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UniProtKB/Swiss-Prot entry O43896


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KIF1C_HUMAN
Primary accession number O43896
Secondary accession numbers O75186 Q5U618
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on October 17, 2006 (Sequence version 3)
Annotations were last modified on    June 16, 2009 (Entry version 87)
Name and origin of the protein
Protein name Kinesin-like protein KIF1C
Synonyms None
Gene name
Name: KIF1C
Synonyms: KIAA0706
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PHOSPHORYLATION, AND TISSUE SPECIFICITY.
TISSUE=Hippocampus;
DOI=10.1074/jbc.273.32.20267; PubMed=9685376 [NCBI, ExPASy, EBI, Israel, Japan]
Dorner C., Ciossek T., Mueller S., Moeller N.P.H., Ullrich A., Lammers R.;
"Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum.";
J. Biol. Chem. 273:20267-20275(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1093/dnares/5.3.169; PubMed=9734811 [NCBI, ExPASy, EBI, Israel, Japan]
Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.";
DNA Res. 5:169-176(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-494, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1038/nbt1240; PubMed=16964243 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1033 AND SER-1092, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1083, AND MASS SPECTROMETRY.
DOI=10.1021/pr0705441; PubMed=18220336 [NCBI, ExPASy, EBI, Israel, Japan]
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.";
J. Proteome Res. 7:1346-1351(2008).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1083 AND SER-1092, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[8]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
[9]
X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 498-599.
Structural genomics consortium (SGC);
"Crystal structure of the FHA domain of human kinesin family member C.";
Submitted (FEB-2006) to the PDB data bank.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U91329; AAC52117.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB014606; BAA31681.2; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC034993; AAH34993.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00179757; -.
RefSeq NP_006603.2; -.
UniGene Hs.435120
3D structure databases
PDB
2G1L; X-ray; 2.60 A; A=498-599.[ExPASy / RCSB / EBI]
PDBsum 2G1L; -.
SMR O43896; 4-347.
ModBase O43896.
PTM databases
PhosphoSite O43896; -.
Organism-specific databases
GeneCards GC17P004843; -.
H-InvDB HIX0013460; -.
HGNC HGNC:6317; KIF1C.
GenAtlas KIF1C.
MIM 603060; gene. [NCBI / EBI]
PharmGKB PA30100; -.
HUGE KIAA0706.
Gene expression databases
ArrayExpress O43896; -.
Bgee O43896; -.
CleanEx HS_KIF1C; -.
GermOnline ENSG00000129250; Homo sapiens.
Ontologies
GO
GO:0005783; Cellular component: endoplasmic reticulum (traceable author statement from ProtInc).
GO:0005794; Cellular component: Golgi apparatus (traceable author statement from ProtInc).
GO:0005874; Cellular component: microtubule (inferred from electronic annotation from UniProtKB-KW).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from UniProtKB-KW).
GO:0003777; Molecular function: microtubule motor activity (inferred from electronic annotation from InterPro).
GO:0007018; Biological process: microtubule-based movement (inferred from electronic annotation from InterPro).
GO:0006890; Biological process: retrograde vesicle-mediated transport, Golgi to ER (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR000253; FHA.
IPR001752; Kinesin_motor.
IPR019821; Kinesin_motor_CS.
Graphical view of domain structure.
Gene3D G3DSA:3.40.850.10; kinesin_motor; 1.
Pfam PF00498; FHA; 1.
PF00225; Kinesin; 1.
Pfam graphical view of domain structure.
PRINTS PR00380; KINESINHEAVY.
SMART SM00240; FHA; 1.
SM00129; KISc; 1.
SMART graphical view of domain structure.
PROSITE PS50006; FHA_DOMAIN; FALSE_NEG.
PS00411; KINESIN_MOTOR_DOMAIN1; 1.
PS50067; KINESIN_MOTOR_DOMAIN2; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE O43896; -.
Genome annotation databases
Ensembl ENSG00000129250; Homo sapiens. [Contig view]
GeneID 10749; -.
KEGG hsa:10749; -.
Phylogenomic databases
HOGENOM O43896; -.
HOVERGEN O43896; -.
OMA O43896; RELCRTY.
Other
NextBio 40821; -.
SOURCE KIF1C; Homo sapiens.
ProtoNet O43896.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; ATP-binding; Coiled coil; Microtubule; Motor protein; Nucleotide-binding; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1103  1103     Kinesin-like protein KIF1C. PRO_0000125410
DOMAIN   1    273  273     Kinesin-motor. 
DOMAIN   523    590  68     FHA. 
NP_BIND   97    104  8     ATP (By similarity). 
COILED   359    388  30     Potential. 
COILED   438    479  42     Potential. 
COILED   633    674  42     Potential. 
COILED   828    872  45     Potential. 
COMPBIAS   965   1085  121     Pro-rich. 
MOD_RES   494    494        Phosphoserine. 
MOD_RES   674    674        Phosphoserine (By similarity). 
MOD_RES   676    676        Phosphoserine (By similarity). 
MOD_RES   1033   1033        Phosphoserine. 
MOD_RES   1083   1083        Phosphothreonine. 
MOD_RES   1092   1092        Phosphoserine. 
CONFLICT   669    669        R -> Q (in Ref. 1; AAC52117). 
CONFLICT   955    962        SGGRGGGL -> LWGPGRGV (in Ref. 1; AAC52117). 
CONFLICT   976    977        KL -> NV (in Ref. 1; AAC52117). 
STRAND   500    503  4      
STRAND   510    512  3      
STRAND   515    517  3      
STRAND   520    529  10      
STRAND   531    533  3      
STRAND   541    550  10      
STRAND   556    562  7      
STRAND   568    570  3      
STRAND   586    589  4      
TURN   590    592  3      
STRAND   593    598  6      
Sequence information
Length: 1103 AA [This is the length of the unprocessed precursor] Molecular weight: 122947 Da [This is the MW of the unprocessed precursor] CRC64: 5FDEEB8C91B3C46B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAGASVKVAV RVRPFNARET SQDAKCVVSM QGNTTSIINP KQSKDAPKSF TFDYSYWSHT 

