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UniProtKB/Swiss-Prot entry O59666


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ATU2_SCHPO
Primary accession number O59666
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 57)
Name and origin of the protein
Protein name Copper-transporting ATPase ccc2
Synonyms EC 3.6.3.4
Cu(2+)-ATPase
Gene name
Name: ccc2
ORFNames: SPBC29A3.01
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
DOI=10.1038/nbt1222; PubMed=16823372 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.;
"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.";
Nat. Biotechnol. 24:841-847(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CU329671; CAA18378.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T40072; T40072.
RefSeq NP_595829.1; -.
3D structure databases
HSSP Q04656; 1KVJ. [HSSP ENTRY / PDB]
ModBase O59666.
Organism-specific databases
GeneDB_Spombe SPBC29A3.01; -.
Gene expression databases
ArrayExpress O59666; -.
Ontologies
GO
GO:0005794; Cellular component: Golgi apparatus (inferred from direct assay from GeneDB_SPombe).
GO:0005774; Cellular component: vacuolar membrane (inferred from direct assay from GeneDB_SPombe).
GO:0005524; Molecular function: ATP binding (inferred by curator from GeneDB_SPombe).
QuickGo view.
Family and domain databases
InterPro IPR006416; ATPase-IB_hvy.
IPR001757; ATPase_P.
IPR006403; ATPase_P_cat/Cu.
IPR001877; Cu_ATPase1.
IPR005834; Dehalogen-like_hydro.
IPR008250; E1-E2_ATPase_reg.
IPR006121; HeavyMe_transpt.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
Pfam PF00122; E1-E2_ATPase; 1.
PF00403; HMA; 1.
PF00702; Hydrolase; 1.
Pfam graphical view of domain structure.
PRINTS PR00119; CATATPASE.
PR00942; CUATPASEI.
TIGRFAMs TIGR01511; ATPase-IB1_Cu; 1.
TIGR01525; ATPase-IB_hvy; 1.
TIGR01494; ATPase_P-type; 2.
PROSITE PS00154; ATPASE_E1_E2; 1.
PS01047; HMA_1; 1.
PS50846; HMA_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS O59666.
Genome annotation databases
GeneID 2540525; -.
KEGG spo:SPBC29A3.01; -.
NMPDR fig|4896.1.peg.1695; -.
Other
ProtoNet O59666.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Copper; Copper transport; Golgi apparatus; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   904  904     Copper-transporting ATPase ccc2. PRO_0000314753
TOPO_DOM   1   172  172     Cytoplasmic (By similarity). 
TRANSMEM   173   193  21     Potential. 
TOPO_DOM   194   197  4     Lumenal, vesicle (By similarity). 
TRANSMEM   198   218  21     Potential. 
TOPO_DOM   219   246  28     Cytoplasmic (By similarity). 
TRANSMEM   247   267  21     Potential. 
TOPO_DOM   268   278  11     Lumenal, vesicle (By similarity). 
TRANSMEM   279   296  18     Potential. 
TOPO_DOM   297   431  135     Cytoplasmic (By similarity). 
TRANSMEM   432   452  21     Potential. 
TOPO_DOM   453   469  17     Lumenal, vesicle (By similarity). 
TRANSMEM   470   490  21     Potential. 
TOPO_DOM   491   805  315     Cytoplasmic (By similarity). 
TRANSMEM   806   826  21     Potential. 
TOPO_DOM   827   828  2     Lumenal, vesicle (By similarity). 
TRANSMEM   829   849  21     Potential. 
TOPO_DOM   850   904  55     Cytoplasmic (By similarity). 
DOMAIN   3    69  67     HMA. 
COMPBIAS   480   483  4     Poly-Val. 
COMPBIAS   645   648  4     Poly-Ser. 
ACT_SITE   529   529        4-aspartylphosphate intermediate (By similarity). 
METAL   13    13        Copper (By similarity). 
METAL   16    16        Copper (By similarity). 
METAL   742   742        Magnesium (By similarity). 
METAL   746   746        Magnesium (By similarity). 
Sequence information
Length: 904 AA [This is the length of the unprocessed precursor] Molecular weight: 97895 Da [This is the MW of the unprocessed precursor] CRC64: 546EE3C8AAECE146 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MYTTTLSVQG MTCTSCVASI QSMLEGVEGI EQFTISLLLE RAIAVHDPSI ISPDQIAEKI 

        70         80         90        100        110        120 
EDCGFDASVI SSTEGEHGVM ANYLLLSPMQ AEQWTKVHNH INELQGVLSV NCSSSPDAAI 

       130        140        150        160        170        180 
RVIYDSEITG PRSIMKEILS MGVKCTFQPV DSSTSRILSL QRGSQIRVWK IRFIISISFS 

       190        200        210        220        230        240 
LAVMFLPQIF DSCDSMRAAF LVPHYFGICA GHIISLVLSL PVQFGVGRVY YSAAYHALKR 

       250        260        270        280        290        300 
GTANMDVLVS LGSTVAFAAS IFFMILYSAR HADNPAPIFF DTADMLLTFV TLGRYLESKA 

       310        320        330        340        350        360 
KGSTSAALSQ LLSLAPSSAT IIEDNEQIEI LADLIERGDL ILVKPGEIIP VDGTVVEGSS 

       370        380        390        400        410        420 
YVDESSVSGE PVPVHKTIDD ELLSGTANGN GRLLVKATKS PRESQLAVIV DLVQRAQISH 

       430        440        450        460        470        480 
APIQQFADRV AGIFVPVIVA LSISTFTFWF LFTKYSSKYP SVFDDPMGKF AVCLKLTISV 

       490        500        510        520        530        540 
VVVACPCALG LSTPTAVMVG TGVGALNGII IKGGEILERL NQVDTVVFDK TGTLTVGKLS 

       550        560        570        580        590        600 
VTDISIVDNL EELLDIPKNI FWAFVKASES SSEHPIGKAI TEKASEFTDV SEIGIESFNA 

       610        620        630        640        650        660 
VPGEGVDVVL RWKERTFHAL LGNSLLLEHN NVSIPDDFDS KLKLSSSSGL TCVRIAIDGQ 

       670        680        690        700        710        720 
FVGFLGCMDQ VRPDSYQTVS ALKQLGKKVC LLTGDQKATA RRVAQGLEID FSDVYAEAVP 

       730        740        750        760        770        780 
SQKAEIIQKL KDQKHCVAMV GDGINDSPSL VLADVGIAPI NGSGIALESA DVILVRKGVL 

       790        800        810        820        830        840 
LDTAVSFDLS RVIVKRIKMN LVWACIYNFV MIPIAMGFFL PWGIYLNPMW ASAAMMFSSL 

       850        860        870        880        890        900 
SVLASSLLLR RWKKPKSLIF SEADDVETES STNSSVLQKV YTATRSIFGR NKSSNKYQPV 


ANEV 

O59666 in FASTA format

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