[1]	NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PFIC1 SER-288; VAL-308; 645-ILE--ILE-699 DEL AND ARG-892, VARIANTS BRIC1 THR-661 AND 795-GLY--ARG-797 DEL, AND VARIANT THR-1152. TISSUE=Intestine, and Liver; DOI=10.1038/ng0398-219; PubMed=9500542 [NCBI, ExPASy, EBI, Israel, Japan] Bull L.N., van Eijk M.J.T., Pawlikowska L., DeYoung J.A., Juijn J.A., Liao M., Klomp L.W.J., Lomri N., Berger R., Scharschmidt B.F., Knisely A.S., Houwen R.H.J., Freimer N.B.; "A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis."; Nat. Genet. 18:219-223(1998).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. DOI=10.1038/nature03983; PubMed=16177791 [NCBI, ExPASy, EBI, Israel, Japan] Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.; "DNA sequence and analysis of human chromosome 18."; Nature 437:551-555(2005).
[3]	NUCLEOTIDE SEQUENCE [MRNA] OF 388-661. TISSUE=Colon tumor; PubMed=9548971 [NCBI, ExPASy, EBI, Israel, Japan] Halleck M.S., Pradhan D., Blackman C.F., Berkes C., Williamson P.L., Schlegel R.A.; "Multiple members of a third subfamily of P-type ATPases identified by genomic sequences and ESTs."; Genome Res. 8:354-361(1998).
[4]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 359-1251, AND VARIANT THR-1152. TISSUE=Uterus; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[5]	VARIANT BRIC1 THR-661. DOI=10.1002/hep.510290214; PubMed=9918928 [NCBI, ExPASy, EBI, Israel, Japan] Tygstrup N., Steig B.A., Juijn J.A., Bull L.N., Houwen R.H.J.; "Recurrent familial intrahepatic cholestasis in the Faeroe Islands. Phenotypic heterogeneity but genetic homogeneity."; Hepatology 29:506-508(1999).
[6]	VARIANT PFIC1 ASN-554. DOI=10.1053/jhep.2000.20520; PubMed=11093741 [NCBI, ExPASy, EBI, Israel, Japan] Klomp L.W.J., Bull L.N., Knisely A.S., van Der Doelen M.A., Juijn J.A., Berger R., Forget S., Nielsen I.-M., Eiberg H., Houwen R.H.J.; "A missense mutation in FIC1 is associated with Greenland familial cholestasis."; Hepatology 32:1337-1341(2000).
[7]	VARIANTS PFIC1 PRO-127; TYR-403; PRO-412; MET-456; HIS-500; PHE-529 DEL; LEU-535; ASN-554; THR-661; GLY-688; ARG-733; SER-853; ARG-892 AND ARG-1040, VARIANTS BRIC1 ASN-70; ASP-308; PHE-344; TYR-453; GLY-454; TRP-600; GLN-600; TRP-628; THR-661; THR-694 AND ARG-892, AND VARIANT ALA-429. DOI=10.1002/hep.20285; PubMed=15239083 [NCBI, ExPASy, EBI, Israel, Japan] Klomp L.W.J., Vargas J.C., van Mil S.W.C., Pawlikowska L., Strautnieks S.S., van Eijk M.J.T., Juijn J.A., Pabon-Pena C., Smith L.B., DeYoung J.A., Byrne J.A., Gombert J., van der Brugge G., Berger R., Jankowska I., Pawlowska J., Villa E., Knisely A.S., Thompson R.J., Freimer N.B., Houwen R.H.J., Bull L.N.; "Characterization of mutations in ATP8B1 associated with hereditary cholestasis."; Hepatology 40:27-38(2004).
[8]	VARIANTS ICP THR-45 AND GLU-203, AND VARIANT GLN-952. DOI=10.1038/sj.ejhg.5201355; PubMed=15657619 [NCBI, ExPASy, EBI, Israel, Japan] Painter J.N., Savander M., Ropponen A., Nupponen N., Riikonen S., Ylikorkala O., Lehesjoki A.E., Aittomaki K.; "Sequence variation in the ATP8B1 gene and intrahepatic cholestasis of pregnancy."; Eur. J. Hum. Genet. 13:435-439(2005).
[9]	VARIANT ICP CYS-867, AND VARIANTS ASN-70; ILE-305 AND GLN-952. DOI=10.1136/gut.2004.058115; PubMed=15888793 [NCBI, ExPASy, EBI, Israel, Japan] Muellenbach R., Bennett A., Tetlow N., Patel N., Hamilton G., Cheng F., Chambers J., Howard R., Taylor-Robinson S.D., Williamson C.; "ATP8B1 mutations in British cases with intrahepatic cholestasis of pregnancy."; Gut 54:829-834(2005).
[10]	VARIANTS [LARGE SCALE ANALYSIS] VAL-886 AND MET-1178. DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan] Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.; "The consensus coding sequences of human breast and colorectal cancers."; Science 314:268-274(2006).

