ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry O43251


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name RBM9_HUMAN
Primary accession number O43251
Secondary accession numbers A4F5G8 A8K5Z5 Q0PRL5 Q0VH35 Q5TF71 Q6IC09 Q8TD00 Q8WYB1 Q96DZ6 Q96NL7 Q9UGW4 Q9UH33
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on April 11, 2003 (Sequence version 3)
Annotations were last modified on    September 2, 2008 (Entry version 84)
Name and origin of the protein
Protein name RNA-binding protein 9
Synonyms RNA-binding motif protein 9
Fox-1 homolog B
Hexaribonucleotide-binding protein 2
Repressor of tamoxifen transcriptional activity
Gene name
Name: RBM9
Synonyms: FOX2, HRNBP2, RTA
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
DOI=10.1210/me.16.3.459; PubMed=11875103 [NCBI, ExPASy, EBI, Israel, Japan]
Norris J.D., Fan D., Sherk A., McDonnell D.P.;
"A negative coregulator for the human ER.";
Mol. Endocrinol. 16:459-468(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
TISSUE=Placenta;
DOI=10.1101/gr.695703; PubMed=12529303 [NCBI, ExPASy, EBI, Israel, Japan]
Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I.;
"Reevaluating human gene annotation: a second-generation analysis of chromosome 22.";
Genome Res. 13:27-36(2003).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Chen W., Winkelmann J.C.;
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 6).
TISSUE=Brain;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
DOI=10.1186/gb-2004-5-10-r84; PubMed=15461802 [NCBI, ExPASy, EBI, Israel, Japan]
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.;
"A genome annotation-driven approach to cloning the human ORFeome.";
Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).
[6]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
Yang G., Huang S.C., Benz E.J. Jr.;
"A novel isoform of RNA binding motif protein 9.";
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8).
Zhou G., Nong W., Li H., Ke R., Shen C., Liang M., Tang Z., Huang B., Lin L., Yang S.;
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/990031; PubMed=10591208 [NCBI, ExPASy, EBI, Israel, Japan]
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.;
"The DNA sequence of human chromosome 22.";
Nature 402:489-495(1999).
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
TISSUE=Adrenal gland, and Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[10]
NUCLEOTIDE SEQUENCE [MRNA] OF 3-371 (ISOFORM 7).
Papin C.;
"XRbm9, a new XGld2-interacting protein, enhances translation in Xenopus oocytes.";
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
[11]
STRUCTURE BY NMR OF 113-202.
RIKEN structural genomics initiative (RSGI);
"Solution structure of RNA binding domain in RNA binding motif protein 9.";
Submitted (NOV-2005) to the PDB data bank.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY072786; AAL67150.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL009266; CAA15842.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF229058; AAL71905.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK055213; BAB70875.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK291460; BAF84149.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR456559; CAG30445.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY960684; AAX84843.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
DQ778625; ABG77459.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL049748; CAI20525.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL079295; CAI20525.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL079295; CAI19059.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL049748; CAI19059.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC013115; AAH13115.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC025281; AAH25281.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AM419009; CAL91352.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001026865.1; -.
NP_001076045.1; -.
NP_001076046.1; -.
NP_001076047.1; -.
NP_001076048.1; -.
NP_055124.1; -.
UniGene Hs.282998
3D structure databases
PDB
2CQ3; NMR; -; A=113-202.[ExPASy / RCSB / EBI]
PDBsum 2CQ3; -.
ModBase O43251.
Protein-protein interaction databases
IntAct O43251; -.
Organism-specific databases
H-InvDB HIX0016419; -.
HGNC HGNC:9906; RBM9.
GenAtlas RBM9.
HPA HPA006240; -.
PharmGKB PA34272; -.
GeneCards O43251.
Gene expression databases
ArrayExpress O43251; -.
CleanEx HS_RBM9; -.
GermOnline ENSG00000100320; Homo sapiens.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from direct assay from UniProtKB).
