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UniProtKB/Swiss-Prot entry O54783

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CHKB_RAT
Primary accession number O54783
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    November 4, 2008 (Entry version 52)
Name and origin of the protein
Protein name Choline/ethanolamine kinase
Synonyms None
Includes Choline kinase beta
     (CK)
     (EC 2.7.1.32)
Ethanolamine kinase
     (EK)
     (EC 2.7.1.82)
Gene name
Name: Chkb
Synonyms: Chetk, Chkl
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
STRAIN=Sprague-Dawley;
TISSUE=Kidney;
DOI=10.1016/S0005-2760(97)00177-X; PubMed=9487136 [NCBI, ExPASy, EBI, Israel, Japan]
Aoyama C., Nakashima K., Matsui M., Ishidate K.;
"Complementary DNA sequence for a 42 kDa rat kidney choline/ethanolamine kinase.";
Biochim. Biophys. Acta 1390:1-7(1998).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Prostate;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB006607; BAA24366.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC060515; AAH60515.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_058873.1; -.
UniGene Rn.1302
3D structure databases
SMR O54783; 41-389, 42-390.
ModBase O54783.
Organism-specific databases
RGD 61826; Chkb.
Gene expression databases
ArrayExpress O54783; -.
GermOnline ENSRNOG00000011404; Rattus norvegicus.
Ontologies
GO
GO:0004103; Molecular function: choline kinase activity (inferred from electronic annotation from EC).
GO:0004305; Molecular function: ethanolamine kinase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR002573; Choline/ethanolamine_kinase.
Graphical view of domain structure.
PANTHER PTHR22603; Choline/ethanolamine_kinase; 1.
Pfam PF01633; Choline_kinase; 1.
Pfam graphical view of domain structure.
Genome annotation databases
Ensembl ENSRNOG00000011404; Rattus norvegicus. [Contig view]
GeneID 29367; -.
KEGG rno:29367; -.
Phylogenomic databases
HOVERGEN O54783; -.
Other
NextBio 608914; -.
ProtoNet O54783.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Direct protein sequencing; Kinase; Phosphoprotein; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   394  393     Choline/ethanolamine kinase. PRO_0000206224
ACT_SITE   240   240        By similarity. 
MOD_RES   2     2        N-acetylalanine (By similarity). 
MOD_RES   39    39        Phosphoserine (By similarity). 
MOD_RES   42    42        Phosphoserine (By similarity). 
Sequence information
Length: 394 AA [This is the length of the unprocessed precursor] Molecular weight: 45100 Da [This is the MW of the unprocessed precursor] CRC64: A2E99EB055E3959E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAADGTGVVG GGAVGGPLSK DGLLDAKCPE PIPNRRRSSS LSRDAQRRAY QWCREYLGGA 

        70         80         90        100        110        120 
WRRARPEELS VCPVSGGLSN LLFRCSLPNH VPSMGGEPRE VLLRLYGAIL QGVDSLVLES 

       130        140        150        160        170        180 
VMFAILAERS LGPQLYGVFP EGRLEQYLPS RPLKTQELRD PVLSGAIATK MARFHGMEMP 

       190        200        210        220        230        240 
FTKEPRWLFG TMERYLKQIQ DLPSTSLPQM NLVEMYSLKD EMNHLRTLLD ATPSPVVFCH 

       250        260        270        280        290        300 
NDIQEGNILL LSEPDSDDNL MLVDFEYSSY NYRGFDIGNH FCEWVYDYTY EEWPFYKARP 

       310        320        330        340        350        360 
ADYPTREQQL LFIRHYLAEV QKGEVLSEEE QKKQEEDLLI EISRYALASH FFWGLWSTLQ 

       370        380        390 
ASMSTIEFGY LEYAQSRFQF YFQQKGQLTS FLSP
O54783 in FASTA format

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