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UniProtKB/Swiss-Prot entry O60241


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name BAI2_HUMAN
Primary accession number O60241
Secondary accession numbers B9EGK9 Q5T6K0 Q8NGW8 Q96GZ9
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on May 5, 2009 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 89)
Name and origin of the protein
Protein name Brain-specific angiogenesis inhibitor 2 [Precursor]
Synonyms None
Gene name
Name: BAI2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=Fetal brain;
PubMed=9533023 [NCBI, ExPASy, EBI, Israel, Japan]
Shiratsuchi T., Nishimori H., Ichise H., Nakamura Y., Tokino T.;
"Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1).";
Cytogenet. Cell Genet. 79:103-108(1997).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes.";
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1293-1585 (ISOFORM 1).
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB005298; BAA25362.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB065648; BAC05874.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL354919; CAI16890.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC114488; CAI16890.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC009035; AAH09035.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC136533; AAI36534.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00297188; -.
PIR T00027; T00027.
RefSeq NP_001694.2; -.
UniGene Hs.524138
3D structure databases
HSSP P07996; 1LSL. [HSSP ENTRY / PDB]
ModBase O60241.
Protein family/group databases
GPCRDB O60241; BAI2_HUMAN.
PTM databases
PhosphoSite O60241; -.
Organism-specific databases
GeneCards GC01M032000; -.
H-InvDB HIX0023509; -.
HGNC HGNC:944; BAI2.
GenAtlas BAI2.
MIM 602683; gene. [NCBI / EBI]
PharmGKB PA25248; -.
Gene expression databases
ArrayExpress O60241; -.
Bgee O60241; -.
CleanEx HS_BAI2; -.
GermOnline ENSG00000121753; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (traceable author statement from GDB).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016527; Molecular function: brain-specific angiogenesis inhibitor activity (traceable author statement from GDB).
GO:0007218; Biological process: neuropeptide signaling pathway (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR017981; GPCR_2-like.
IPR008077; GPCR_2_brain-spec_angio_inhib.
IPR001879; GPCR_2_extracellular.
IPR000832; GPCR_2_secretin-like.
IPR017983; GPCR_2_secretin-like_CS.
IPR000203; PKD_cys_rich.
IPR000884; Thrombospondin_1_rpt.
Graphical view of domain structure.
Pfam PF00002; 7tm_2; 1.
PF01825; GPS; 1.
PF02793; HRM; 1.
PF00090; TSP_1; 4.
Pfam graphical view of domain structure.
PRINTS PR01694; BAIPRECURSOR.
PR00249; GPCRSECRETIN.
SMART SM00303; GPS; 1.
SM00008; HormR; 1.
SM00209; TSP1; 4.
SMART graphical view of domain structure.
PROSITE PS00649; G_PROTEIN_RECEP_F2_1; FALSE_NEG.
PS00650; G_PROTEIN_RECEP_F2_2; FALSE_NEG.
PS50227; G_PROTEIN_RECEP_F2_3; 1.
PS50261; G_PROTEIN_RECEP_F2_4; 1.
PS50221; GPS; 1.
PS50092; TSP1; 4.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
Ensembl ENSG00000121753; Homo sapiens. [Contig view]
GeneID 576; -.
KEGG hsa:576; -.
Phylogenomic databases
HOVERGEN O60241; -.
Other
NextBio 2351; -.