GO:0003723; Molecular function: RNA binding (inferred from direct assay from UniProtKB).
GO:0003714; Molecular function: transcription corepressor activity (inferred from direct assay from UniProtKB).
GO:0030520; Biological process: estrogen receptor signaling pathway (inferred from direct assay from UniProtKB).
GO:0016481; Biological process: negative regulation of transcription (inferred from direct assay from UniProtKB).
GO:0042127; Biological process: regulation of cell proliferation (traceable author statement from UniProtKB).
GO:0016070; Biological process: RNA metabolic process (traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR012677; a_b_plait_nuc_bd.
IPR017325; RNA-bd_9/Ataxin-2-bd.
IPR000504; RRM_RNP1.
Graphical view of domain structure.
Gene3D G3DSA:3.30.70.330; a_b_plait_nuc_bd; 1.
Pfam PF00076; RRM_1; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF037932; Ataxin_2_bd_A2BP; 1.
SMART SM00360; RRM; 1.
SMART graphical view of domain structure.
PROSITE PS50102; RRM; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS O43251.
Genome annotation databases
Ensembl ENSG00000100320; Homo sapiens. [Contig view]
GeneID 23543; -.
KEGG hsa:23543; -.
Phylogenomic databases
HOVERGEN O43251; -.
Other
ProtoNet O43251.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative splicing; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; RNA-binding.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   390  390     RNA-binding protein 9. PRO_0000081766
DOMAIN   121   197  77     RRM. 
COMPBIAS   273   377  105     Ala-rich. 
SITE   122   122  1     Interaction with RNA (By similarity). 
SITE   130   130  1     Interaction with RNA (By similarity). 
SITE   131   131  1     Interaction with RNA (By similarity). 
SITE   155   155  1     Interaction with RNA (By similarity). 
SITE   160   160  1     Interaction with RNA (By similarity). 
SITE   164   164  1     Interaction with RNA (By similarity). 
SITE   188   188  1     Interaction with RNA (By similarity). 
SITE   198   198  1     Interaction with RNA (By similarity). 
VAR_SEQ   1    18        MQNEPLTPGYHGFPARDS -> MEKKKMVT (in isoform 2, isoform 3, isoform 4 and isoform 5). VSP_007180
VAR_SEQ   1     1        M -> MAEGAQPQQPPQLGPGAAARGMKRESELELPVPGAGGDGA DPGLSKRPRTEEAAADGGGGM (in isoform 6 and isoform 8). VSP_030889
VAR_SEQ   94    94        T -> TQ (in isoform 2 and isoform 8). VSP_030890
VAR_SEQ   143   160        Missing (in isoform 3). VSP_007181
VAR_SEQ   261   265        SLPLV -> I (in isoform 3, isoform 5 and isoform 7). VSP_007182
VAR_SEQ   311   390        VYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYS DGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY -> DMQPTDMHSLLLQPQPPLLQPLQPLTVTVMAGCTQPTPTM PLPLPLAMELALWRVYTEVATADLPPTEVT (in isoform 4). VSP_007183
VAR_SEQ   323   390        GGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPY HALAPAASYGVGAVASLYRGGYSRFAPY -> IESANCFRSNRVDMQPTDMHSLLLQPQPPLLQPLQPLTVT VMAGCTQPTPTMPLPLPLAMELALWRVYTEVATADLP PTEVT (in isoform 7). VSP_030891
CONFLICT   116   116        S -> G (in Ref. 6; AAX84843). 
CONFLICT   231   231        S -> F (in Ref. 4; BAB70875). 
CONFLICT   346   346        A -> V (in Ref. 8; AAH13115). 
CONFLICT   350   350        S -> G (in Ref. 4; BAB70875). 
STRAND   122   127  6      
HELIX   134   140  7      
HELIX   141   143  3      
STRAND   147   153  7      
TURN   156   159  4      
STRAND   162   168  7      
HELIX   170   180  11      
STRAND   191   194  4      
Sequence information
Length: 390 AA [This is the length of the unprocessed precursor] Molecular weight: 41374 Da [This is the MW of the unprocessed precursor] CRC64: 40D6C8C40764B317 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MQNEPLTPGY HGFPARDSQG NQEPTTTPDA MVQPFTTIPF PPPPQNGIPT EYGVPHTQDY 

        70         80         90        100        110        120 
AGQTGEHNLT LYGSTQAHGE QSSNSPSTQN GSLTTEGGAQ TDGQQSQTQS SENSESKSTP 

       130        140        150        160        170        180 
KRLHVSNIPF RFRDPDLRQM FGQFGKILDV EIIFNERGSK GFGFVTFENS ADADRAREKL 

       190        200        210        220        230        240 
HGTVVEGRKI EVNNATARVM TNKKMVTPYA NGWKLSPVVG AVYGPELYAA SSFQADVSLG 

       250        260        270        280        290        300 
NDAAVPLSGR GGINTYIPLI SLPLVPGFPY PTAATTAAAF RGAHLRGRGR TVYGAVRAVP 

       310        320        330        340        350        360 
PTAIPAYPGV VYQDGFYGAD LYGGYAAYRY AQPATATAAT AAAAAAAAYS DGYGRVYTAD 

       370        380        390 
PYHALAPAAS YGVGAVASLY RGGYSRFAPY 

O43251 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!