[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Forebrain; Kimura N., Kurosawa N., Kondo K., Tsukada Y.; "Molecular cloning of SPM2 from duckling brain: a putative brain specific steroid dehydrogenase and its induction by imprinting stimuli."; Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation (By similarity).
CATALYTIC ACTIVITY: Estradiol-17-beta + NAD(P)⁺ = estrone + NAD(P)H.
PATHWAY: Steroid metabolism; estrogen biosynthesis .
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).
TISSUE SPECIFICITY: Brain.
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB009304; BAA23765.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

O57314.

Ontologies

GO:0005789;	Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.

Family and domain databases

InterPro

IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR19410; ADH_short_C2; 1.

Pfam

PF00106; adh_short; 1.
Pfam graphical view of domain structure.

PRINTS

PR00081; GDHRDH.
PR00080; SDRFAMILY.

PROSITE

PS00061; ADH_SHORT; 1.

BLOCKS

O57314.

Phylogenomic databases

HOVERGEN

O57314; -.

Other

ProtoNet

O57314.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Endoplasmic reticulum; Lipid synthesis; Membrane; NADP; Oxidoreductase; Steroid biosynthesis; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 312`	`312`	`Estradiol 17-beta-dehydrogenase 12.`	`PRO_0000054577`
`TRANSMEM`	`33 53`	`21`	`Potential.`
`TRANSMEM`	`181 201`	`21`	`Potential.`
`TRANSMEM`	`274 294`	`21`	`Potential.`
`NP_BIND`	`48 77`	`30`	`NADP (By similarity).`
`ACT_SITE`	`201 201`		`Proton acceptor (By similarity).`
`BINDING`	`188 188`		`Substrate (By similarity).`

Sequence information

Length: 312 AA [This is the length of the unprocessed precursor]

Molecular weight: 33896 Da [This is the MW of the unprocessed precursor]

CRC64: 744D8F44491A9262 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLPAAGLLWW VGALGALYAA VRGALGLLGA LRVWGIGAGR AALGPGLGAW AVVTGATDGI 

        70         80         90        100        110        120 
GKAYAKELAK RGMKVALISR SKEKLDQVAG EITEQYGVET KVIVADFGER EDIYDRIRAG 

       130        140        150        160        170        180 
LEGLEIGVLV NNVGISYSYP EYFIDVPDLD KTIDKMININ IMSVCKMTRL VLPGMLERSK 

       190        200        210        220        230        240 
GVILNISSAA GMYPTPLLTL YSASKAFVDY FSRGLHAEYK SKGIIVQSVM PYYVATKMSK 

       250        260        270        280        290        300 
ISKPSFDKPT PETYVRAAIG TVGLQSQTNG CLPHAFMGWV FSILPTSTVM NLLMKTNKQI 

       310 
RARFLKKKMK EK

O57314 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools