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UniProtKB/Swiss-Prot entry O46406

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AOCY_BOVIN
Primary accession number O46406
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1999
Sequence was last modified on June 1, 1998 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 59)
Name and origin of the protein
Protein name Primary amine oxidase, lung isozyme [Precursor]
Synonyms EC 1.4.3.21
Copper amine oxidase
Amine oxidase [copper-containing]
BOLAO
Gene name None
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lung;
DOI=10.1046/j.1432-1327.1998.2510320.x; PubMed=9492300 [NCBI, ExPASy, EBI, Israel, Japan]
Hogdall E.V.S., Houen G., Borre M., Bundgaard J.R., Larsson L.-I., Vuust J.;
"Structure and tissue-specific expression of genes encoding bovine copper amine oxidases.";
Eur. J. Biochem. 251:320-328(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Y15774; CAA75776.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
UniGene Bt.4177
3D structure databases
SMR O46406; 57-717.
ModBase O46406.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0008131; Molecular function: amine oxidase activity (inferred from electronic annotation from InterPro).
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005507; Molecular function: copper ion binding (inferred from electronic annotation from InterPro).
GO:0048038; Molecular function: quinone binding (inferred from electronic annotation from InterPro).
GO:0009308; Biological process: cellular amine metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000269; Cu_amine_oxidase.
IPR015798; Cu_amine_oxidase_C.
IPR015800; Cu_amine_oxidase_N2.
IPR015801; Cu_amine_oxidase_N2/3.
IPR015802; Cu_amine_oxidase_N3.
Graphical view of domain structure.
Gene3D G3DSA:3.10.450.40; CuNH_oxidase; 2.
G3DSA:2.70.98.20; Lyase_8_central; 1.
PANTHER PTHR10638; CuNH_oxidase; 1.
Pfam PF01179; Cu_amine_oxid; 1.
PF02727; Cu_amine_oxidN2; 1.
PF02728; Cu_amine_oxidN3; 1.
Pfam graphical view of domain structure.
PRINTS PR00766; CUDAOXIDASE.
PROSITE PS01164; COPPER_AMINE_OXID_1; 1.
PS01165; COPPER_AMINE_OXID_2; 1.
Proteomics databases
PRIDE O46406; -.
Genome annotation databases
Ensembl ENSBTAG00000001041; Bos taurus. [Contig view]
Phylogenomic databases
HOVERGEN O46406; -.
Other
ProtoNet O46406.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Copper; Glycoprotein; Metal-binding; Oxidoreductase; Secreted; Signal; TPQ.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    16  16     Potential. 
CHAIN   17   762  746     Primary amine oxidase, lung isozyme. PRO_0000035670
ACT_SITE   385   385        Proton acceptor (By similarity). 
ACT_SITE   470   470        Schiff-base intermediate with substrate; via topaquinone (By similarity). 
METAL   519   519        Copper (By similarity). 
METAL   521   521        Copper (By similarity). 
METAL   528   528        Calcium 1 (By similarity). 
METAL   529   529        Calcium 1; via carbonyl oxygen (By similarity). 
METAL   530   530        Calcium 1 (By similarity). 
METAL   571   571        Calcium 2 (By similarity). 
METAL   637   637        Calcium 2 (By similarity). 
METAL   662   662        Calcium 2; via carbonyl oxygen (By similarity). 
METAL   664   664        Calcium 2 (By similarity). 
METAL   666   666        Calcium 2 (By similarity). 
METAL   672   672        Calcium 1 (By similarity). 
METAL   673   673        Calcium 1; via carbonyl oxygen (By similarity). 
METAL   683   683        Copper (By similarity). 
MOD_RES   470   470        2',4',5'-topaquinone (By similarity). 
CARBOHYD   136   136        N-linked (GlcNAc...) (Potential). 
CARBOHYD   231   231        N-linked (GlcNAc...) (Potential). 
CARBOHYD   293   293        N-linked (GlcNAc...) (Potential). 
CARBOHYD   617   617        N-linked (GlcNAc...) (Potential). 
CARBOHYD   665   665        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 762 AA [This is the length of the unprocessed precursor] Molecular weight: 84883 Da [This is the MW of the unprocessed precursor] CRC64: BB43D04776744AF2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MFIFIFLSLW TLLVMGREEG GVGSEEGVGK QCHPSLPPRC PSRSPSDQPW THPDQSQLFA 

        70         80         90        100        110        120 
DLSREELTAV MSFLTQKLGP DLVDAAQARP SDNCIFSVEL QLPPKAAALA HLDRRSPPPA 

       130        140        150        160        170        180 
REALAIVFFG GQPQPNVTEL VVGPLPQPSY MRDVTVERHG GPLPYYRHTV LLREYLDIDQ 

       190        200        210        220        230        240 
MIFNRELPQA AGVLHHCCSY KQGGGNLVTM TTAPPGLQSG DRATWFGLYY NISKAGYYLH 

       250        260        270        280        290        300 
PVGLELLVDH KALDPAQWTI QKVFFQGRYY ESLVQLEEQF EAGRVNVVVI PNNGTGGSWS 

       310        320        330        340        350        360 
LKSQVPPGPT PPLQFHPQGT RFSVQGSRVT SSLWTFSFGL GAFSGPRIFD IRFQGERLAY 

       370        380        390        400        410        420 
EISLQEAVAI YGGNTPAAML TRYMDACFGM GKFATPLTRG VDCPYLATYV DWHFLLESQA 

       430        440        450        460        470        480 
PKTLHDAFCV FEQNKGLPLR RHHSDFISQY FGGVVETVLV FRSVSTLLNY DYVWDMVFHP 

       490        500        510        520        530        540 
NGAIEVKFHV TGYISSAFFF GTAQKYGNQV RENTLGTVHT HSAHYKVDLD VGGLENWVWA 

       550        560        570        580        590        600 
EDMAFVPTTV PWSPEHQIQR LQVIRKQLET EEQAAFPLGG GSPRYLYLAS KQSNKWGHPR 

       610        620        630        640        650        660 
GYRIQTVSFA GRPLPQNSST ERAISWGRYQ LAVTQRKETE PSSSSVFNQN DPWTPTVDFA 

       670        680        690        700        710        720 
DFINNETIAG KDLVAWVTAG FLHIPHAEDI PNTVTVGNGV GFFLRPYNFF DQEPSMDSAD 

       730        740        750        760 
SIYFREGQDA GSCEINPLAC LPQAATCAPD LPVFSHGGYP EY
O46406 in FASTA format

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