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UniProtKB/Swiss-Prot entry O51581

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G6PD_BORBU
Primary accession number O51581
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on June 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 58)
Name and origin of the protein
Protein name Glucose-6-phosphate 1-dehydrogenase
Synonyms G6PD
EC 1.1.1.49
Gene name
Name: zwf
OrderedLocusNames: BB_0636
From
Borrelia burgdorferi (Lyme disease spirochete) [TaxID: 139] [HAMAP proteome]
Taxonomy Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Borrelia; Borrelia burgdorferi group.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35210 / B31 / CIP 102532 / DSM 4680;
DOI=10.1038/37551; PubMed=9403685 [NCBI, ExPASy, EBI, Israel, Japan]
Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C.;
"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
Nature 390:580-586(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000783; AAB91531.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C70179; C70179.
RefSeq NP_212770.1; -.
3D structure databases
HSSP P11413; 1QKI. [HSSP ENTRY / PDB]
ModBase O51581.
Enzyme and pathway databases
BioCyc BBUR224326:BB_0636-MON; -.
Family and domain databases
InterPro IPR001282; Glc-6-P_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23429; G6PDH; 1.
Pfam PF02781; G6PD_C; 1.
PF00479; G6PD_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000110; G6PD; 1.
PRINTS PR00079; G6PDHDRGNASE.
ProDom PD001129; G6PD; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00871; zwf; 1.
PROSITE PS00069; G6P_DEHYDROGENASE; 1.
BLOCKS O51581.
Genome annotation databases
GeneID 1195488; -.
GenomeReviews AE000783_GR; BB_0636.
KEGG bbu:BB0636; -.
NMPDR fig|224326.1.peg.1020; -.
TIGR BB_0636; -.
Phylogenomic databases
HOGENOM O51581; -.
Other
ProtoNet O51581.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Carbohydrate metabolism; Complete proteome; Glucose metabolism; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   478  478     Glucose-6-phosphate 1-dehydrogenase. PRO_0000068111
ACT_SITE   234   234        Proton acceptor (By similarity). 
BINDING   17    17        NADP (By similarity). 
BINDING   48    48        NADP (By similarity). 
BINDING   172   172        Substrate (By similarity). 
BINDING   176   176        Substrate (By similarity). 
BINDING   339   339        Substrate (By similarity). 
Sequence information
Length: 478 AA [This is the length of the unprocessed precursor] Molecular weight: 56113 Da [This is the MW of the unprocessed precursor] CRC64: 4DDBCE2861161C8A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKERSVSNFD IVIFGVTGNL SRKKLIPSLF NLFKNKCISN FRVIGFSRKI FTDKEFRLYI 

        70         80         90        100        110        120 
KDSLWQEETD SLIEIFLNFF VYVFGDFNEK ESYKNLFKFL DRSRETIYYL STSPAFYGPI 

       130        140        150        160        170        180 
INHLKKYFLS EKLTLSKIVL EKPFGSSLET AKKLNSLLYS AFKEDQIYRI DHYLGKETVQ 

       190        200        210        220        230        240 
NIFTFRFGNS IFENIWNNRY VDFVQITVAE ELGLDGRVEY YDSVGALKDM VQNHILQLLS 

       250        260        270        280        290        300 
LVAMESPIKF DSEFIHDEKV KVLKSLRKIS KEDIKNYIVK GQYIGSQVQG VFKKGYKDET 

       310        320        330        340        350        360 
EFLGNSNTET YLAMKVFINN WRWSGVPFYL RTGKGLARKF SEIYIQFKKP SFTLFNNSSV 

       370        380        390        400        410        420 
DFSNALIFRI QPRDGIEIKF NTKKPGYNYE IQTANMEFSY HGAFKRLFDE AYERLLLDAF 

       430        440        450        460        470 
LGDGTLYATS DEIESSWEFV SDIANKWADI EICNYFYGSE GPKEIDSILE KDHFWRKI
O51581 in FASTA format

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