Comments

FUNCTION: May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both.
CATALYTIC ACTIVITY: ATP + H₂O + phospholipid(In) = ADP + phosphate + phospholipid(Out).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Found in most tissues except brain and skeletal muscle. Most abundant in pancreas and small intestine.
DISEASE: Defects in ATP8B1 are the cause of progressive familial intrahepatic cholestasis type 1 (PFIC1) [MIM:211600]; also known as Byler disease. PFIC1 is an autosomal recessive disorder, characterized by early infancy cholestasis, that may be initially episodic but progresses to malnutrition, growth retardation and end-stage liver disease before adulthood.
DISEASE: Defects in ATP8B1 are the cause of benign recurrent intrahepatic cholestasis type 1 (BRIC1) [MIM:243300]; also known as Summerskill syndrome. BRIC is characterized by intermittent episodes of cholestasis without progression to liver failure. There is initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The cholestatic attacks vary in severity and duration. Patients are asymptomatic between episodes, both clinically and biochemically.
DISEASE: Defects in ATP8B1 can be associated with intrahepatic cholestasis of pregnancy (ICP) [MIM:147480]; also known as pregnancy-related cholestasis. ICP is a multifactorial liver disorder of pregnancy. It presents during the second or, more commonly, the third trimestre of pregnancy with intense pruritus which becomes more severe with advancing gestation and cholestasis. Cholestasis results from abnormal biliary transport from the liver into the small intestine. ICP causes fetal distress, spontaneous premature delivery and intrauterine death. ICP patients have spontaneous and progressive disappearance of cholestasis after delivery.
SIMILARITY: Belongs to the cation transport ATPase (P-type) family. Type IV subfamily.
WEB RESOURCE: Name=GeneReviews; URL="http://www.genetests.org/query?gene=ATP8B1";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF038007; AAC63461.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AC027097; -; NOT_ANNOTATED_CDS; Genomic_DNA.	[EMBL / GenBank / DDBJ]
AF032442; AAC04328.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC003534; AAH03534.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00012851; -.

NP_005594.1; -.

3D structure databases

ModBase

O43520.

PTM databases

PhosphoSite

O43520; -.

Enzyme and pathway databases

BRENDA

3.6.3.1; 247.

Organism-specific databases

GC18M053466; -.

HGNC:3706; ATP8B1.

147480; phenotype. [NCBI / EBI]
211600; phenotype. [NCBI / EBI]
243300; phenotype. [NCBI / EBI]
602397; gene. [NCBI / EBI]

Orphanet

65682; Benign recurrent intrahepatic cholestasis.
172; Cholestasis, progressive familial intrahepatic.
79306; Cholestasis, progressive familial intrahepatic, type 1.
69665; Intrahepatic cholestasis of pregnancy.

PharmGKB

PA265; -.

Gene expression databases

O43520; -.

O43520; -.

HS_ATP8B1; -.

ENSG00000081923; Homo sapiens.

Ontologies

GO:0016324;	Cellular component: apical plasma membrane (inferred from direct assay from UniProtKB).
GO:0005887;	Cellular component: integral to plasma membrane (non-traceable author statement from UniProtKB).
GO:0005624;	Cellular component: membrane fraction (inferred from direct assay from UniProtKB).
GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from UniProtKB-KW).
GO:0015662;	Molecular function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism (inferred from electronic annotation from InterPro).
GO:0000287;	Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004012;	Molecular function: phospholipid-translocating ATPase activity (traceable author statement from UniProtKB).
GO:0006754;	Biological process: ATP biosynthetic process (inferred from electronic annotation from InterPro).
GO:0015721;	Biological process: bile acid and bile salt transport (non-traceable author statement from UniProtKB).
GO:0016481;	Biological process: negative regulation of transcription (inferred from mutant phenotype from UniProtKB).
GO:0015914;	Biological process: phospholipid transport (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR008250; ATPase_P-typ_ATPase-assoc-reg.
IPR001757; ATPase_P-typ_ion-transptr.
IPR018303; ATPase_P-typ_phosphor_site.
IPR006539; ATPase_P-typ_Plipid-transl.
Graphical view of domain structure.

