[1]	NUCLEOTIDE SEQUENCE. DOI=10.1073/pnas.94.22.12186; PubMed=9342384 [NCBI, ExPASy, EBI, Israel, Japan] O'Connor V., Heuss C., De Bello W.M., Dresbach T., Charlton M.P., Hunt J.H., Pellegrini L.L., Hodel A., Burger M.M., Betz H., Augustine G.J., Schafer T.; "Disruption of syntaxin-mediated protein interactions blocks neurotransmitter secretion."; Proc. Natl. Acad. Sci. U.S.A. 94:12186-12191(1997).
[2]	NUCLEOTIDE SEQUENCE. TISSUE=Optic lobe; DOI=10.1016/S0306-4522(97)00689-1; PubMed=9692742 [NCBI, ExPASy, EBI, Israel, Japan] Sugimori M., Tong C.-T., Fukuda M., Moreira J.E., Kojima T., Mikoshiba K., Llinas R.; "Presynaptic injection of syntaxin-specific antibodies blocks transmission in the squid giant synapse."; Neuroscience 86:39-51(1998).

Comments

SIMILARITY: Belongs to the syntaxin family.
SIMILARITY: Contains 1 t-SNARE coiled-coil homology domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

D78271; BAA24019.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
Y14575; CAA74913.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

O46345; 32-250.

ModBase

O46345.

Protein-protein interaction databases

IntAct

O46345; -.

Ontologies

GO:0016020;	Cellular component: membrane (inferred from electronic annotation from InterPro).
GO:0005484;	Molecular function: SNAP receptor activity (inferred from electronic annotation from InterPro).
GO:0006886;	Biological process: intracellular protein transport (inferred from electronic annotation from InterPro).
GO:0016192;	Biological process: vesicle-mediated transport (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR006012; Syntaxin/epimorphin_CS.
IPR006011; Syntaxin_N.
IPR000727; T_SNARE.
Graphical view of domain structure.

Pfam

PF05739; SNARE; 1.
PF00804; Syntaxin; 1.
Pfam graphical view of domain structure.

SMART

SM00503; SynN; 1.
SM00397; t_SNARE; 1.
SMART graphical view of domain structure.

PROSITE

PS00914; SYNTAXIN; 1.
PS50192; T_SNARE; 1.
PROSITE graphical view of domain structure (profiles).

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

None

Features

None

Sequence information

Length: 292 AA

Molecular weight: 33142 Da

CRC64: BF8B2186D36FE9C8 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTKDRLAALK AAVSDEEDVE EVAVQVDSGG GFMEEFFEQV EEIRAMIDKI SDNVDAVKKK 

        70         80         90        100        110        120 
HSDILSAPQT DDQMKEELEE LMTDIKRTAN KVRGKLKTIE LNIEQEEHSN KSSADLRIRK 

       130        140        150        160        170        180 
TQYSTISRKF VEVMSDYNTT QIDYRDRCKA RIKRQMEITG RTTTNEELED MLESGNPAIF 

       190        200        210        220        230        240 
TQGIIMETQQ AKQTLADIEA RHADIMKLET SIRELHDMFM DMAMLVESQG EMIDRIEYNV 

       250        260        270        280        290 
EAAVDYIETA KVDTKKAVKY QSKARQKKIA ILVCLVILVL VIVSTVGGVF GG

O46345 in FASTA format

View entry in original UniProtKB/TrEMBL format
View entry in raw text format (no links)
Request for annotation of this UniProtKB/TrEMBL entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools