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UniProtKB/Swiss-Prot entry O48905

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDHC_MEDSA
Primary accession number O48905
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on June 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 64)
Name and origin of the protein
Protein name Malate dehydrogenase, cytoplasmic
Synonym EC 1.1.1.37
Gene name
Name: CMDH
From
Medicago sativa (Alfalfa) [TaxID: 3879] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids I; Fabales; Fabaceae; Papilionoideae; Trifolieae; Medicago.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Saranac;
TISSUE=Root nodule;
PubMed=9721676 [NCBI, ExPASy, EBI, Israel, Japan]
Miller S.S., Driscoll B.T., Gregerson R.G., Gantt J.S., Vance C.P.;
"Alfalfa malate dehydrogenase (MDH): molecular cloning and characterization of five different forms reveals a unique nodule-enhanced MDH.";
Plant J. 15:173-184(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF020272; AAB99756.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T09291; T09291.
3D structure databases
HSSP P11708; 4MDH. [HSSP ENTRY / PDB]
ModBase O48905.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR001252; Malate_DHase_AS.
IPR011274; Malate_DHase_NAD-dep_euk.
IPR010945; Malate_DHase_SF1.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23382; MDH_SF1; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
ProDom PD003052; Mal_dehydrog; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01759; MalateDH-SF1; 1.
TIGR01758; MDH_euk_cyt; 1.
PROSITE PS00068; MDH; 1.
BLOCKS O48905.
Other
ProtoNet O48905.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   332  332     Malate dehydrogenase, cytoplasmic. PRO_0000113416
NP_BIND   12    18  7     NAD (By similarity). 
NP_BIND   130   132  3     NAD (By similarity). 
ACT_SITE   188   188        Proton acceptor (By similarity). 
BINDING   93    93        Substrate (By similarity). 
BINDING   99    99        Substrate (By similarity). 
BINDING   106   106        NAD (By similarity). 
BINDING   113   113        NAD (By similarity). 
BINDING   132   132        Substrate (By similarity). 
BINDING   163   163        Substrate (By similarity). 
Sequence information
Length: 332 AA [This is the length of the unprocessed precursor] Molecular weight: 35547 Da [This is the MW of the unprocessed precursor] CRC64: D9F38F868DE3D628 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAKDPVRVLV TGAAGQIGYA LVPMIARGVM LGPDQPVILH MLDIAPAAES LNGVKMELVD 

        70         80         90        100        110        120 
AAFPLLKGVV ATTDVVEACT GVNIAVMVGG FPRKEGMERK DVMSKNVSIY KSQASALEKH 

       130        140        150        160        170        180 
AAANCKVLVV ANPANTNALI LKEFAPSIPE RNISCLTRLD HNRALGQISE RLNVQVSDVK 

       190        200        210        220        230        240 
NVIIWGNHSS TQYPDVNHAT VNTPAGEKPV RQLVSDDAWL NGEFISTVQQ RGAAIIKARK 

       250        260        270        280        290        300 
LSSALSAASA ACDHIRDWVL GTPQGTFVSM GVYSDGSYNV PSGLIYSFPV TCANGEWKIV 

       310        320        330 
QGLSIDEFSR KKLDLTAEEL TEEKNLAHSC LS
O48905 in FASTA format

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