ID   BIM_HUMAN               Reviewed;         198 AA.
AC   O43521; O43522;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   22-JUL-2008, entry version 69.
DE   RecName: Full=Bcl-2-like protein 11;
DE   AltName: Full=Bcl2-interacting mediator of cell death;
GN   Name=BCL2L11; Synonyms=BIM;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BIMEL AND BIML), AND FUNCTION.
RC   TISSUE=Peripheral blood, and Spleen;
RX   MEDLINE=98094360; PubMed=9430630; DOI=10.1093/emboj/17.2.384;
RA   O'Connor L., Strasser A., O'Reilly L.A., Hausmann G., Adams J.M.,
RA   Cory S., Huang D.C.S.;
RT   "Bim: a novel member of the Bcl-2 family that promotes apoptosis.";
RL   EMBO J. 17:384-395(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BIMEL).
RC   TISSUE=Blood;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77, AND MASS
RP   SPECTROMETRY.
RX   PubMed=18220336; DOI=10.1021/pr0705441;
RA   Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,
RA   Yates J.R. III;
RT   "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for
RT   efficient phosphoproteomic analysis.";
RL   J. Proteome Res. 7:1346-1351(2008).
CC   -!- FUNCTION: Induces apoptosis. Isoform BimL is more potent than
CC       isoform BimEL.
CC   -!- SUBUNIT: Forms heterodimers with a number of antiapoptotic Bcl-2
CC       proteins including Mcl-1, Bcl-2, Bcl-X(L), BFL-1, and BHRF1. Does
CC       not heterodimerize with proapoptotic proteins such as BAD, BOK,
CC       BAX or BAK (By similarity).
CC   -!- INTERACTION:
CC       P31749:AKT1; NbExp=1; IntAct=EBI-526416, EBI-296087;
CC       P10415:BCL2; NbExp=1; IntAct=EBI-526406, EBI-77694;
CC       P10415:BCL2; NbExp=2; IntAct=EBI-526420, EBI-77694;
CC       P10415:BCL2; NbExp=1; IntAct=EBI-526416, EBI-77694;
CC       Q07440:Bcl2a1 (xeno); NbExp=1; IntAct=EBI-526406, EBI-707754;
CC       Q07817-1:BCL2L1; NbExp=4; IntAct=EBI-526406, EBI-287195;
CC       Q07817-1:BCL2L1; NbExp=1; IntAct=EBI-526416, EBI-287195;
CC       Q92843:BCL2L2; NbExp=1; IntAct=EBI-526406, EBI-707714;
CC       Q9NP97:DYNLRB1; NbExp=1; IntAct=EBI-526406, EBI-372128;
CC       P63085:Mapk1 (xeno); NbExp=1; IntAct=EBI-526416, EBI-397697;
CC       P97287:Mcl1 (xeno); NbExp=3; IntAct=EBI-526406, EBI-707292;
CC       P31946:YWHAB; NbExp=1; IntAct=EBI-526406, EBI-359815;
CC   -!- SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
CC       Note=Associated with intracytoplasmic membranes (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=BimEL;
CC         IsoId=O43521-1; Sequence=Displayed;
CC       Name=BimL;
CC         IsoId=O43521-2; Sequence=VSP_000535;
CC   -!- DOMAIN: The BH3 motif is required for Bcl-2 binding and
CC       cytotoxicity.
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DR   EMBL; AF032457; AAC39593.1; -; mRNA.
DR   EMBL; AF032458; AAC39594.1; -; mRNA.
DR   EMBL; BC033694; AAH33694.1; -; mRNA.
DR   RefSeq; NP_006529.1; -.
DR   RefSeq; NP_619527.1; -.
DR   UniGene; Hs.469658; -.
DR   PDB; 2NL9; X-ray; 1.55 A; B=141-166.
DR   PDB; 2VM6; X-ray; 2.20 A; B=141-165.
DR   PDBsum; 2NL9; -.
DR   PDBsum; 2VM6; -.
DR   DIP; DIP:29185N; -.
DR   IntAct; O43521; -.
DR   PhosphoSite; O43521; -.
DR   Ensembl; ENSG00000153094; Homo sapiens.
DR   GeneID; 10018; -.
DR   KEGG; hsa:10018; -.
DR   HGNC; HGNC:994; BCL2L11.
DR   HPA; CAB002616; -.
DR   MIM; 603827; gene.
DR   PharmGKB; PA25305; -.
DR   HOGENOM; O43521; -.
DR   HOVERGEN; O43521; -.
DR   Reactome; REACT_578; Apoptosis.
DR   LinkHub; O43521; -.
DR   ArrayExpress; O43521; -.
DR   CleanEx; HS_BCL2L11; -.
DR   GermOnline; ENSG00000153094; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; EXP:Reactome.
DR   GO; GO:0005624; C:membrane fraction; TAS:ProtInc.
DR   GO; GO:0005741; C:mitochondrial outer membrane; EXP:Reactome.
DR   GO; GO:0005886; C:plasma membrane; EXP:Reactome.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0008633; P:activation of pro-apoptotic gene products; EXP:Reactome.
DR   GO; GO:0006917; P:induction of apoptosis; TAS:UniProtKB.
DR   InterPro; IPR017288; Apoptosis_Bcl-2-like_11.
DR   InterPro; IPR014771; Apoptosis_Bim_N.
DR   InterPro; IPR000712; Bcl2_BH.
DR   InterPro; IPR015040; Bclx_interact.
DR   Pfam; PF08945; Bclx_interact; 1.
DR   Pfam; PF06773; Bim_N; 1.
DR   PIRSF; PIRSF037827; Bcl-2-like_p11; 1.
DR   PROSITE; PS01259; BH3; FALSE_NEG.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Apoptosis; Membrane;
KW   Phosphoprotein.
FT   CHAIN         1    198       Bcl-2-like protein 11.
FT                                /FTId=PRO_0000143109.
FT   MOTIF       148    162       BH3.
FT   MOD_RES      77     77       Phosphoserine.
FT   VAR_SEQ      42    101       Missing (in isoform BimL).
FT                                /FTId=VSP_000535.
FT   HELIX       144    164
SQ   SEQUENCE   198 AA;  22171 MW;  D75735E469CA6997 CRC64;
     MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
     QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
     CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
     MVILRLLRYI VRLVWRMH
//