[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND TISSUE SPECIFICITY.
TISSUE=Spinal ganglion;
DOI=10.1038/39807; PubMed=9349813 [NCBI, ExPASy, EBI, Israel, Japan]
Caterina M.J.,
Schumacher M.A.,
Tominaga M.,
Rosen T.A.,
Levine J.D.,
Julius D.;
"The capsaicin receptor: a heat-activated ion channel in the pain pathway.";
Nature 389:816-824(1997).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, AND FUNCTION (ISOFORM 3).
STRAIN=Sprague-Dawley;
TISSUE=Spinal ganglion, and Trigeminal ganglion;
DOI=10.1074/jbc.275.4.2756; PubMed=10644739 [NCBI, ExPASy, EBI, Israel, Japan]
Schumacher M.A.,
Moff I.,
Sudanagunta S.P.,
Levine J.D.;
"Molecular cloning of an N-terminal splice variant of the capsaicin receptor. Loss of N-terminal domain suggests functional divergence among capsaicin receptor subtypes.";
J. Biol. Chem. 275:2756-2762(2000).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
DOI=10.1016/S0304-3940(01)02185-1; PubMed=11578842 [NCBI, ExPASy, EBI, Israel, Japan]
Tsutsumi S.,
Tomioka A.,
Sudo M.,
Nakamura A.,
Shirakura K.,
Takagishi K.,
Kohama K.;
"Propofol activates vanilloid receptor channels expressed in human embryonic kidney 293 cells.";
Neurosci. Lett. 312:45-49(2001).
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[4]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-468, AND ALTERNATIVE SPLICING.
STRAIN=Sprague-Dawley;
DOI=10.1006/geno.2001.6582; PubMed=11549313 [NCBI, ExPASy, EBI, Israel, Japan]
Xue Q.,
Yu Y.,
Trilk S.L.,
Jong B.E.,
Schumacher M.A.;
"The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants.";
Genomics 76:14-20(2001).
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[5]
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CHARACTERIZATION OF CHANNEL PORE, AND MUTAGENESIS OF GLU-636; LYS-639; MET-644; ASP-646; GLU-648 AND GLU-651.
DOI=10.1074/jbc.M002391200; PubMed=10931826 [NCBI, ExPASy, EBI, Israel, Japan]
Garcia-Martinez C.,
Morenilla-Palao C.,
Planells-Cases R.,
Merino J.M.,
Ferrer-Montiel A.V.;
"Identification of an aspartic residue in the P-loop of the vanilloid receptor that modulates pore properties.";
J. Biol. Chem. 275:32552-32558(2000).
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[6]
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FUNCTION.
DOI=10.1038/35050121; PubMed=11140687 [NCBI, ExPASy, EBI, Israel, Japan]
Premkumar L.S.,
Ahern G.P.;
"Induction of vanilloid receptor channel activity by protein kinase C.";
Nature 408:985-990(2000).
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[7]
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SUBCELLULAR LOCATION, AND GLYCOSYLATION AT ASN-604.
PubMed=11683872 [NCBI, ExPASy, EBI, Israel, Japan]
Jahnel R.,
Dreger M.,
Gillen C.,
Bender O.,
Kurreck J.,
Hucho F.;
"Biochemical characterization of the vanilloid receptor 1 expressed in a dorsal root ganglia derived cell line.";
Eur. J. Biochem. 268:5489-5496(2001).
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[8]
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FUNCTION, AND INTERACTION WITH PRKCG AND NTRK1.
DOI=10.1038/35082088; PubMed=11418861 [NCBI, ExPASy, EBI, Israel, Japan]
Chuang H.H.,
Prescott E.D.,
Kong H.,
Shields S.,
Jordt S.E.,
Basbaum A.I.,
Chao M.V.,
Julius D.;
"Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition.";
Nature 411:957-962(2001).
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[9]
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PHOSPHORYLATION AT SER-502 AND SER-800, AND MUTAGENESIS OF SER-502 AND SER-800.
DOI=10.1074/jbc.C200104200; PubMed=11884385 [NCBI, ExPASy, EBI, Israel, Japan]
Numazaki M.,
Tominaga T.,
Toyooka H.,
Tominaga M.;
"Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues.";
J. Biol. Chem. 277:13375-13378(2002).
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[10]
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FUNCTION.
DOI=10.1074/jbc.M201551200; PubMed=12095983 [NCBI, ExPASy, EBI, Israel, Japan]
Olah Z.,
Karai L.,
Iadarola M.J.;
"Protein kinase C(alpha) is required for vanilloid receptor 1 activation. Evidence for multiple signaling pathways.";
J. Biol. Chem. 277:35752-35759(2002).
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[11]
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FUNCTION, AND PHOSPHORYLATION AT SER-116; THR-144; THR-370; SER-502; SER-774 AND SER-820.
DOI=10.1016/S0896-6273(02)00802-4; PubMed=12194871 [NCBI, ExPASy, EBI, Israel, Japan]
Bhave G.,
Zhu W.,
Wang H.,
Brasier D.J.,
Oxford G.S.,
Gereau R.W. IV;
"cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation.";
Neuron 35:721-731(2002).
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[12]
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FUNCTION, AND INTERACTION WITH CALMODULIN.