PANTHER

PTHR11939; ATPase_P; 1.

Pfam

PF00122; E1-E2_ATPase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00119; CATATPASE.

TIGRFAMs

TIGR01652; ATPase-Plipid; 1.
TIGR01494; ATPase_P-type; 4.

PROSITE

PS00154; ATPASE_E1_E2; 1.

Proteomic databases

PRIDE

O43520; -.

Genome annotation databases

Ensembl

ENSG00000081923; Homo sapiens. [Contig view]

GeneID

5205; -.

KEGG

hsa:5205; -.

Phylogenomic databases

HOGENOM

O43520; -.

HOVERGEN

O43520; -.

Other

NextBio

20132; -.

SOURCE

ATP8B1; Homo sapiens.

ProtoNet

O43520.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Disease mutation; Hydrolase; Intrahepatic cholestasis; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 1251`	`1251`	`Probable phospholipid-transporting ATPase IC.`	`PRO_0000046364`
`TOPO_DOM`	`1 108`	`108`	`Cytoplasmic (Potential).`
`TRANSMEM`	`109 130`	`22`	`Potential.`
`TOPO_DOM`	`131 136`	`6`	`Extracellular (Potential).`
`TRANSMEM`	`137 156`	`20`	`Potential.`
`TOPO_DOM`	`157 340`	`184`	`Cytoplasmic (Potential).`
`TRANSMEM`	`341 362`	`22`	`Potential.`
`TOPO_DOM`	`363 389`	`27`	`Extracellular (Potential).`
`TRANSMEM`	`390 411`	`22`	`Potential.`
`TOPO_DOM`	`412 949`	`538`	`Cytoplasmic (Potential).`
`TRANSMEM`	`950 970`	`21`	`Potential.`
`TOPO_DOM`	`971 982`	`12`	`Extracellular (Potential).`
`TRANSMEM`	`983 1002`	`20`	`Potential.`
`TOPO_DOM`	`1003 1032`	`30`	`Cytoplasmic (Potential).`
`TRANSMEM`	`1033 1054`	`22`	`Potential.`
`TOPO_DOM`	`1055 1068`	`14`	`Extracellular (Potential).`
`TRANSMEM`	`1069 1091`	`23`	`Potential.`
`TOPO_DOM`	`1092 1097`	`6`	`Cytoplasmic (Potential).`
`TRANSMEM`	`1098 1118`	`21`	`Potential.`
`TOPO_DOM`	`1119 1138`	`20`	`Extracellular (Potential).`
`TRANSMEM`	`1139 1163`	`25`	`Potential.`
`TOPO_DOM`	`1164 1251`	`88`	`Cytoplasmic (Potential).`
`ACT_SITE`	`454 454`		`4-aspartylphosphate intermediate (By similarity).`
`METAL`	`893 893`		`Magnesium (By similarity).`
`METAL`	`897 897`		`Magnesium (By similarity).`
`VARIANT`	`45 45`	`1`	`N -> T (in ICP).`	`VAR_043044`
`VARIANT`	`70 70`	`1`	`D -> N (in BRIC1; compound heterozygote with Q-600; uncertain pathological significance; may be associated with ICP; dbSNP:rs34719006 [NCBI]).`	`VAR_043045`
`VARIANT`	`78 78`	`1`	`H -> Q (in dbSNP:rs3745079 [NCBI]).`	`VAR_029271`
`VARIANT`	`127 127`	`1`	`L -> P (in PFIC1).`	`VAR_043046`
`VARIANT`	`203 203`	`1`	`K -> E (in ICP).`	`VAR_043047`
`VARIANT`	`288 288`	`1`	`L -> S (in PFIC1).`	`VAR_008809`
`VARIANT`	`305 305`	`1`	`F -> I.`	`VAR_043048`
