[1]
|
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/S0014-5793(97)01340-9; PubMed=9414087 [NCBI, ExPASy, EBI, Israel, Japan]
Nagai Y.,
Kojima T.,
Muro Y.,
Hachiya T.,
Nishizawa Y.,
Wakabayashi T.,
Hagiwara M.;
"Identification of a novel nuclear speckle-type protein, SPOP.";
FEBS Lett. 418:23-26(1997).
|
[2]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Coronary artery;
Suzuki Y.,
Sugano S.,
Totoki Y.,
Toyoda A.,
Takeda T.,
Sakaki Y.,
Tanaka A.,
Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
|
[3]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Cervix, and Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
|
[4]
|
FUNCTION AS A E3 UBIQUITIN-PROTEIN LIGASE, AND INTERACTION WITH CUL3.
DOI=10.1038/ncb1056; PubMed=14528312 [NCBI, ExPASy, EBI, Israel, Japan]
Furukawa M.,
He Y.J.,
Borchers C.,
Xiong Y.;
"Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.";
Nat. Cell Biol. 5:1001-1007(2003).
|
[5]
|
INTERACTION WITH DAXX, AND HOMODIMERIZATION.
DOI=10.1016/j.bbrc.2004.06.022; PubMed=15240113 [NCBI, ExPASy, EBI, Israel, Japan]
La M.,
Kim K.,
Park J.,
Won J.,
Lee J.-H.,
Fu Y.M.,
Meadows G.G.,
Joe C.O.;
"Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP.";
Biochem. Biophys. Res. Commun. 320:760-765(2004).
|
[6]
|
INTERACTION WITH BMI1, IDENTIFICATION IN A COMPLEX WITH CUL3 AND BMI1, IDENTIFICATION IN A COMPLEX WITH CUL3 AND H2AFY, SUBCELLULAR LOCATION, AND FUNCTION.
DOI=10.1073/pnas.0408918102; PubMed=15897469 [NCBI, ExPASy, EBI, Israel, Japan]
Hernandez-Munoz I.,
Lund A.H.,
van der Stoop P.,
Boutsma E.,
Muijrers I.,
Verhoeven E.,
Nusinow D.A.,
Panning B.,
Marahrens Y.,
van Lohuizen M.;
"Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase.";
Proc. Natl. Acad. Sci. U.S.A. 102:7635-7640(2005).
|
[7]
|
IDENTIFICATION.
DOI=10.1242/dev.02370; PubMed=16651542 [NCBI, ExPASy, EBI, Israel, Japan]
Kent D.,
Bush E.W.,
Hooper J.E.;
"Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.";
Development 133:2001-2010(2006).
|
[8]
|
IDENTIFICATION.
DOI=10.1016/j.devcel.2006.05.004; PubMed=16740475 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Q.,
Zhang L.,
Wang B.,
Ou C.-Y.,
Chien C.-T.,
Jiang J.;
"A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.";
Dev. Cell 10:719-729(2006).
|
[9]
|
IDENTIFICATION IN A COMPLEX WITH CUL3 AND DAXX, AND FUNCTION.
DOI=10.1074/jbc.M600204200; PubMed=16524876 [NCBI, ExPASy, EBI, Israel, Japan]
Kwon J.E.,
La M.,
Oh K.H.,
Oh Y.M.,
Kim G.R.,
Seol J.H.,
Baek S.H.,
Chiba T.,
Tanaka K.,
Bang O.S.,
Joe C.O.,
Chung C.H.;
"BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.";
J. Biol. Chem. 281:12664-12672(2006).
|
[10]
|
STRUCTURE BY NMR OF 28-173.
RIKEN structural genomics initiative (RSGI);
"Solution structure of N-terminal domain of speckle-type POZ protein.";
Submitted (NOV-2005) to the PDB data bank.
|
|
- FUNCTION: Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (By similarity). In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3.
- PATHWAY: Protein modification; protein ubiquitination.
- SUBUNIT: Homodimer. Part of a complex consisting of BMI1, CUL3 and SPOP. Part of a complex consisting of H2AFY, CUL3 and SPOP. Part of a complex consisting of DAXX, CUL3 and SPOP. Interacts with H2AFY, IPF1/PDX1, BMI1 and DAXX. Interacts with CUL3.
- INTERACTION:
O60496:DOK2; NbExp=1; IntAct=EBI-743549, EBI-1046024;
P31150:GDI1; NbExp=1; IntAct=EBI-743549, EBI-946999;
O60684:KPNA6; NbExp=1; IntAct=EBI-743549, EBI-359923;
O14986:PIP5K1B; NbExp=1; IntAct=EBI-743549, EBI-1053734;
Q8IXJ6:SIRT2; NbExp=1; IntAct=EBI-743549, EBI-477232;
- SUBCELLULAR LOCATION: Nucleus.
- TISSUE SPECIFICITY: Widely expressed.
- DOMAIN: The MATH domain interacts with H2AFY and BMI1.
- MISCELLANEOUS: Antigen recognized by serum from scleroderma patient.
- SIMILARITY: Belongs to the Tdpoz family.
- SIMILARITY: Contains 1 BTB (POZ) domain.
- SIMILARITY: Contains 1 MATH domain.
|
ExPASy Home page
SIB Switzerland
