ID   BMPR2_MOUSE             Reviewed;        1038 AA.
AC   O35607;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   22-JUL-2008, entry version 77.
DE   RecName: Full=Bone morphogenetic protein receptor type-2;
DE            EC=2.7.11.30;
DE   AltName: Full=Bone morphogenetic protein receptor type II;
DE   AltName: Full=BMP type II receptor;
DE   AltName: Full=BMPR-II;
DE   AltName: Full=BRK-3;
DE   Flags: Precursor;
GN   Name=Bmpr2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=97350808; PubMed=9207184; DOI=10.1006/bbrc.1997.6816;
RA   Beppu H., Minowa O., Miyazono K., Kawabata M.;
RT   "cDNA cloning and genomic organization of the mouse BMP type II
RT   receptor.";
RL   Biochem. Biophys. Res. Commun. 235:499-504(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Whitaker G.B., Koenig B.B., Ting J., Tiesman J.P., Limberg A.L.,
RA   Grant R.A., Begley K.B., Rosenbaum J.S.;
RT   "Identification of BMP receptor complexes with differential signaling
RT   properties and ligand binding profiles.";
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: On ligand binding, forms a receptor complex consisting
CC       of two type II and two type I transmembrane serine/threonine
CC       kinases. Type II receptors phosphorylate and activate type I
CC       receptors which autophosphorylate, then bind and activate SMAD
CC       transcriptional regulators. Binds to BMP-7, BMP-2 and, less
CC       efficiently, BMP-4. Binding is weak but enhanced by the presence
CC       of type I receptors for BMPs.
CC   -!- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-
CC       protein] phosphate.
CC   -!- COFACTOR: Magnesium or manganese (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; AF003942; AAB63042.1; -; mRNA.
DR   EMBL; U78048; AAB87638.1; -; mRNA.
DR   PIR; JC5527; JC5527.
DR   RefSeq; NP_031587.1; -.
DR   UniGene; Mm.391654; -.
DR   UniGene; Mm.466857; -.
DR   HSSP; P36897; 1IAS.
DR   SMR; O35607; 33-131.
DR   IntAct; O35607; -.
DR   PhosphoSite; O35607; -.
DR   Ensembl; ENSMUSG00000067336; Mus musculus.
DR   GeneID; 12168; -.
DR   KEGG; mmu:12168; -.
DR   MGI; MGI:1095407; Bmpr2.
DR   HOGENOM; O35607; -.
DR   HOVERGEN; O35607; -.
DR   ArrayExpress; O35607; -.
DR   GermOnline; ENSMUSG00000067336; Mus musculus.
DR   GO; GO:0009986; C:cell surface; IDA:MGI.
DR   GO; GO:0048286; P:alveolus development; IMP:UniProtKB.
DR   GO; GO:0009952; P:anterior/posterior pattern formation; IMP:MGI.
DR   GO; GO:0030509; P:BMP signaling pathway; IMP:MGI.
DR   GO; GO:0001707; P:mesoderm formation; IMP:MGI.
DR   GO; GO:0045906; P:negative regulation of vasoconstriction; IMP:UniProtKB.
DR   GO; GO:0014916; P:regulation of lung blood pressure; IMP:UniProtKB.
DR   GO; GO:0048010; P:vascular endothelial growth factor receptor...; IMP:UniProtKB.
DR   InterPro; IPR000472; Activin_rcpt.
DR   InterPro; IPR015770; BMPRII.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_bd_CS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   PANTHER; PTHR23255:SF12; BMPRII; 1.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; FALSE_NEG.
PE   2: Evidence at transcript level;
KW   ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane;
KW   Metal-binding; Nucleotide-binding; Receptor;
KW   Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
FT   SIGNAL        1     26       Potential.
FT   CHAIN        27   1038       Bone morphogenetic protein receptor type-
FT                                2.
FT                                /FTId=PRO_0000024416.
FT   TOPO_DOM     27    150       Extracellular (Potential).
FT   TRANSMEM    151    171       Potential.
FT   TOPO_DOM    172   1038       Cytoplasmic (Potential).
FT   DOMAIN      203    504       Protein kinase.
FT   NP_BIND     209    217       ATP (By similarity).
FT   COMPBIAS    191    194       Poly-Ala.
FT   COMPBIAS    547    550       Poly-Ser.
FT   COMPBIAS    610    618       Poly-Thr.
FT   COMPBIAS    901    908       Poly-Asn.
FT   ACT_SITE    333    333       Proton acceptor (By similarity).
FT   BINDING     230    230       ATP (By similarity).
FT   CARBOHYD     55     55       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    126    126       N-linked (GlcNAc...) (Potential).
FT   DISULFID     34     66       By similarity.
FT   DISULFID     94    117       By similarity.
SQ   SEQUENCE   1038 AA;  115020 MW;  4106945DC63250E1 CRC64;
     MTSSLHRPFR VPWLLWAVLL VSTTAASQNQ ERLCAFKDPY QQDLGIGESR ISHENGTILC
     SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHYEECV VTTTPPSIQN GTYRFCCCST
     DLCNVNFTEN FPPPDTTPLS PPHSFNRDET IIIALASVSV LAVLIVALCF GYRMLTGDRK
     QGLHSMNMME AAAAEPSLDL DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF
     INEKNIYRVP LMEHDNIARF IVGDERLTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS
     SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGACVIS DFGLSMRLTG
     NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA LKQVDMYALG LIYWEVFMRC
     TDLFPGESVP DYQMAFQTEV GNHPTFEDMQ VLVSREKQRP KFPEAWKENS LAVRSLKETI
     EDCWDQDAEA RLTAQCAEER MAELMMIWER NKSVSPTVNP MSTAMQNERN LSHNRRVPKI
     GPYPDYSSSS YIEDSIHHTD SIVKNISSEH SMSSTPLTIG EKNRNSINYE RQQAQARIPS
     PETSVTSLST NTTTTNTTGL TPSTGMTTIS EMPYPDETHL HATNVAQSIG PTPVCLQLTE
     EDLETNKLDP KEVDKNLKES SDENLMEHSL KQFSGPDPLS STSSSLLYPL IKLAVEVTGQ
     QDFTQAANGQ ACLIPDVPPA QIYPLPKQQN LPKRPTSLPL NTKNSTKEPR LKFGNKHKSN
     LKQVETGVAK MNTINAAEPH VVTVTMNGVA GRSHNVNSHA ATTQYANGAV PAGQAANIVA
     HRSQEMLQNQ FIGEDTRLNI NSSPDEHEPL LRREQQAGHD EGVLDRLVDR RERPLEGGRT
     NSNNNNSNPC SEQDILTQGV TSTAADPGPS KPRRAQRPNS LDLSATNILD GSSIQIGEST
     QDGKSGSGEK IKRRVKTPYS LKRWRPSTWV ISTEPLDCEV NNNGSDRAVH SKSSTAVYLA
     EGGTATTTVS KDIGMNCL
//