`VARIANT`	`308 308`	`1`	`G -> D (in BRIC1; dbSNP:rs28939685 [NCBI]).`	`VAR_043049`
`VARIANT`	`308 308`	`1`	`G -> V (in PFIC1).`	`VAR_008810`
`VARIANT`	`344 344`	`1`	`I -> F (in BRIC1).`	`VAR_043050`
`VARIANT`	`384 384`	`1`	`R -> H (in dbSNP:rs2271260 [NCBI]).`	`VAR_043051`
`VARIANT`	`393 393`	`1`	`I -> V (in dbSNP:rs34315917 [NCBI]).`	`VAR_043052`
`VARIANT`	`403 403`	`1`	`S -> Y (in PFIC1).`	`VAR_043053`
`VARIANT`	`412 412`	`1`	`R -> P (in PFIC1).`	`VAR_043054`
`VARIANT`	`429 429`	`1`	`E -> A (in dbSNP:rs34018205 [NCBI]).`	`VAR_043055`
`VARIANT`	`453 453`	`1`	`S -> Y (in BRIC1).`	`VAR_043056`
`VARIANT`	`454 454`	`1`	`D -> G (in BRIC1).`	`VAR_043057`
`VARIANT`	`456 456`	`1`	`T -> M (in PFIC1).`	`VAR_043058`
`VARIANT`	`500 500`	`1`	`Y -> H (in PFIC1).`	`VAR_043059`
`VARIANT`	`529 529`	`1`	`Missing (in PFIC1).`	`VAR_043060`
`VARIANT`	`535 535`	`1`	`H -> L (in PFIC1).`	`VAR_043061`
`VARIANT`	`554 554`	`1`	`D -> N (in PFIC1).`	`VAR_015423`
`VARIANT`	`577 577`	`1`	`I -> V (in dbSNP:rs3745078 [NCBI]).`	`VAR_029272`
`VARIANT`	`580 580`	`1`	`S -> N (in dbSNP:rs33963153 [NCBI]).`	`VAR_043062`
`VARIANT`	`600 600`	`1`	`R -> Q (in BRIC1; compound heterozygote with N-70).`	`VAR_043063`
`VARIANT`	`600 600`	`1`	`R -> W (in BRIC1).`	`VAR_043064`
`VARIANT`	`628 628`	`1`	`R -> W (in BRIC1).`	`VAR_043065`
`VARIANT`	`645 699`	`55`	`Missing (in PFIC1).`	`VAR_008811`
`VARIANT`	`661 661`	`1`	`I -> T (in BRIC1 and PFIC1; common mutation).`	`VAR_008812`
`VARIANT`	`674 674`	`1`	`M -> T (in dbSNP:rs35470719 [NCBI]).`	`VAR_043066`
`VARIANT`	`688 688`	`1`	`D -> G (in PFIC1).`	`VAR_043067`
`VARIANT`	`694 694`	`1`	`I -> T (in BRIC1).`	`VAR_043068`
`VARIANT`	`733 733`	`1`	`G -> R (in PFIC1).`	`VAR_043069`
`VARIANT`	`795 797`	`3`	`Missing (in BRIC1).`	`VAR_008814`
`VARIANT`	`814 814`	`1`	`K -> N (in dbSNP:rs34018300 [NCBI]).`	`VAR_043070`
`VARIANT`	`853 853`	`1`	`F -> S (in PFIC1).`	`VAR_043071`
`VARIANT`	`867 867`	`1`	`R -> C (in ICP).`	`VAR_043072`
`VARIANT`	`886 886`	`1`	`A -> V (in a breast cancer sample; somatic mutation).`	`VAR_036499`
`VARIANT`	`892 892`	`1`	`G -> R (in PFIC1 and BRIC1).`	`VAR_008813`
`VARIANT`	`952 952`	`1`	`R -> Q (in dbSNP:rs12968116 [NCBI]).`	`VAR_029273`
`VARIANT`	`1040 1040`	`1`	`G -> R (in PFIC1).`	`VAR_043073`
`VARIANT`	`1152 1152`	`1`	`A -> T (in dbSNP:rs222581 [NCBI]).`	`VAR_055045`
`VARIANT`	`1178 1178`	`1`	`I -> M (in a breast cancer sample; somatic mutation).`	`VAR_036500`
`CONFLICT`	`1016 1016`		`P -> L (in Ref. 4; AAH03534).`

