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UniProtKB/Swiss-Prot entry O54537


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G6PD_STRPN
Primary accession number O54537
Secondary accession numbers None
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on September 26, 2001 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 59)
Name and origin of the protein
Protein name Glucose-6-phosphate 1-dehydrogenase
Synonyms G6PD
EC 1.1.1.49
Gene name
Name: zwf
OrderedLocusNames: SP_1243
From
Streptococcus pneumoniae [TaxID: 1313] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-334 / TIGR4;
DOI=10.1126/science.1061217; PubMed=11463916 [NCBI, ExPASy, EBI, Israel, Japan]
Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D., Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M.;
"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae.";
Science 293:498-506(2001).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 281-433.
STRAIN=ATCC 6323;
PubMed=9466257 [NCBI, ExPASy, EBI, Israel, Japan]
Coffey T.J., Enright M.C., Daniels M., Morona J.K., Morona R., Hryniewicz W., Paton J.C., Spratt B.G.;
"Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae.";
Mol. Microbiol. 27:73-83(1998).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 281-433.
PubMed=9533725 [NCBI, ExPASy, EBI, Israel, Japan]
Coffey T.J., Enright M.C., Daniels M., Wilkinson P., Berron S., Fenoll A., Spratt B.G.;
"Serotype 19A variants of the Spanish serotype 23F multiresistant clone of Streptococcus pneumoniae.";
Microb. Drug Resist. 4:51-55(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE005672; AAK75348.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z99802; CAB16927.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z99865; CAB16990.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C95144; C95144.
RefSeq NP_345708.1; -.
3D structure databases
HSSP P11411; 1DPG. [HSSP ENTRY / PDB]
ModBase O54537.
Family and domain databases
InterPro IPR001282; Glc-6-P_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23429; G6PDH; 1.
Pfam PF02781; G6PD_C; 1.
PF00479; G6PD_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000110; G6PD; 1.
PRINTS PR00079; G6PDHDRGNASE.
ProDom PD001129; G6PD; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00871; zwf; 1.
PROSITE PS00069; G6P_DEHYDROGENASE; 1.
BLOCKS O54537.
Genome annotation databases
GeneID 931756; -.
GenomeReviews AE005672_GR; SP_1243.
KEGG spn:SP_1243; -.
TIGR SP_1243; -.
Phylogenomic databases
HOGENOM O54537; -.
Other
ProtoNet O54537.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Carbohydrate metabolism; Complete proteome; Glucose metabolism; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   495  495     Glucose-6-phosphate 1-dehydrogenase. PRO_0000068133
ACT_SITE   239   239        Proton acceptor (By similarity). 
BINDING   13    13        NADP (By similarity). 
BINDING   45    45        NADP (By similarity). 
BINDING   177   177        Substrate (By similarity). 
BINDING   181   181        Substrate (By similarity). 
BINDING   344   344        Substrate (By similarity). 
CONFLICT   348   348        V -> I (in Ref. 2 and 3). 
Sequence information
Length: 495 AA [This is the length of the unprocessed precursor] Molecular weight: 56790 Da [This is the MW of the unprocessed precursor] CRC64: 99093E9C8929FFAF [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSSKVIVTIF GASGDLAKRK LYPSLFRLYQ SGNLSKHFAV IGTARRPWSK EYFESVVVES 

        70         80         90        100        110        120 
ILDLADSTEQ AQEFASHFYY QSHDVNDSEH YIALRQLQAE LNEKYQAEHN KLFFLSMAPQ 

       130        140        150        160        170        180 
FFGTIAKHLK SENIVDGKGF ERLIVEKPFG TDYATASKLN DELLATFDEE QIFRIDHYLG 

       190        200        210        220        230        240 
KEMIQSIFAV RFANLIFENV WNKDFIDNVQ ITFAERLGVE ERGGYYDQSG ALRDMVQNHT 

       250        260        270        280        290        300 
LQLLSLLAMD KPASFTKDEI RAEKIKVFKN LYHPTDEELK EHFIRGQYRS GKIDGMKYIS 

       310        320        330        340        350        360 
YRSEPNVNPE STTETFTSGA FFVDSDRFRG VPFFFRTGKR LTEKGTHVNI VFKQMDSIFG 

       370        380        390        400        410        420 
EPLAPNILTI YIQPTEGFSL SLNGKQVGEE FNLAPNSLDY RTDATATGAS PEPYEKLIYD 

       430        440        450        460        470        480 
VLNNNSTNFS HWDEVCASWK LIDRIEKLWA ENGAPLHDYK AGSMGPQASF DLLEKFGAKW 

       490 
TWQPDITYRQ DGRLE 

O54537 in FASTA format

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