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[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BIMEL AND BIML), AND FUNCTION.
TISSUE=Peripheral blood, and Spleen;
DOI=10.1093/emboj/17.2.384; PubMed=9430630 [NCBI, ExPASy, EBI, Israel, Japan]
O'Connor L.,
Strasser A.,
O'Reilly L.A.,
Hausmann G.,
Adams J.M.,
Cory S.,
Huang D.C.S.;
"Bim: a novel member of the Bcl-2 family that promotes apoptosis.";
EMBO J. 17:384-395(1998).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BIMEL).
TISSUE=Blood;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[3]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77, AND MASS SPECTROMETRY.
DOI=10.1021/pr0705441; PubMed=18220336 [NCBI, ExPASy, EBI, Israel, Japan]
Cantin G.T.,
Yi W.,
Lu B.,
Park S.K.,
Xu T.,
Lee J.-D.,
Yates J.R. III;
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.";
J. Proteome Res. 7:1346-1351(2008).
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- FUNCTION: Induces apoptosis. Isoform BimL is more potent than isoform BimEL.
- SUBUNIT: Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including Mcl-1, Bcl-2, Bcl-X(L), BFL-1, and BHRF1. Does not heterodimerize with proapoptotic proteins such as BAD, BOK, BAX or BAK (By similarity).
- INTERACTION:
P31749:AKT1; NbExp=1; IntAct=EBI-526416, EBI-296087;
P10415:BCL2; NbExp=1; IntAct=EBI-526406, EBI-77694;
P10415:BCL2; NbExp=2; IntAct=EBI-526420, EBI-77694;
P10415:BCL2; NbExp=1; IntAct=EBI-526416, EBI-77694;
Q07440:Bcl2a1 (xeno); NbExp=1; IntAct=EBI-526406, EBI-707754;
Q07817-1:BCL2L1; NbExp=4; IntAct=EBI-526406, EBI-287195;
Q07817-1:BCL2L1; NbExp=1; IntAct=EBI-526416, EBI-287195;
Q92843:BCL2L2; NbExp=1; IntAct=EBI-526406, EBI-707714;
Q9NP97:DYNLRB1; NbExp=1; IntAct=EBI-526406, EBI-372128;
P63085:Mapk1 (xeno); NbExp=1; IntAct=EBI-526416, EBI-397697;
P97287:Mcl1 (xeno); NbExp=3; IntAct=EBI-526406, EBI-707292;
P31946:YWHAB; NbExp=1; IntAct=EBI-526406, EBI-359815;
- SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Note=Associated with intracytoplasmic membranes (By similarity).
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
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| Name | BimL |
| Isoform ID | O43521-2 |
| Features which should be applied to build the isoform sequence: VSP_000535. |
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- DOMAIN: The BH3 motif is required for Bcl-2 binding and cytotoxicity.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 198 AA [This is the length of the unprocessed precursor] |
Molecular weight: 22171 Da [This is the MW of the unprocessed precursor] |
CRC64: D75735E469CA6997 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
70 80 90 100 110 120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
130 140 150 160 170 180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
190
MVILRLLRYI VRLVWRMH
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O43521 in FASTA format |
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