DOI=10.1073/pnas.1337252100; PubMed=12808128 [NCBI, ExPASy, EBI, Israel, Japan]
Numazaki M.,
Tominaga T.,
Takeuchi K.,
Murayama N.,
Toyooka H.,
Tominaga M.;
"Structural determinant of TRPV1 desensitization interacts with calmodulin.";
Proc. Natl. Acad. Sci. U.S.A. 100:8002-8006(2003).
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[13]
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FUNCTION, AND MUTAGENESIS OF SER-502; THR-704 AND SER-800.
DOI=10.1073/pnas.2032100100; PubMed=14523239 [NCBI, ExPASy, EBI, Israel, Japan]
Bhave G.,
Hu H.J.,
Glauner K.S.,
Zhu W.,
Wang H.,
Brasier D.J.,
Oxford G.S.,
Gereau R.W. IV;
"Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1).";
Proc. Natl. Acad. Sci. U.S.A. 100:12480-12485(2003).
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[14]
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FUNCTION, AND MUTAGENESIS OF ARG-785; LYS-788; ARG-797 AND SER-800.
DOI=10.1126/science.1083646; PubMed=12764195 [NCBI, ExPASy, EBI, Israel, Japan]
Prescott E.D.,
Julius D.;
"A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity.";
Science 300:1284-1288(2003).
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[15]
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INTERACTION WITH CSK.
DOI=10.1152/ajpcell.00113.2004; PubMed=15084474 [NCBI, ExPASy, EBI, Israel, Japan]
Jin X.,
Morsy N.,
Winston J.,
Pasricha P.J.,
Garrett K.,
Akbarali H.I.;
"Modulation of TRPV1 by nonreceptor tyrosine kinase, c-Src kinase.";
Am. J. Physiol. 287:C558-C563(2004).
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[16]
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MUTAGENESIS OF ARG-114; ARG-115 AND GLU-761.
DOI=10.1074/jbc.M207103200; PubMed=12228246 [NCBI, ExPASy, EBI, Israel, Japan]
Jung J.,
Lee S.Y.,
Hwang S.W.,
Cho H.,
Shin J.,
Kang Y.S.,
Kim S.,
Oh U.;
"Agonist recognition sites in the cytosolic tails of vanilloid receptor 1.";
J. Biol. Chem. 277:44448-44454(2002).
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[17]
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FUNCTION, PHOSPHORYLATION AT SER-502 AND THR-704, AND MUTAGENESIS OF SER-502 AND THR-704.
DOI=10.1074/jbc.M311448200; PubMed=14630912 [NCBI, ExPASy, EBI, Israel, Japan]
Jung J.,
Shin J.S.,
Lee S.-Y.,
Hwang S.W.,
Koo J.,
Cho H.,
Oh U.;
"Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding.";
J. Biol. Chem. 279:7048-7054(2004).
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[18]
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MUTAGENESIS OF TYR-511; MET-547 AND THR-550.
DOI=10.1074/jbc.M312577200; PubMed=14996838 [NCBI, ExPASy, EBI, Israel, Japan]
Gavva N.R.,
Klionsky L.,
Qu Y.,
Shi L.,
Tamir R.,
Edenson S.,
Zhang T.J.,
Viswanadhan V.N.,
Toth A.,
Pearce L.V.,
Vanderah T.W.,
Porreca F.,
Blumberg P.M.,
Lile J.,
Sun Y.,
Wild K.,
Louis J.C.,
Treanor J.J.;
"Molecular determinants of vanilloid sensitivity in TRPV1.";
J. Biol. Chem. 279:20283-20295(2004).
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[19]
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FUNCTION.
DOI=10.1074/jbc.M402966200; PubMed=15173182 [NCBI, ExPASy, EBI, Israel, Japan]
Hellwig N.,
Plant T.D.,
Janson W.,
Schafer M.,
Schultz G.,
Schaefer M.;
"TRPV1 acts as proton channel to induce acidification in nociceptive neurons.";
J. Biol. Chem. 279:34553-34561(2004).
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[20]
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INTERACTION WITH PRKCM, PHOSPHORYLATION AT SER-116, AND MUTAGENESIS OF SER-116.
DOI=10.1074/jbc.M410331200; PubMed=15471852 [NCBI, ExPASy, EBI, Israel, Japan]
Wang Y.,
Kedei N.,
Wang M.,
Wang Q.J.,
Huppler A.R.,
Toth A.,
Tran R.,
Blumberg P.M.;
"Interaction between protein kinase Cmu and the vanilloid receptor type 1.";
J. Biol. Chem. 279:53674-53682(2004).
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[21]
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SUBUNIT.
DOI=10.1523/JNEUROSCI.0202-04.2004; PubMed=15190102 [NCBI, ExPASy, EBI, Israel, Japan]
Garcia-Sanz N.,
Fernandez-Carvajal A.,
Morenilla-Palao C.,
Planells-Cases R.,
Fajardo-Sanchez E.,
Fernandez-Ballester G.,
Ferrer-Montiel A.;
"Identification of a tetramerization domain in the C-terminus of the vanilloid receptor.";
J. Neurosci. 24:5307-5314(2004).
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[22]
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X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 101-364, ATP-BINDING, AND DOMAINS ANKYRIN REPEATS.
DOI=10.1016/j.neuron.2007.05.027; PubMed=17582331 [NCBI, ExPASy, EBI, Israel, Japan]
Lishko P.V.,
Procko E.,
Jin X.,
Phelps C.B.,
Gaudet R.;
"The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity.";
Neuron 54:905-918(2007).
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