ID   DHB3_RAT                Reviewed;         306 AA.
AC   O54939;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-NOV-2008, entry version 54.
DE   RecName: Full=Testosterone 17-beta-dehydrogenase 3;
DE            EC=1.1.1.64;
DE   AltName: Full=Testicular 17-beta-hydroxysteroid dehydrogenase;
DE   AltName: Full=17-beta-HSD 3;
GN   Name=Hsd17b3; Synonyms=Edh17b3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Khanum A., Tsai-Morris C.-H., Dufau M.L.;
RL   Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Favors the reduction of androstenedione to testosterone.
CC       Uses NADPH while the two other EDH17B enzymes use NADH (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Testosterone + NADP(+) = androst-4-ene-3,17-
CC       dione + NADPH.
CC   -!- PATHWAY: Hormone biosynthesis; testosterone biosynthesis.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family. 17-beta-HSD 3 subfamily.
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DR   EMBL; AF035156; AAB99739.1; -; mRNA.
DR   RefSeq; NP_446459.1; -.
DR   UniGene; Rn.10895; -.
DR   Ensembl; ENSRNOG00000019096; Rattus norvegicus.
DR   GeneID; 117182; -.
DR   KEGG; rno:117182; -.
DR   RGD; 621805; Hsd17b3.
DR   HOVERGEN; O54939; -.
DR   NextBio; 620038; -.
DR   ArrayExpress; O54939; -.
DR   GermOnline; ENSRNOG00000019096; Rattus norvegicus.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0047045; F:testosterone 17-beta-dehydrogenase (NADP+) ...; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002198; DHase_sc/Rdtase_SDR.
DR   InterPro; IPR002347; Glc/ribitol_DHase.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR19410; ADH_short_C2; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   PROSITE; PS00061; ADH_SHORT; FALSE_NEG.
PE   2: Evidence at transcript level;
KW   Lipid synthesis; NADP; Oxidoreductase; Steroid biosynthesis.
FT   CHAIN         1    306       Testosterone 17-beta-dehydrogenase 3.
FT                                /FTId=PRO_0000054575.
FT   NP_BIND      44     73       NADP (By similarity).
FT   ACT_SITE    194    194       Proton acceptor (By similarity).
FT   BINDING     181    181       Substrate (By similarity).
SQ   SEQUENCE   306 AA;  34223 MW;  8B88584047614B53 CRC64;
     MEQFLLSVGL LVCLVCLVKC VRFSRYLFLS FCKALPGSFL RSMGQWAVIT GAGDGIGKAY
     SFELARHGLN VVLISRTLEK LQVISEEIER TTGSRVKVVQ ADFTREDIYD HIEEQLKGLE
     IGVLVNNVGM LPNLLPSHFL STSGESQSVI HCNITSVVKM TQLVLKHMES RRRGLILNIS
     SGVGVRPWPL YSLYSASKAF VCTFSKALNV EYRDKGIIIQ VLTPYSVSTP MTKYLNTSRV
     TKTADEFVKE SLKYVTIGAE TCGCLAHEIL AIILNLIPSR IFYSSTTQRF LLKQFSDYLK
     SNISNR
//