SOURCE BAI2; Homo sapiens.
GPCRDB-Snakes O60241.
ProtoNet O60241.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein; Receptor; Repeat; Signal; Transducer; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
SIGNAL   1     32  32     Potential. 
CHAIN   33   1585  1553     Brain-specific angiogenesis inhibitor 2. PRO_0000012864
TOPO_DOM   33    936  904     Extracellular (Potential). 
TRANSMEM   937    957  21     1 (Potential). 
TOPO_DOM   958    965  8     Cytoplasmic (Potential). 
TRANSMEM   966    986  21     2 (Potential). 
TOPO_DOM   987    994  8     Extracellular (Potential). 
TRANSMEM   995   1015  21     3 (Potential). 
TOPO_DOM   1016   1036  21     Cytoplasmic (Potential). 
TRANSMEM   1037   1057  21     4 (Potential). 
TOPO_DOM   1058   1078  21     Extracellular (Potential). 
TRANSMEM   1079   1099  21     5 (Potential). 
TOPO_DOM   1100   1121  22     Cytoplasmic (Potential). 
TRANSMEM   1122   1142  21     6 (Potential). 
TOPO_DOM   1143   1153  11     Extracellular (Potential). 
TRANSMEM   1154   1174  21     7 (Potential). 
TOPO_DOM   1175   1584  410     Cytoplasmic (Potential). 
DOMAIN   309    362  54     TSP type-1 1. 
DOMAIN   364    417  54     TSP type-1 2. 
DOMAIN   419    472  54     TSP type-1 3. 
DOMAIN   475    528  54     TSP type-1 4. 
DOMAIN   871    923  53     GPS. 
COMPBIAS   129    134  6     Poly-Glu. 
COMPBIAS   189    192  4     Poly-Asn. 
COMPBIAS   234    237  4     Poly-Thr. 
COMPBIAS   1315   1318  4     Poly-Pro. 
COMPBIAS   1364   1370  7     Poly-Gly. 
COMPBIAS   1425   1430  6     Poly-Pro. 
MOD_RES   1351   1351        Phosphotyrosine (By similarity). 
CARBOHYD   106    106        N-linked (GlcNAc...) (Potential). 
CARBOHYD   191    191        N-linked (GlcNAc...) (Potential). 
CARBOHYD   192    192        N-linked (GlcNAc...) (Potential). 
CARBOHYD   356    356        N-linked (GlcNAc...) (Potential). 
CARBOHYD   437    437        N-linked (GlcNAc...) (Potential). 
CARBOHYD   560    560        N-linked (GlcNAc...) (Potential). 
CARBOHYD   645    645        N-linked (GlcNAc...) (Potential). 
CARBOHYD   867    867        N-linked (GlcNAc...) (Potential). 
DISULFID   321    355        By similarity. 
DISULFID   325    361        By similarity. 
DISULFID   336    345        By similarity. 
DISULFID   376    411        By similarity. 
DISULFID   380    416        By similarity. 
DISULFID   391    401        By similarity. 
DISULFID   431    466        By similarity. 
DISULFID   435    471        By similarity. 
DISULFID   446    456        By similarity. 
DISULFID   487    522        By similarity. 
DISULFID   491    527        By similarity. 
DISULFID   502    512        By similarity. 
VAR_SEQ   1     12        Missing (in isoform 3). VSP_037045
VAR_SEQ   1119   1151        Missing (in isoform 4). VSP_037046
VAR_SEQ   1473   1473        Missing (in isoform 2 and isoform 4). VSP_037047
CONFLICT   325    325        C -> R (in Ref. 4; AAI36534). 
Sequence information
Length: 1585 AA [This is the length of the unprocessed precursor] Molecular weight: 172656 Da [This is the MW of the unprocessed precursor] CRC64: 56D253AE0AB1552D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MENTGWMGKG HRMTPACPLL LSVILSLRLA TAFDPAPSAC SALASGVLYG AFSLQDLFPT 

