[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION OF VARIANT EBN2 VAL-310, AND MUTAGENESIS OF GLY-318.
TISSUE=Brain;
DOI=10.1038/25367; PubMed=9872318 [NCBI, ExPASy, EBI, Israel, Japan]
Schroeder B.C.,
Kubisch C.,
Stein V.,
Jentsch T.J.;
"Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy.";
Nature 396:687-690(1998).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] OF 48-872, AND VARIANT EBN2 VAL-310.
TISSUE=Brain;
DOI=10.1038/ng0198-53; PubMed=9425900 [NCBI, ExPASy, EBI, Israel, Japan]
Charlier C.,
Singh N.A.,
Ryan S.G.,
Lewis T.B.,
Reus B.E.,
Leach R.J.,
Leppert M.;
"A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family.";
Nat. Genet. 18:53-55(1998).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
TISSUE=Brain, and Fetal brain;
DOI=10.1074/jbc.273.31.19419; PubMed=9677360 [NCBI, ExPASy, EBI, Israel, Japan]
Yang W.-P.,
Levesque P.C.,
Little W.A.,
Conder M.L.,
Ramakrishnan P.,
Neubauer M.G.,
Blanar M.A.;
"Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy.";
J. Biol. Chem. 273:19419-19423(1998).
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[4]
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INVOLVEMENT IN M-LIKE CURRENT.
PubMed=10479678 [NCBI, ExPASy, EBI, Israel, Japan]
Selyanko A.A.,
Hadley J.K.,
Wood I.C.,
Abogadie F.C.,
Delmas P.,
Buckley N.J.,
London B.,
Brown D.A.;
"Two types of K(+) channel subunit, Erg1 and KCNQ2/3, contribute to the M-like current in a mammalian neuronal cell.";
J. Neurosci. 19:7742-7756(1999).
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[5]
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ASSOCIATION WITH KCNE2.
DOI=10.1016/S0014-5793(00)01918-9; PubMed=11034315 [NCBI, ExPASy, EBI, Israel, Japan]
Tinel N.,
Diochot S.,
Lauritzen I.,
Barhanin J.,
Lazdunski M.,
Borsotto M.;
"M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit.";
FEBS Lett. 480:137-141(2000).
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[6]
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SURFACE EXPRESSION OF HETEROMERS.
DOI=10.1074/jbc.275.18.13343; PubMed=10788442 [NCBI, ExPASy, EBI, Israel, Japan]
Schwake M.,
Pusch M.,
Kharkovets T.,
Jentsch T.J.;
"Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy.";
J. Biol. Chem. 275:13343-13348(2000).
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[7]
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INHIBITION BY M1 MUSCARINIC RECEPTORS.
PubMed=10684873 [NCBI, ExPASy, EBI, Israel, Japan]
Shapiro M.S.,
Roche J.P.,
Kaftan E.J.,
Cruzblanca H.,
Mackie K.,
Hille B.;
"Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current.";
J. Neurosci. 20:1710-1721(2000).
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[8]
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INHIBITION BY M1 MUSCARINIC RECEPTORS.
DOI=10.1111/j.1469-7793.2000.t01-2-00349.x; PubMed=10713961 [NCBI, ExPASy, EBI, Israel, Japan]
Selyanko A.A.,
Hadley J.K.,
Wood I.C.,
Abogadie F.C.,
Jentsch T.J.,
Brown D.A.;
"Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors.";
J. Physiol. (Lond.) 522:349-355(2000).
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[9]
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ACTIVATION BY RETICABINE.
PubMed=10908292 [NCBI, ExPASy, EBI, Israel, Japan]
Main M.J.,
Cryan J.E.,
Dupere J.R.,
Cox B.,
Clare J.J.,
Burbidge S.A.;
"Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine.";
Mol. Pharmacol. 58:253-262(2000).
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[10]
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ACTIVATION BY RETICABINE.
PubMed=10953053 [NCBI, ExPASy, EBI, Israel, Japan]
Wickenden A.D.,
Yu W.,
Zou A.,
Jegla T.,
Wagoner P.K.;
"Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels.";
Mol. Pharmacol. 58:591-600(2000).
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[11]
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ACTIVATION BY RETICABINE.
DOI=10.1016/S0304-3940(00)00866-1; PubMed=10713399 [NCBI, ExPASy, EBI, Israel, Japan]
Rundfeldt C.,
Netzer R.;
"The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits.";
Neurosci. Lett. 282:73-76(2000).
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[12]
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CHARACTERIZATION, AND ACTIVATION BY RETICABINE.
DOI=10.1038/sj.bjp.0703861; PubMed=11159685 [NCBI, ExPASy, EBI, Israel, Japan]
Wickenden A.D.,
Zou A.,
Wagoner P.K.,
Jegla T.;
"Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells.";
Br. J. Pharmacol. 132:381-384(2001).
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[13]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-746, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1021/pr070152u; PubMed=17924679 [NCBI, ExPASy, EBI, Israel, Japan]
Yu L.-R.,
Zhu Z.,
Chan K.C.,
Issaq H.J.,
Dimitrov D.S.,
Veenstra T.D.;
"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
J. Proteome Res. 6:4150-4162(2007).
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[14]
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VARIANT EBN2 ARG-309.
DOI=10.1002/1531-8249(200006)47:6<822::AID-ANA19>3.3.CO;2-O; PubMed=10852552 [NCBI, ExPASy, EBI, Israel, Japan]
Hirose S.,
Zenri F.,
Akiyoshi H.,
Fukuma G.,
Iwata H.,
Inoue T.,
Yonetani M.,
Tsutsumi M.,
Muranaka H.,
Kurokawa T.,
Hanai T.,
Wada K.,
Kaneko S.,
Mitsudome A.;
"A novel mutation of KCNQ3 (c.925T-->C) in a Japanese family with benign familial neonatal convulsions.";
Ann. Neurol. 47:822-826(2000).
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[15]
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VARIANTS EBN2 GLY-305 AND VAL-310, CHARACTERIZATION OF VARIANT EBN2 GLY-305, VARIANT SER-468, AND CHARACTERIZATION OF VARIANT SER-468.
DOI=10.1093/brain/awg286; PubMed=14534157 [NCBI, ExPASy, EBI, Israel, Japan]
The BFNC physician consortium;
Singh N.A.,
Westenskow P.,
Charlier C.,
Pappas C.,
Leslie J.,
Dillon J.,
Anderson V.E.,
Sanguinetti M.C.,
Leppert M.F.;
"KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum.";
Brain 126:2726-2737(2003).
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