Sequence information

Length: 1251 AA [This is the length of the unprocessed precursor]

Molecular weight: 143695 Da [This is the MW of the unprocessed precursor]

CRC64: 770FEF3946CB579F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSTERDSETT FDEDSQPNDE VVPYSDDETE DELDDQGSAV EPEQNRVNRE AEENREPFRK 

        70         80         90        100        110        120 
ECTWQVKAND RKYHEQPHFM NTKFLCIKES KYANNAIKTY KYNAFTFIPM NLFEQFKRAA 

       130        140        150        160        170        180 
NLYFLALLIL QAVPQISTLA WYTTLVPLLV VLGVTAIKDL VDDVARHKMD KEINNRTCEV 

       190        200        210        220        230        240 
IKDGRFKVAK WKEIQVGDVI RLKKNDFVPA DILLLSSSEP NSLCYVETAE LDGETNLKFK 

       250        260        270        280        290        300 
MSLEITDQYL QREDTLATFD GFIECEEPNN RLDKFTGTLF WRNTSFPLDA DKILLRGCVI 

       310        320        330        340        350        360 
RNTDFCHGLV IFAGADTKIM KNSGKTRFKR TKIDYLMNYM VYTIFVVLIL LSAGLAIGHA 

       370        380        390        400        410        420 
YWEAQVGNSS WYLYDGEDDT PSYRGFLIFW GYIIVLNTMV PISLYVSVEV IRLGQSHFIN 

       430        440        450        460        470        480 
WDLQMYYAEK DTPAKARTTT LNEQLGQIHY IFSDKTGTLT QNIMTFKKCC INGQIYGDHR 

       490        500        510        520        530        540 
DASQHNHNKI EQVDFSWNTY ADGKLAFYDH YLIEQIQSGK EPEVRQFFFL LAVCHTVMVD 

       550        560        570        580        590        600 
RTDGQLNYQA ASPDEGALVN AARNFGFAFL ARTQNTITIS ELGTERTYNV LAILDFNSDR 

       610        620        630        640        650        660 
KRMSIIVRTP EGNIKLYCKG ADTVIYERLH RMNPTKQETQ DALDIFANET LRTLCLCYKE 

       670        680        690        700        710        720 
IEEKEFTEWN KKFMAASVAS TNRDEALDKV YEEIEKDLIL LGATAIEDKL QDGVPETISK 

       730        740        750        760        770        780 
LAKADIKIWV LTGDKKETAE NIGFACELLT EDTTICYGED INSLLHARME NQRNRGGVYA 

       790        800        810        820        830        840 
KFAPPVQESF FPPGGNRALI ITGSWLNEIL LEKKTKRNKI LKLKFPRTEE ERRMRTQSKR 

       850        860        870        880        890        900 
RLEAKKEQRQ KNFVDLACEC SAVICCRVTP KQKAMVVDLV KRYKKAITLA IGDGANDVNM 

       910        920        930        940        950        960 
IKTAHIGVGI SGQEGMQAVM SSDYSFAQFR YLQRLLLVHG RWSYIRMCKF LRYFFYKNFA 

       970        980        990       1000       1010       1020 
FTLVHFWYSF FNGYSAQTAY EDWFITLYNV LYTSLPVLLM GLLDQDVSDK LSLRFPGLYI 

      1030       1040       1050       1060       1070       1080 
VGQRDLLFNY KRFFVSLLHG VLTSMILFFI PLGAYLQTVG QDGEAPSDYQ SFAVTIASAL 

      1090       1100       1110       1120       1130       1140 
VITVNFQIGL DTSYWTFVNA FSIFGSIALY FGIMFDFHSA GIHVLFPSAF QFTGTASNAL 

      1150       1160       1170       1180       1190       1200 
RQPYIWLTII LAVAVCLLPV VAIRFLSMTI WPSESDKIQK HRKRLKAEEQ WQRRQQVFRR 

      1210       1220       1230       1240       1250 
GVSTRRSAYA FSHQRGYADL ISSGRSIRKK RSPLDAIVAD GTAEYRRTGD S

O43520 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools