3DSA:3.40.50.20; Pre-ATP_grasp; 1.
Pfam PF07478; Dala_Dala_lig_C; 1.
PF01820; Dala_Dala_lig_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01205; D_ala_D_alaTIGR; 1.
PROSITE PS50975; ATP_GRASP; 1.
PS00843; DALA_DALA_LIGASE_1; 1.
PS00844; DALA_DALA_LIGASE_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS O66806.
Genome annotation databases
GeneID 1193224; -.
GenomeReviews AE000657_GR; aq_521.
KEGG aae:aq_521; -.
NMPDR fig|224324.1.peg.381; -.
Phylogenomic databases
HOGENOM O66806; -.
Genome annotation databases
CMR O66806; aq_521.
Other
ProtoNet O66806.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Ligase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Peptidoglycan synthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   291  291     D-alanine--D-alanine ligase. PRO_0000177780
DOMAIN   99   291  193     ATP-grasp. 
NP_BIND   125   179  55     ATP (By similarity). 
METAL   245   245        Magnesium or manganese 1 (By similarity). 
METAL   258   258        Magnesium or manganese 1 (By similarity). 
METAL   258   258        Magnesium or manganese 2 (By similarity). 
METAL   260   260        Magnesium or manganese 2 (By similarity). 
Sequence information
Length: 291 AA [This is the length of the unprocessed precursor] Molecular weight: 32797 Da [This is the MW of the unprocessed precursor] CRC64: B0A892F15539C143 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRVVVLMGGR SSEREISLKT GKAVAKALRE LGHEVYELDL DKELPCKLLE IKPDKVFIAL 

        70         80         90        100        110        120 
HGRYGEDGTV QGLLEILDIP YTGSDTIASA VSIDKDFTKR IVKSLGINTP DWETFISEGD 

       130        140        150        160        170        180 
VLNTEWNKFP AVVKPVREGS SVGLKIVESL EELKEYALDL LKKTERVMVE EFVEGRDMTV 

       190        200        210        220        230        240 
GILKGEALPV VEIIPKKGVY DYECKYTKGM SEYRILKDEK LSKKLQEISL KISKFLSLKD 

       250        260        270        280        290 
FARIDFRVTK EGKIFFLEVN TIPGMTELSL LPMAAKEKGM DFKKLISIII T
O66806 in FASTA format

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