[1]
|
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Hybridoma;
DOI=10.1074/jbc.272.40.25190; PubMed=9312132 [NCBI, ExPASy, EBI, Israel, Japan]
Wong B.R.,
Rho J.,
Arron J.,
Robinson E.,
Orlinick J.,
Chao M.,
Kalachikov S.,
Cayani E.,
Bartlett F.S. III,
Frankel W.N.,
Lee S.Y.,
Choi Y.;
"TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells.";
J. Biol. Chem. 272:25190-25194(1997).
|
[2]
|
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Thymic lymphoma;
DOI=10.1038/36593; PubMed=9367155 [NCBI, ExPASy, EBI, Israel, Japan]
Anderson D.M.,
Maraskovsky E.,
Billingsley W.L.,
Dougall W.C.,
Tometsko M.E.,
Roux E.R.,
Teepe M.C.,
DuBose R.F.,
Cosman D.,
Galibert L.;
"A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.";
Nature 390:175-179(1997).
|
[3]
|
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Bone marrow;
DOI=10.1016/S0092-8674(00)81569-X; PubMed=9568710 [NCBI, ExPASy, EBI, Israel, Japan]
Lacey D.L.,
Timms E.,
Tan H.-L.,
Kelley M.J.,
Dunstan C.R.,
Burgess T.,
Elliott R.,
Colombero A.,
Elliott G.,
Scully S.,
Hsu H.,
Sullivan J.,
Hawkins N.,
Davy E.,
Capparelli C.,
Eli A.,
Qian Y.-X.,
Kaufman S.,
Sarosi I., ![]()
Shalhoub V.,
Senaldi G.,
Guo J.,
Delaney J.,
Boyle W.J.;
"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.";
Cell 93:165-176(1998).
|
[4]
|
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Bone marrow stroma;
DOI=10.1073/pnas.95.7.3597; PubMed=9520411 [NCBI, ExPASy, EBI, Israel, Japan]
Yasuda H.,
Shima N.,
Nakagawa N.,
Yamaguchi K.,
Kinosaki M.,
Mochizuki S.,
Tomoyasu A.,
Yano K.,
Goto M.,
Murakami A.,
Tsuda E.,
Morinaga T.,
Higashio K.,
Udagawa N.,
Takahashi N.,
Suda T.;
"Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL.";
Proc. Natl. Acad. Sci. U.S.A. 95:3597-3602(1998).
|
[5]
|
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
STRAIN=129;
DOI=10.1016/S0378-1119(99)00025-6; PubMed=10196481 [NCBI, ExPASy, EBI, Israel, Japan]
Kodaira K.,
Kodaira K.,
Mizuno A.,
Yasuda H.,
Shima N.,
Murakami A.,
Ueda M.,
Higashio K.;
"Cloning and characterization of the gene encoding mouse osteoclast differentiation factor.";
Gene 230:121-127(1999).
|
[6]
|
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
DOI=10.1210/en.142.4.1419; PubMed=11250921 [NCBI, ExPASy, EBI, Israel, Japan]
Ikeda T.,
Kasai M.,
Utsuyama M.,
Hirokawa K.;
"Determination of three isoforms of the receptor activator of nuclear factor-kappaB ligand and their differential expression in bone and thymus.";
Endocrinology 142:1419-1426(2001).
|
[7]
|
PROTEIN SEQUENCE OF 139-147, PROTEOLYTIC PROCESSING, AND GLYCOSYLATION.
DOI=10.1074/jbc.274.19.13613; PubMed=10224132 [NCBI, ExPASy, EBI, Israel, Japan]
Lum L.,
Wong B.R.,
Josien R.,
Becherer J.D.,
Erdjument-Bromage H.,
Schloendorff J.,
Tempst P.,
Choi Y.,
Blobel C.P.;
"Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival.";
J. Biol. Chem. 274:13613-13618(1999).
|
[8]
|
X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 158-316.
PubMed=11581298 [NCBI, ExPASy, EBI, Israel, Japan]
Lam J.,
Nelson C.A.,
Ross F.P.,
Teitelbaum S.L.,
Fremont D.H.;
"Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity.";
J. Clin. Invest. 108:971-979(2001).
|
[9]
|
X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 137-316.
DOI=10.1074/jbc.M106525200; PubMed=11733492 [NCBI, ExPASy, EBI, Israel, Japan]
Ito S.,
Wakabayashi K.,
Ubukata O.,
Hayashi S.,
Okada F.,
Hata T.;
"Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution.";
J. Biol. Chem. 277:6631-6636(2002).
|
|
- FUNCTION: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
- SUBUNIT: Homotrimer.
- SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type II membrane protein.
- SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type II membrane protein.
- SUBCELLULAR LOCATION: Isoform 3: Cytoplasm.
- SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 11, soluble form: Secreted.
- ALTERNATIVE PRODUCTS:
3 named isoforms [FASTA] produced by alternative splicing.
|
| Name | 2 |
| Isoform ID | O35235-2 |
| Features which should be applied to build the isoform sequence: VSP_006449. |
|
|
| Name | 3 |
| Isoform ID | O35235-3 |
| Features which should be applied to build the isoform sequence: VSP_006448. |
|
|
- TISSUE SPECIFICITY: Highly expressed in thymus and lymph nodes, but not in non-lymphoid tissues and is abundantly expressed in T-cells but not in B-cells. A high level expression is also seen in the trabecular bone and lung.
- PTM: N-glycosylated.
- PTM: The soluble form of isoform 1 derives from the membrane form by proteolytic processing. The cleavage may be catalyzed by ADAM17. A further shorter soluble form was observed.
- DISEASE: Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.
- SIMILARITY: Belongs to the tumor necrosis factor family.
|
ExPASy Home page
SIB Switzerland
