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UniProtKB/Swiss-Prot entry O35827

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name APBB3_RAT
Primary accession number O35827
Secondary accession numbers None
Integrated into Swiss-Prot on January 11, 2001
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    June 10, 2008 (Entry version 47)
Name and origin of the protein
Protein name Amyloid beta A4 precursor protein-binding family B member 3
Synonyms Fe65-like protein 2
Fe65L2
Gene name
Name: Apbb3
Synonyms: Fe65l2
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9461550 [NCBI, ExPASy, EBI, Israel, Japan]
Duilio A., Faraonio R., Minopoli G., Zambrano N., Russo T.;
"Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein.";
Biochem. J. 330:513-519(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Y13413; CAA73837.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_446409.1; -.
UniGene Rn.30067
3D structure databases
ModBase O35827.
Protein-protein interaction databases
IntAct O35827; -.
Organism-specific databases
RGD 620853; Apbb3.
GeneLynx Apbb3; Rattus norvegicus.
Gene expression databases
ArrayExpress O35827; -.
GermOnline ENSRNOG00000017849; Rattus norvegicus.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR011993; PH_type.
IPR006020; PTB_PID.
IPR001202; WW_Rsp5_WWP.
Graphical view of domain structure.
Gene3D G3DSA:2.30.29.30; PH_type; 1.
Pfam PF00640; PID; 2.
PF00397; WW; 1.
Pfam graphical view of domain structure.
SMART SM00462; PTB; 2.
SM00456; WW; 1.
SMART graphical view of domain structure.
PROSITE PS01179; PID; 2.
PS01159; WW_DOMAIN_1; 1.
PS50020; WW_DOMAIN_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS O35827.
Genome annotation databases
Ensembl ENSRNOG00000017849; Rattus norvegicus. [Contig view]
GeneID 117026; -.
KEGG rno:117026; -.
Phylogenomic databases
HOVERGEN O35827; -.
Other
ProtoNet O35827.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   504  504     Amyloid beta A4 precursor protein-binding family B member 3. PRO_0000076056
DOMAIN   29    61  33     WW. 
DOMAIN   111   278  168     PID 1. 
DOMAIN   283   438  156     PID 2. 
Sequence information
Length: 504 AA [This is the length of the unprocessed precursor] Molecular weight: 54907 Da [This is the MW of the unprocessed precursor] CRC64: A49CA9E99BDB3A3A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLGKDYMLAI ILVNCDDDLW GDQNLEGETG LPPGWRKIRD AAGTYYWHVP SGSTQWQRPT 

        70         80         90        100        110        120 
WELAEDPGTG KEGIWELRPP KGRSFSSLDS SLNRSNSLTW YNEDSYVRSL EPGAKCFAVR 

       130        140        150        160        170        180 
SLGWVEVPEE DLAPGKSSIA VNNCIQQLAQ ARNRSQPHDG AWGEGQNMLM VLKKDAMSLL 

       190        200        210        220        230        240 
NPLDHSLIHC QPLVHIRVWG VGSSKGRDRD FAFVAGDKDS CMLKCHVFRC DVPAKAIASR 

       250        260        270        280        290        300 
LQGLCAQILS ERVGLSGEAA CCSPDPISPE DFPRQVELLD AVSQAAQKYE ALYMGILPVT 

       310        320        330        340        350        360 
KAMGMDVLNE AIGTLTGRGD RKTWVPAMLS VSDSLMTAHP IQAEAGAEEE PLWQCPVRLV 

       370        380        390        400        410        420 
TFIGVGHDPH TFGLIADLGC QSFQCAAFWC QPHAGGLSEA VQAACMVQYQ KCLVASAARG 

       430        440        450        460        470        480 
KAWGAQARAR LRLKRTSSMD SPGGPLPPPL LKGGVGGAGA APRKRGVFSF LDAFRLKPLF 

       490        500 
SICPKLILEG WGKRLYTLPV PRVL
O35827 in FASTA format

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