        70         80         90        100        110        120 
STEDPQFASQ QQVYRDIGEE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGR QEPGQQGIVP 

       130        140        150        160        170        180 
QLCEDLFSRV SENQSAQLSY SVEVSYMEIY CERVRDLLNP KSRGSLRVRE HPILGPYVQD 

       190        200        210        220        230        240 
LSKLAVTSYA DIADLMDCGN KARTVAATNM NETSSRSHAV FTIVFTQRCH DQLTGLDSEK 

       250        260        270        280        290        300 
VSKISLVDLA GSERADSSGA RGMRLKEGAN INKSLTTLGK VISALADMQS KKRKSDFIPY 

       310        320        330        340        350        360 
RDSVLTWLLK ENLGGNSRTA MIAALSPADI NYEETLSTLR YADRTKQIRC NAIINEDPNA 

       370        380        390        400        410        420 
RLIRELQEEV ARLRELLMAQ GLSASALEGL KTEEGSVRGA LPAVSSPPAP VSPSSPTTHN 

       430        440        450        460        470        480 
GELEPSFSPN TESQIGPEEA MERLQETEKI IAELNETWEE KLRKTEALRM EREALLAEMG 

       490        500        510        520        530        540 
VAVREDGGTV GVFSPKKTPH LVNLNEDPLM SECLLYHIKD GVTRVGQVDM DIKLTGQFIR 

       550        560        570        580        590        600 
EQHCLFRSIP QPDGEVVVTL EPCEGAETYV NGKLVTEPLV LKSGNRIVMG KNHVFRFNHP 

       610        620        630        640        650        660 
EQARLERERG VPPPPGPPSE PVDWNFAQKE LLEQQGIDIK LEMEKRLQDL ENQYRKEKEE 

       670        680        690        700        710        720 
ADLLLEQQRL YADSDSGDDS DKRSCEESWR LISSLREQLP PTTVQTIVKR CGLPSSGKRR 

       730        740        750        760        770        780 
APRRVYQIPQ RRRLQGKDPR WATMADLKMQ AVKEICYEVA LADFRHGRAE IEALAALKMR 

       790        800        810        820        830        840 
ELCRTYGKPD GPGDAWRAVA RDVWDTVGEE EGGGAGSGGG SEEGARGAEV EDLRAHIDKL 

       850        860        870        880        890        900 
TGILQEVKLQ NSSKDRELQA LRDRMLRMER VIPLAQDHED ENEEGGEVPW APPEGSEAAE 

       910        920        930        940        950        960 
EAAPSDRMPS ARPPSPPLSS WERVSRLMEE DPAFRRGRLR WLKQEQLRLQ GLQGSGGRGG 

       970        980        990       1000       1010       1020 
GLRRPPARFV PPHDCKLRFP FKSNPQHRES WPGMGSGEAP TPLQPPEEVT PHPATPARRP 

      1030       1040       1050       1060       1070       1080 
PSPRRSHHPR RNSLDGGGRS RGAGSAQPEP QHFQPKKHNS YPQPPQPYPA QRPPGPRYPP 

      1090       1100 
YTTPPRMRRQ RSAPDLKESG AAV 

O43896 in FASTA format

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