        70         80         90        100        110        120 
IASGCSWTLE NPDPTKYSLY LRFNRQEQVC AHFAPRLLPL DHYLVNFTCL RPSPEEAVAQ 

       130        140        150        160        170        180 
AESEVGRPEE EEAEAAAGLE LCSGSGPFTF LHFDKNFVQL CLSAEPSEAP RLLAPAALAF 

       190        200        210        220        230        240 
RFVEVLLINN NNSSQFTCGV LCRWSEECGR AAGRACGFAQ PGCSCPGEAG AGSTTTTSPG 

       250        260        270        280        290        300 
PPAAHTLSNA LVPGGPAPPA EADLHSGSSN DLFTTEMRYG EEPEEEPKVK TQWPRSADEP 

       310        320        330        340        350        360 
GLYMAQTGDP AAEEWSPWSV CSLTCGQGLQ VRTRSCVSSP YGTLCSGPLR ETRPCNNSAT 

       370        380        390        400        410        420 
CPVHGVWEEW GSWSLCSRSC GRGSRSRMRT CVPPQHGGKA CEGPELQTKL CSMAACPVEG 

       430        440        450        460        470        480 
QWLEWGPWGP CSTSCANGTQ QRSRKCSVAG PAWATCTGAL TDTRECSNLE CPATDSKWGP 

       490        500        510        520        530        540 
WNAWSLCSKT CDTGWQRRFR MCQATGTQGY PCEGTGEEVK PCSEKRCPAF HEMCRDEYVM 

       550        560        570        580        590        600 
LMTWKKAAAG EIIYNKCPPN ASGSASRRCL LSAQGVAYWG LPSFARCISH EYRYLYLSLR 

       610        620        630        640        650        660 
EHLAKGQRML AGEGMSQVVR SLQELLARRT YYSGDLLFSV DILRNVTDTF KRATYVPSAD 

       670        680        690        700        710        720 
DVQRFFQVVS FMVDAENKEK WDDAQQVSPG SVHLLRVVED FIHLVGDALK AFQSSLIVTD 

       730        740        750        760        770        780 
NLVISIQREP VSAVSSDITF PMRGRRGMKD WVRHSEDRLF LPKEVLSLSS PGKPATSGAA 

       790        800        810        820        830        840 
GSPGRGRGPG TVPPGPGHSH QRLLPADPDE SSYFVIGAVL YRTLGLILPP PRPPLAVTSR 

       850        860        870        880        890        900 
VMTVTVRPPT QPPAEPLITV ELSYIINGTT DPHCASWDYS RADASSGDWD TENCQTLETQ 

       910        920        930        940        950        960 
AAHTRCQCQH LSTFAVLAQP PKDLTLELAG SPSVPLVIGC AVSCMALLTL LAIYAAFWRF 

       970        980        990       1000       1010       1020 
IKSERSIILL NFCLSILASN ILILVGQSRV LSKGVCTMTA AFLHFFFLSS FCWVLTEAWQ 

      1030       1040       1050       1060       1070       1080 
SYLAVIGRMR TRLVRKRFLC LGWGLPALVV AVSVGFTRTK GYGTSSYCWL SLEGGLLYAF 

      1090       1100       1110       1120       1130       1140 
VGPAAVIVLV NMLIGIIVFN KLMARDGISD KSKKQRAGSE RCPWASLLLP CSACGAVPSP 

      1150       1160       1170       1180       1190       1200 
LLSSASARNA MASLWSSCVV LPLLALTWMS AVLAMTDRRS VLFQALFAVF NSAQGFVITA 

      1210       1220       1230       1240       1250       1260 
VHCFLRREVQ DVVKCQMGVC RADESEDSPD SCKNGQLQIL SDFEKDVDLA CQTVLFKEVN 

      1270       1280       1290       1300       1310       1320 
TCNPSTITGT LSRLSLDEDE EPKSCLVGPE GSLSFSPLPG NILVPMAASP GLGEPPPPQE 

      1330       1340       1350       1360       1370       1380 
ANPVYMCGEG GLRQLDLTWL RPTEPGSEGD YMVLPRRTLS LQPGGGGGGG EDAPRARPEG 

      1390       1400       1410       1420       1430       1440 
TPRRAAKTVA HTEGYPSFLS VDHSGLGLGP AYGSLQNPYG MTFQPPPPTP SARQVPEPGE 

      1450       1460       1470       1480       1490       1500 
RSRTMPRTVP GSTMKMGSLE RKKLRYSDLD FEKVMHTRKR HSELYHELNQ KFHTFDRYRS 

      1510       1520       1530       1540       1550       1560 
QSTAKREKRW SVSSGGAAER SVCTDKPSPG ERPSLSQHRR HQSWSTFKSM TLGSLPPKPR 

      1570       1580 
ERLTLHRAAA WEPTEPPDGD FQTEV 

O60241 in FASTA format

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