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UniProtKB/Swiss-Prot entry O58061

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PUR2_PYRHO
Primary accession number O58061
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 57)
Name and origin of the protein
Protein name Phosphoribosylamine--glycine ligase
Synonyms EC 6.3.4.13
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene name
Name: purD
OrderedLocusNames: PH0323
From
Pyrococcus horikoshii [TaxID: 53953] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Pyrococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=OT3;
DOI=10.1093/dnares/5.2.55; PubMed=9679194 [NCBI, ExPASy, EBI, Israel, Japan]
Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
DNA Res. 5:55-76(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000001; BAA29397.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR H71138; H71138.
RefSeq NP_142306.1; -.
3D structure databases
HSSP P15640; 1GSO. [HSSP ENTRY / PDB]
ModBase O58061.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030145; Molecular function: manganese ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004637; Molecular function: phosphoribosylamine-glycine ligase activity (inferred from electronic annotation from HAMAP).
GO:0009113; Biological process: purine base biosynthetic process (inferred from electronic annotation from InterPro).
GO:0006164; Biological process: purine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00138; -; 1.
PBIL [Tree]
InterPro IPR011761; ATP-grasp.
IPR013815; ATP_grasp_subdomain_1.
IPR013816; ATP_grasp_subdomain_2.
IPR000115; Gars.
IPR013817; Pre-ATP_grasp.
Graphical view of domain structure.
Gene3D G3DSA:3.30.1490.20; ATP_grasp_subdomain_1; 1.
G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
G3DSA:3.40.50.20; Pre-ATP_grasp; 1.
Pfam PF01071; GARS_A; 1.
PF02843; GARS_C; 1.
PF02844; GARS_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00877; purD; 1.
PROSITE PS50975; ATP_GRASP; 1.
PS00184; GARS; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
GeneID 1444205; -.
GenomeReviews BA000001_GR; PH0323.
KEGG pho:PH0323; -.
NMPDR fig|70601.1.peg.305; -.
Phylogenomic databases
HOGENOM O58061; -.
Genome annotation databases
CMR O58061; PH0323.
Other
ProtoNet O58061.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Ligase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Purine biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   438  438     Phosphoribosylamine--glycine ligase. PRO_0000151516
DOMAIN   108   316  209     ATP-grasp. 
NP_BIND   135   194  60     ATP (By similarity). 
METAL   274   274        Magnesium or manganese 1 (By similarity). 
METAL   286   286        Magnesium or manganese 1 (By similarity). 
METAL   286   286        Magnesium or manganese 2 (By similarity). 
METAL   288   288        Magnesium or manganese 2 (By similarity). 
Sequence information
Length: 438 AA [This is the length of the unprocessed precursor] Molecular weight: 48458 Da [This is the MW of the unprocessed precursor] CRC64: 396EED8AF69A7805 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKVLLVGGGG REHAIGEALV KGGAELYVVS NHRNPGLMRL AKDYGLAKET NVEDVIKFAR 

        70         80         90        100        110        120 
KWGIELAFIG PEAPLEAGIV NALEEEGIPA VGPTREAARL ETNKAWAREF MERNNIPGRK 

       130        140        150        160        170        180 
MFRIFDDVQE MRKWIDEYGK PVVVKPLGLT GGKGVKVVGY QLKDNEEAKE YAEHIIRKDG 

       190        200        210        220        230        240 
KVLIEERTDG VEFTLQVFTD GKKVIPMPLV QDYPHAYEGD VGPITGGMGS YSCSNHLLPF 

       250        260        270        280        290        300 
ITEGDFERAL KTLEETIEAM RKEGYPYKGI LYGQFMLSGE GPVLIEYNAR FGDPEAINVL 

       310        320        330        340        350        360 
AVLDDNLLEI AKGIVEGSLR KAKFLNKATV VKYIAPQGYP QDPIKGIRIE VDEEGIKNEG 

       370        380        390        400        410        420 
AKIIYAAVDE NLTLLGSRAL AIVGVADSLE EAERIAENGV SYVKGPIFYR KDVGTRESVE 

       430 
KRIEIMKKLG KEFEPNLC
O58061 in FASTA format

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